Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015586987> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2015586987 endingPage "44" @default.
- W2015586987 startingPage "42" @default.
- W2015586987 abstract "Paroxysmal nocturnal haemoglobinuria (PNH) is defined as a somatic mutation of a clonal population of stem cells. Consequently, when aplastic anaemia (AA) occurs in patients with a history of PNH, allogeneic bone marrow transplantation is considered as the only effective treatment. The impact of immunosuppressive therapy has not been reported in this situation. We present observations of three PNH patients who developed AA and were effectively treated with cyclosporin A (CSA). Because of lack of improvement with other treatments, CSA alone was given at a dose of 5-10mg/kg/d. Complete response (CR) was obtained in two patients after 6 and 24 months respectively. A partial response (PR) was observed in the third patient after 12 months. Transient elevated LDH and haemosiderinuria persisted in all cases. DAF and MIRL deficiency were still documented in the two patients in CR. Two patients (one CR, one PR) ceased CSA therapy after 12 months and relapsed within 3-6 months. CSA was reinitiated and led to platelet recovery in one patient after 6 months. The persistence of the abnormal PNH clone is coherent with the hypothesis that CSA does not act directly on the PNH clone but probably acts through regulation of the inhibitory effects of immunocompetent cells on haemopoiesis. These observations suggest that patients suffering from severe AA complicated PNH should not be excluded from immunosuppressive therapy." @default.
- W2015586987 created "2016-06-24" @default.
- W2015586987 creator A5008488155 @default.
- W2015586987 creator A5043613589 @default.
- W2015586987 creator A5045539102 @default.
- W2015586987 creator A5053724616 @default.
- W2015586987 creator A5067988180 @default.
- W2015586987 creator A5071922212 @default.
- W2015586987 creator A5077863801 @default.
- W2015586987 creator A5091498423 @default.
- W2015586987 date "1996-04-01" @default.
- W2015586987 modified "2023-10-02" @default.
- W2015586987 title "Correction of aplastic anaemia complicating paroxysmal nocturnal haemoglobinuria: absence of eradication of the PNH clone and dependence of response on cyclosporin A administration" @default.
- W2015586987 doi "https://doi.org/10.1046/j.1365-2141.1996.453993.x" @default.
- W2015586987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8611473" @default.
- W2015586987 hasPublicationYear "1996" @default.
- W2015586987 type Work @default.
- W2015586987 sameAs 2015586987 @default.
- W2015586987 citedByCount "25" @default.
- W2015586987 countsByYear W20155869872012 @default.
- W2015586987 countsByYear W20155869872013 @default.
- W2015586987 countsByYear W20155869872014 @default.
- W2015586987 countsByYear W20155869872016 @default.
- W2015586987 countsByYear W20155869872017 @default.
- W2015586987 countsByYear W20155869872021 @default.
- W2015586987 crossrefType "journal-article" @default.
- W2015586987 hasAuthorship W2015586987A5008488155 @default.
- W2015586987 hasAuthorship W2015586987A5043613589 @default.
- W2015586987 hasAuthorship W2015586987A5045539102 @default.
- W2015586987 hasAuthorship W2015586987A5053724616 @default.
- W2015586987 hasAuthorship W2015586987A5067988180 @default.
- W2015586987 hasAuthorship W2015586987A5071922212 @default.
- W2015586987 hasAuthorship W2015586987A5077863801 @default.
- W2015586987 hasAuthorship W2015586987A5091498423 @default.
- W2015586987 hasConcept C109159458 @default.
- W2015586987 hasConcept C126322002 @default.
- W2015586987 hasConcept C203014093 @default.
- W2015586987 hasConcept C2780007613 @default.
- W2015586987 hasConcept C2780525284 @default.
- W2015586987 hasConcept C2781440808 @default.
- W2015586987 hasConcept C28328180 @default.
- W2015586987 hasConcept C2908647359 @default.
- W2015586987 hasConcept C54355233 @default.
- W2015586987 hasConcept C552990157 @default.
- W2015586987 hasConcept C71924100 @default.
- W2015586987 hasConcept C81089528 @default.
- W2015586987 hasConcept C86803240 @default.
- W2015586987 hasConcept C90924648 @default.
- W2015586987 hasConcept C99454951 @default.
- W2015586987 hasConceptScore W2015586987C109159458 @default.
- W2015586987 hasConceptScore W2015586987C126322002 @default.
- W2015586987 hasConceptScore W2015586987C203014093 @default.
- W2015586987 hasConceptScore W2015586987C2780007613 @default.
- W2015586987 hasConceptScore W2015586987C2780525284 @default.
- W2015586987 hasConceptScore W2015586987C2781440808 @default.
- W2015586987 hasConceptScore W2015586987C28328180 @default.
- W2015586987 hasConceptScore W2015586987C2908647359 @default.
- W2015586987 hasConceptScore W2015586987C54355233 @default.
- W2015586987 hasConceptScore W2015586987C552990157 @default.
- W2015586987 hasConceptScore W2015586987C71924100 @default.
- W2015586987 hasConceptScore W2015586987C81089528 @default.
- W2015586987 hasConceptScore W2015586987C86803240 @default.
- W2015586987 hasConceptScore W2015586987C90924648 @default.
- W2015586987 hasConceptScore W2015586987C99454951 @default.
- W2015586987 hasIssue "1" @default.
- W2015586987 hasLocation W20155869871 @default.
- W2015586987 hasLocation W20155869872 @default.
- W2015586987 hasOpenAccess W2015586987 @default.
- W2015586987 hasPrimaryLocation W20155869871 @default.
- W2015586987 hasRelatedWork W164931435 @default.
- W2015586987 hasRelatedWork W19206636 @default.
- W2015586987 hasRelatedWork W1978598034 @default.
- W2015586987 hasRelatedWork W1983264920 @default.
- W2015586987 hasRelatedWork W2067301395 @default.
- W2015586987 hasRelatedWork W2253242983 @default.
- W2015586987 hasRelatedWork W2396323476 @default.
- W2015586987 hasRelatedWork W2469075738 @default.
- W2015586987 hasRelatedWork W3103959747 @default.
- W2015586987 hasRelatedWork W67301984 @default.
- W2015586987 hasVolume "93" @default.
- W2015586987 isParatext "false" @default.
- W2015586987 isRetracted "false" @default.
- W2015586987 magId "2015586987" @default.
- W2015586987 workType "article" @default.