FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015588350> ?p ?o ?g. }

• W2015588350 endingPage "72" @default.
• W2015588350 startingPage "68" @default.
• W2015588350 abstract "Background Heparanase activity plays a decisive role in biological processes associated with remodeling of the extracellular matrix (e.g., cancer metastasis, angiogenesis, and inflammation). Heparanase gene overexpression has been associated with advanced stage and poor survival in several cancers. We investigated the potential association between single nucleotide polymorphisms (SNPs) of the HPSE-1 gene, tumor susceptibility, clinicopathological parameters, and survival with gastric cancer among the Han population in northern China. Methods In this case–control study, there were 155 patients with gastric cancer and 204 healthy controls. The genotyping was performed using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) assay. Chi-square test was performed to exam differences of genotypes or alleles frequency between samples. The effect of various variables on outcome was investigated by multivariate analysis using the Cox proportional hazards model. Results We identified four polymorphisms in the HPSE-1 gene. Polymorphisms in introns 2 and 3, exon8, and exon13 occurred at a minor allele frequency of ≥10%. There was an increase in frequency of individuals with a genotype that carried the intron3 (A), exon8 (A), exon13 (G) haplotype (AAG) in patients with gastric cancer compared with healthy individuals (P = 0.0001; OR = 7.467; 95% CI: 2.274–24.509). SNP rs11099592 variant genotypes AG/AA were associated with a Borrmann type classification (P = 0.015; OR = 0.182; 95% CI: 0.049–0.668) and invasion depth (P = 0.020; OR = 0.341; 95% CI: 0.134–0.866), whereas SNP rs4328905 AG genotype was correlated to Lauren diffuse grade (P = 0.027; OR = 0.419; 95% CI 0.191–0.917). SNP rs6856901 variant genotypes GC/CC were associated with a better tumor-related survival (P = 0.028; OR = 0.504; 95% CI: 0.273–0.930) compared with GG genotype. Conclusions HPSE-1 polymorphisms may contribute to gastric tumor characteristics. SNP rs6856901 may be helpful in identifying clinical outcome of patients with gastric cancer. J. Surg. Oncol. J. Surg. Oncol. 2010;102:68–72. © 2010 Wiley-Liss, Inc." @default.
• W2015588350 created "2016-06-24" @default.
• W2015588350 creator A5021959959 @default.
• W2015588350 creator A5024546037 @default.
• W2015588350 creator A5034711230 @default.
• W2015588350 creator A5036590151 @default.
• W2015588350 creator A5049942775 @default.
• W2015588350 creator A5056904374 @default.
• W2015588350 creator A5083076234 @default.
• W2015588350 creator A5087376787 @default.
• W2015588350 date "2010-04-28" @default.
• W2015588350 modified "2023-10-18" @default.
• W2015588350 title "Association of heparanase gene (HPSE-1) single nucleotide polymorphisms with gastric cancer" @default.
• W2015588350 cites W1491748226 @default.
• W2015588350 cites W1999575197 @default.
• W2015588350 cites W2003727136 @default.
• W2015588350 cites W2009294883 @default.
• W2015588350 cites W2009962397 @default.
• W2015588350 cites W2011229547 @default.
• W2015588350 cites W2012339228 @default.
• W2015588350 cites W2025369063 @default.
• W2015588350 cites W2027590573 @default.
• W2015588350 cites W2030447006 @default.
• W2015588350 cites W2058401000 @default.
• W2015588350 cites W2069783532 @default.
• W2015588350 cites W2079269450 @default.
• W2015588350 cites W2100864793 @default.
• W2015588350 cites W2100959766 @default.
• W2015588350 cites W2107646761 @default.
• W2015588350 cites W2115914369 @default.
• W2015588350 cites W2126532720 @default.
• W2015588350 cites W2167914935 @default.
• W2015588350 doi "https://doi.org/10.1002/jso.21584" @default.
• W2015588350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20578081" @default.
• W2015588350 hasPublicationYear "2010" @default.
• W2015588350 type Work @default.
• W2015588350 sameAs 2015588350 @default.
• W2015588350 citedByCount "15" @default.
• W2015588350 countsByYear W20155883502012 @default.
• W2015588350 countsByYear W20155883502013 @default.
• W2015588350 countsByYear W20155883502016 @default.
• W2015588350 countsByYear W20155883502017 @default.
• W2015588350 countsByYear W20155883502018 @default.
• W2015588350 countsByYear W20155883502019 @default.
• W2015588350 countsByYear W20155883502020 @default.
• W2015588350 countsByYear W20155883502021 @default.
• W2015588350 crossrefType "journal-article" @default.
• W2015588350 hasAuthorship W2015588350A5021959959 @default.
• W2015588350 hasAuthorship W2015588350A5024546037 @default.
• W2015588350 hasAuthorship W2015588350A5034711230 @default.
• W2015588350 hasAuthorship W2015588350A5036590151 @default.
• W2015588350 hasAuthorship W2015588350A5049942775 @default.
• W2015588350 hasAuthorship W2015588350A5056904374 @default.
• W2015588350 hasAuthorship W2015588350A5083076234 @default.
• W2015588350 hasAuthorship W2015588350A5087376787 @default.
• W2015588350 hasConcept C104317684 @default.
• W2015588350 hasConcept C121608353 @default.
• W2015588350 hasConcept C126322002 @default.
• W2015588350 hasConcept C135763542 @default.
• W2015588350 hasConcept C139275648 @default.
• W2015588350 hasConcept C143998085 @default.
• W2015588350 hasConcept C153209595 @default.
• W2015588350 hasConcept C157410074 @default.
• W2015588350 hasConcept C180754005 @default.
• W2015588350 hasConcept C197754878 @default.
• W2015588350 hasConcept C2777478136 @default.
• W2015588350 hasConcept C2779013556 @default.
• W2015588350 hasConcept C2908647359 @default.
• W2015588350 hasConcept C31467283 @default.
• W2015588350 hasConcept C37463918 @default.
• W2015588350 hasConcept C54355233 @default.
• W2015588350 hasConcept C71924100 @default.
• W2015588350 hasConcept C86803240 @default.
• W2015588350 hasConcept C90924648 @default.
• W2015588350 hasConcept C99454951 @default.
• W2015588350 hasConceptScore W2015588350C104317684 @default.
• W2015588350 hasConceptScore W2015588350C121608353 @default.
• W2015588350 hasConceptScore W2015588350C126322002 @default.
• W2015588350 hasConceptScore W2015588350C135763542 @default.
• W2015588350 hasConceptScore W2015588350C139275648 @default.
• W2015588350 hasConceptScore W2015588350C143998085 @default.
• W2015588350 hasConceptScore W2015588350C153209595 @default.
• W2015588350 hasConceptScore W2015588350C157410074 @default.
• W2015588350 hasConceptScore W2015588350C180754005 @default.
• W2015588350 hasConceptScore W2015588350C197754878 @default.
• W2015588350 hasConceptScore W2015588350C2777478136 @default.
• W2015588350 hasConceptScore W2015588350C2779013556 @default.
• W2015588350 hasConceptScore W2015588350C2908647359 @default.
• W2015588350 hasConceptScore W2015588350C31467283 @default.
• W2015588350 hasConceptScore W2015588350C37463918 @default.
• W2015588350 hasConceptScore W2015588350C54355233 @default.
• W2015588350 hasConceptScore W2015588350C71924100 @default.
• W2015588350 hasConceptScore W2015588350C86803240 @default.
• W2015588350 hasConceptScore W2015588350C90924648 @default.
• W2015588350 hasConceptScore W2015588350C99454951 @default.
• W2015588350 hasIssue "1" @default.
• W2015588350 hasLocation W20155883501 @default.
• W2015588350 hasLocation W20155883502 @default.

• next