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- W2015590149 abstract "A cross-over experiment involves the application of sequences of treatments to several subjects over a number of time periods. It is thought that the observation made on each subject at the end of a time period may depend on the direct effect of the treatment applied in the current period, and the carry-over effects of the treatments applied in one or more previous periods. Various models have been proposed to explain the nature of the carry-over effects. An experimental design that is optimal under one model may not be optimal if a different model is the appropriate one. In this paper an algorithm is described to construct efficient cross-over designs for a range of models that involve the direct effects of the treatments and various functions of their carry-over effects. The effectiveness and flexibility of the algorithm are demonstrated by assessing its performance against numerous designs and models given in the literature." @default.
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- W2015590149 date "2004-08-12" @default.
- W2015590149 modified "2023-10-08" @default.
- W2015590149 title "CrossOver: an algorithm for the construction of efficient cross-over designs" @default.
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- W2015590149 doi "https://doi.org/10.1002/sim.1860" @default.
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