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- W2015591061 abstract "A model of colon peritoneal carcinomatosis was developed by injecting 5 × 107 viable tumor cells intraperitoneally into Fisher 344 rats. All 40 control rats developed bulky abdominal tumor with ascites and died of peritoneal carcinomatosis and bowel obstruction (median survival 5 weeks). One day after tumor implantation, treatment group rats received a single intraperitoneal injection of single agent or combination chemotherapy. The most active intraperitoneal single agents were 5-fluorouracil, cisplatin, and etoposide. The most active combination was 5-fluorouracil and cisplatin. Combination chemotherapy produced a significant increase in median, 10-week, and 20-week survival (vs control and single agent). Six of 11 (55%) rats treated with intraperitoneal combination chemotherapy dying between 10–20 weeks died of lung metastasis with cure of intraperitoneal tumor. The increased ability of intraperitoneal combination chemotherapy to cure intraperitoneal disease was offset by the development of lung metastasis." @default.
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- W2015591061 date "1991-02-01" @default.
- W2015591061 modified "2023-09-27" @default.
- W2015591061 title "Development of lung metastases after curative intraperitoneal chemotherapy in a rat colon cancer model" @default.
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- W2015591061 doi "https://doi.org/10.1016/0022-4804(91)90245-h" @default.
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