FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015591431> ?p ?o ?g. }

• W2015591431 endingPage "2093" @default.
• W2015591431 startingPage "2085" @default.
• W2015591431 abstract "Context: We describe the clinical investigation of the first generation aldosterone synthase inhibitor, LCI699, in patients with essential, uncontrolled, resistant, or secondary hypertension. LCI699 competitively reduced blood pressure at lower doses yet counterintuitive effects were observed at higher doses. Objective and method: An extensive endocrine biomarker analysis was performed to better understand the pharmacological mechanism of the drug. Results: The interference of LCI699 in the renin–angiotensin–aldosterone system occurred with limited target selectivity, as a dose-dependent compensatory stimulation of the hypothalamic-pituitary-adrenal feedback axis was discovered. Thus, LCI699 affected two endocrine feedback loops that converged at a single point, inhibiting the 11β-hydroxylase reaction in the adrenal gland, leading to supraphysiological levels of 11-deoxycortiscosterone. The accumulation of this potent mineralocorticoid may explain the blunted blood pressure response to LCI699. Conclusion: Future aldosterone synthase inhibitors may improve their target selectivity by sparing the 11β-hydroxylase reaction and preferentially inhibiting one of the two other enzymatic reactions mediated by aldosterone synthase." @default.
• W2015591431 created "2016-06-24" @default.
• W2015591431 creator A5019500673 @default.
• W2015591431 creator A5036167932 @default.
• W2015591431 creator A5076442267 @default.
• W2015591431 date "2013-10-01" @default.
• W2015591431 modified "2023-10-17" @default.
• W2015591431 title "Aldosterone synthase inhibition for the treatment of hypertension and the derived mechanistic requirements for a new therapeutic strategy" @default.
• W2015591431 cites W1521917359 @default.
• W2015591431 cites W1965251408 @default.
• W2015591431 cites W2011925462 @default.
• W2015591431 cites W2014029753 @default.
• W2015591431 cites W2024688814 @default.
• W2015591431 cites W2067481123 @default.
• W2015591431 cites W2076347631 @default.
• W2015591431 cites W2085448623 @default.
• W2015591431 cites W2108958077 @default.
• W2015591431 cites W2126204857 @default.
• W2015591431 cites W2145807241 @default.
• W2015591431 cites W2147573461 @default.
• W2015591431 cites W2148589377 @default.
• W2015591431 cites W2156597728 @default.
• W2015591431 cites W2163118201 @default.
• W2015591431 cites W2164705414 @default.
• W2015591431 cites W2323458614 @default.
• W2015591431 cites W2342067247 @default.
• W2015591431 cites W2950491028 @default.
• W2015591431 doi "https://doi.org/10.1097/hjh.0b013e328363570c" @default.
• W2015591431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3771574" @default.
• W2015591431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24107737" @default.
• W2015591431 hasPublicationYear "2013" @default.
• W2015591431 type Work @default.
• W2015591431 sameAs 2015591431 @default.
• W2015591431 citedByCount "30" @default.
• W2015591431 countsByYear W20155914312014 @default.
• W2015591431 countsByYear W20155914312015 @default.
• W2015591431 countsByYear W20155914312016 @default.
• W2015591431 countsByYear W20155914312017 @default.
• W2015591431 countsByYear W20155914312018 @default.
• W2015591431 countsByYear W20155914312019 @default.
• W2015591431 countsByYear W20155914312020 @default.
• W2015591431 countsByYear W20155914312021 @default.
• W2015591431 countsByYear W20155914312022 @default.
• W2015591431 countsByYear W20155914312023 @default.
• W2015591431 crossrefType "journal-article" @default.
• W2015591431 hasAuthorship W2015591431A5019500673 @default.
• W2015591431 hasAuthorship W2015591431A5036167932 @default.
• W2015591431 hasAuthorship W2015591431A5076442267 @default.
• W2015591431 hasBestOaLocation W20155914311 @default.
• W2015591431 hasConcept C126322002 @default.
• W2015591431 hasConcept C134018914 @default.
• W2015591431 hasConcept C151730666 @default.
• W2015591431 hasConcept C198710026 @default.
• W2015591431 hasConcept C24998067 @default.
• W2015591431 hasConcept C2776069600 @default.
• W2015591431 hasConcept C2778525890 @default.
• W2015591431 hasConcept C2779343474 @default.
• W2015591431 hasConcept C2780249997 @default.
• W2015591431 hasConcept C2908929049 @default.
• W2015591431 hasConcept C46699223 @default.
• W2015591431 hasConcept C71315377 @default.
• W2015591431 hasConcept C71924100 @default.
• W2015591431 hasConcept C84393581 @default.
• W2015591431 hasConcept C86803240 @default.
• W2015591431 hasConcept C98274493 @default.
• W2015591431 hasConceptScore W2015591431C126322002 @default.
• W2015591431 hasConceptScore W2015591431C134018914 @default.
• W2015591431 hasConceptScore W2015591431C151730666 @default.
• W2015591431 hasConceptScore W2015591431C198710026 @default.
• W2015591431 hasConceptScore W2015591431C24998067 @default.
• W2015591431 hasConceptScore W2015591431C2776069600 @default.
• W2015591431 hasConceptScore W2015591431C2778525890 @default.
• W2015591431 hasConceptScore W2015591431C2779343474 @default.
• W2015591431 hasConceptScore W2015591431C2780249997 @default.
• W2015591431 hasConceptScore W2015591431C2908929049 @default.
• W2015591431 hasConceptScore W2015591431C46699223 @default.
• W2015591431 hasConceptScore W2015591431C71315377 @default.
• W2015591431 hasConceptScore W2015591431C71924100 @default.
• W2015591431 hasConceptScore W2015591431C84393581 @default.
• W2015591431 hasConceptScore W2015591431C86803240 @default.
• W2015591431 hasConceptScore W2015591431C98274493 @default.
• W2015591431 hasIssue "10" @default.
• W2015591431 hasLocation W20155914311 @default.
• W2015591431 hasLocation W20155914312 @default.
• W2015591431 hasLocation W20155914313 @default.
• W2015591431 hasLocation W20155914314 @default.
• W2015591431 hasLocation W20155914315 @default.
• W2015591431 hasOpenAccess W2015591431 @default.
• W2015591431 hasPrimaryLocation W20155914311 @default.
• W2015591431 hasRelatedWork W1567525892 @default.
• W2015591431 hasRelatedWork W1974641745 @default.
• W2015591431 hasRelatedWork W1992220075 @default.
• W2015591431 hasRelatedWork W2006202112 @default.
• W2015591431 hasRelatedWork W2024736606 @default.
• W2015591431 hasRelatedWork W2031245924 @default.
• W2015591431 hasRelatedWork W2033713032 @default.
• W2015591431 hasRelatedWork W2054593959 @default.
• W2015591431 hasRelatedWork W2151139437 @default.

• next