FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015595536> ?p ?o ?g. }

• W2015595536 endingPage "597" @default.
• W2015595536 startingPage "589" @default.
• W2015595536 abstract "To compare detection rates and evaluate the clinical relevance of cytokeratin-19 (CK-19) mRNA-positive cells in the peripheral blood (circulating tumour cells, CTCs) and bone marrow (disseminated tumour cells; DTCs) of patients with early breast cancer.Paired samples of peripheral blood and bone marrow were obtained from 165 patients with stage I-II breast cancer before the initiation of adjuvant chemotherapy. In 84 patients, paired blood and bone marrow samples were also available after chemotherapy. The detection of CK-19 mRNA-positive CTCs and DTCs was assessed by real-time PCR.CK-19 mRNA-positive CTCs and DTCs were detected in 55.2 and 57.6% of patients before chemotherapy, respectively. After chemotherapy, CTCs and DTCs were identified in 44 (52.4%) and 43 (51.2%) of the 84 patients, respectively. There was a 93.9% (McNemar; P=0.344) and 72.6% (McNemar; P=0.999) concordance between blood and bone marrow samples before and after chemotherapy, respectively. The detection of CK-19 mRNA-positive CTCs or DTCs before chemotherapy was associated with decreased overall survival (P=0.024 and P=0.015, respectively). In addition, their simultaneous detection was also associated with an increased incidence of disease-related death and decreased overall survival (P=0.016).The detection of CK-19 mRNA-positive CTCs using reverse transcription-PCR (RT-PCR) both before and after chemotherapy is correlated with the detection of CK-19 mRNA-positive DTCs in patients with early-stage breast cancer. The determination of the CTC status by RT-PCR conveys clinically relevant information that is not inferior to DTC status and, owing to the ease of sampling, warrants further evaluation as a tool for monitoring minimal residual disease." @default.
• W2015595536 created "2016-06-24" @default.
• W2015595536 creator A5020695093 @default.
• W2015595536 creator A5020917862 @default.
• W2015595536 creator A5021554009 @default.
• W2015595536 creator A5035832029 @default.
• W2015595536 creator A5065290885 @default.
• W2015595536 creator A5073573532 @default.
• W2015595536 creator A5074069899 @default.
• W2015595536 creator A5076146802 @default.
• W2015595536 creator A5084377238 @default.
• W2015595536 creator A5087365707 @default.
• W2015595536 date "2009-07-21" @default.
• W2015595536 modified "2023-10-10" @default.
• W2015595536 title "Detection of cytokeratin-19 mRNA-positive cells in the peripheral blood and bone marrow of patients with operable breast cancer" @default.
• W2015595536 cites W125031896 @default.
• W2015595536 cites W1262485082 @default.
• W2015595536 cites W1944919483 @default.
• W2015595536 cites W1961026612 @default.
• W2015595536 cites W1980143004 @default.
• W2015595536 cites W1980299983 @default.
• W2015595536 cites W1987509621 @default.
• W2015595536 cites W1990877651 @default.
• W2015595536 cites W2030694699 @default.
• W2015595536 cites W2063429605 @default.
• W2015595536 cites W2077990988 @default.
• W2015595536 cites W2090424555 @default.
• W2015595536 cites W2096910745 @default.
• W2015595536 cites W2098915144 @default.
• W2015595536 cites W2102734247 @default.
• W2015595536 cites W2102949315 @default.
• W2015595536 cites W2111976640 @default.
• W2015595536 cites W2115971576 @default.
• W2015595536 cites W2117199645 @default.
• W2015595536 cites W2119480061 @default.
• W2015595536 cites W2120426806 @default.
• W2015595536 cites W2121672045 @default.
• W2015595536 cites W2122938591 @default.
• W2015595536 cites W2126735047 @default.
• W2015595536 cites W2140090725 @default.
• W2015595536 cites W2142946766 @default.
• W2015595536 cites W2145056062 @default.
• W2015595536 cites W2152835558 @default.
• W2015595536 cites W2156414461 @default.
• W2015595536 cites W2167238270 @default.
• W2015595536 cites W2168988726 @default.
• W2015595536 cites W2271721498 @default.
• W2015595536 cites W2321753125 @default.
• W2015595536 doi "https://doi.org/10.1038/sj.bjc.6605183" @default.
• W2015595536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2736820" @default.
• W2015595536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19623181" @default.
• W2015595536 hasPublicationYear "2009" @default.
• W2015595536 type Work @default.
• W2015595536 sameAs 2015595536 @default.
• W2015595536 citedByCount "94" @default.
• W2015595536 countsByYear W20155955362012 @default.
• W2015595536 countsByYear W20155955362013 @default.
• W2015595536 countsByYear W20155955362014 @default.
• W2015595536 countsByYear W20155955362015 @default.
• W2015595536 countsByYear W20155955362016 @default.
• W2015595536 countsByYear W20155955362017 @default.
• W2015595536 countsByYear W20155955362018 @default.
• W2015595536 countsByYear W20155955362019 @default.
• W2015595536 countsByYear W20155955362020 @default.
• W2015595536 countsByYear W20155955362021 @default.
• W2015595536 countsByYear W20155955362023 @default.
• W2015595536 crossrefType "journal-article" @default.
• W2015595536 hasAuthorship W2015595536A5020695093 @default.
• W2015595536 hasAuthorship W2015595536A5020917862 @default.
• W2015595536 hasAuthorship W2015595536A5021554009 @default.
• W2015595536 hasAuthorship W2015595536A5035832029 @default.
• W2015595536 hasAuthorship W2015595536A5065290885 @default.
• W2015595536 hasAuthorship W2015595536A5073573532 @default.
• W2015595536 hasAuthorship W2015595536A5074069899 @default.
• W2015595536 hasAuthorship W2015595536A5076146802 @default.
• W2015595536 hasAuthorship W2015595536A5084377238 @default.
• W2015595536 hasAuthorship W2015595536A5087365707 @default.
• W2015595536 hasBestOaLocation W20155955361 @default.
• W2015595536 hasConcept C121608353 @default.
• W2015595536 hasConcept C126322002 @default.
• W2015595536 hasConcept C142724271 @default.
• W2015595536 hasConcept C143998085 @default.
• W2015595536 hasConcept C204232928 @default.
• W2015595536 hasConcept C2776694085 @default.
• W2015595536 hasConcept C2778123414 @default.
• W2015595536 hasConcept C2779012181 @default.
• W2015595536 hasConcept C2779013556 @default.
• W2015595536 hasConcept C2780007613 @default.
• W2015595536 hasConcept C530470458 @default.
• W2015595536 hasConcept C61238886 @default.
• W2015595536 hasConcept C71924100 @default.
• W2015595536 hasConceptScore W2015595536C121608353 @default.
• W2015595536 hasConceptScore W2015595536C126322002 @default.
• W2015595536 hasConceptScore W2015595536C142724271 @default.
• W2015595536 hasConceptScore W2015595536C143998085 @default.
• W2015595536 hasConceptScore W2015595536C204232928 @default.
• W2015595536 hasConceptScore W2015595536C2776694085 @default.
• W2015595536 hasConceptScore W2015595536C2778123414 @default.

• next