FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015596391> ?p ?o ?g. }

• W2015596391 endingPage "99" @default.
• W2015596391 startingPage "91" @default.
• W2015596391 abstract "The assembly of N-linked glycoproteins in eukaryotic cells begins with the segregation of these molecules within the lumen of intracellular vesicles. Since the sugar nucleotides are cytoplasmic molecules, translocation of the sugar moiety across the membrane appears as a crucial event in the glycoprotein synthesis. This N-glycosylation process occurs in two different cytological sites: in the rough endoplasmic reticulum, the stepwise synthesis of a large lipid-linked oligosaccharide takes place, as well as its transfer to protein; then after trimming the immature glycoprotein is further elongated in the Golgi apparatus. In this paper, a brief review will be given of the present knowledge on the sugar donor transport across the membrane barrier to the glycosylation site. Based upon the transmembrane orientation of oligosaccharide lipid intermediates and on the localization of the glycosyltransferase active sites, the different processes required to translocate the sugar moieties during the preassembly of the dolichyl-pyrophosphate-oligosaccharides will be examined. Combining the different results, obtained in several laboratories, it is suggested that the Man5-GlcNAc2-lipid is synthesized on the cytoplasmic side directly from the sugar-nucleotides and then translocated to the lumenal face where the Glc3-Man9-GlcNAc2-lipid is completed using Man-P-Dol and Glc-P-Dol as transmembrane carriers of these sugars. Concerning the elongation process leading to assembly of the antennae of N-acetyllactosamine type oligosaccharides, specific carriers for sugar nucleotides have been described as Golgi markers. Several authors have characterized such carriers for UDP-Gal, GDP-Fuc, CMP-NeuAc, UDP-GlcNAc and UDP-Glc using microsomal vesicles and similar results have been obtained in our laboratory using plasma membrane permeabilized cells. This carrier-mediated process leads to the formation of an intralumenal pool whose biological significance will be discussed. The translocation process of sugar donors occurring in the rough endoplasmic reticulum via lipid intermediates as well as in the Golgi apparatus via specific carriers would represent a regulation step based on the availability of the substrates for the glycosylation." @default.
• W2015596391 created "2016-06-24" @default.
• W2015596391 creator A5006317440 @default.
• W2015596391 creator A5020250273 @default.
• W2015596391 creator A5027310195 @default.
• W2015596391 date "1987-02-01" @default.
• W2015596391 modified "2023-09-25" @default.
• W2015596391 title "Membrane transport of sugar donors to the glycosylation sites" @default.
• W2015596391 cites W1501428107 @default.
• W2015596391 cites W1508005690 @default.
• W2015596391 cites W1508760371 @default.
• W2015596391 cites W1512824894 @default.
• W2015596391 cites W1527929194 @default.
• W2015596391 cites W1542672873 @default.
• W2015596391 cites W1542775374 @default.
• W2015596391 cites W1573160214 @default.
• W2015596391 cites W1576620622 @default.
• W2015596391 cites W1590438213 @default.
• W2015596391 cites W1707184912 @default.
• W2015596391 cites W1901274515 @default.
• W2015596391 cites W1963001142 @default.
• W2015596391 cites W1970429487 @default.
• W2015596391 cites W1971338863 @default.
• W2015596391 cites W1973065848 @default.
• W2015596391 cites W2009441709 @default.
• W2015596391 cites W2027126337 @default.
• W2015596391 cites W2051450676 @default.
• W2015596391 cites W2052865514 @default.
• W2015596391 cites W2063048256 @default.
• W2015596391 cites W2067745914 @default.
• W2015596391 cites W2070647271 @default.
• W2015596391 cites W2077149765 @default.
• W2015596391 cites W2078868081 @default.
• W2015596391 cites W2084799821 @default.
• W2015596391 cites W2152708819 @default.
• W2015596391 cites W2161622051 @default.
• W2015596391 cites W2221053269 @default.
• W2015596391 cites W2441688177 @default.
• W2015596391 cites W6977459 @default.
• W2015596391 doi "https://doi.org/10.1016/0300-9084(87)90240-9" @default.
• W2015596391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3105606" @default.
• W2015596391 hasPublicationYear "1987" @default.
• W2015596391 type Work @default.
• W2015596391 sameAs 2015596391 @default.
• W2015596391 citedByCount "18" @default.
• W2015596391 crossrefType "journal-article" @default.
• W2015596391 hasAuthorship W2015596391A5006317440 @default.
• W2015596391 hasAuthorship W2015596391A5020250273 @default.
• W2015596391 hasAuthorship W2015596391A5027310195 @default.
• W2015596391 hasConcept C108625454 @default.
• W2015596391 hasConcept C119062480 @default.
• W2015596391 hasConcept C130316041 @default.
• W2015596391 hasConcept C158617107 @default.
• W2015596391 hasConcept C161019410 @default.
• W2015596391 hasConcept C170493617 @default.
• W2015596391 hasConcept C181199279 @default.
• W2015596391 hasConcept C185592680 @default.
• W2015596391 hasConcept C190062978 @default.
• W2015596391 hasConcept C206912223 @default.
• W2015596391 hasConcept C24530287 @default.
• W2015596391 hasConcept C26664279 @default.
• W2015596391 hasConcept C2777313579 @default.
• W2015596391 hasConcept C39944091 @default.
• W2015596391 hasConcept C41625074 @default.
• W2015596391 hasConcept C55493867 @default.
• W2015596391 hasConcept C6492254 @default.
• W2015596391 hasConcept C86803240 @default.
• W2015596391 hasConcept C95444343 @default.
• W2015596391 hasConceptScore W2015596391C108625454 @default.
• W2015596391 hasConceptScore W2015596391C119062480 @default.
• W2015596391 hasConceptScore W2015596391C130316041 @default.
• W2015596391 hasConceptScore W2015596391C158617107 @default.
• W2015596391 hasConceptScore W2015596391C161019410 @default.
• W2015596391 hasConceptScore W2015596391C170493617 @default.
• W2015596391 hasConceptScore W2015596391C181199279 @default.
• W2015596391 hasConceptScore W2015596391C185592680 @default.
• W2015596391 hasConceptScore W2015596391C190062978 @default.
• W2015596391 hasConceptScore W2015596391C206912223 @default.
• W2015596391 hasConceptScore W2015596391C24530287 @default.
• W2015596391 hasConceptScore W2015596391C26664279 @default.
• W2015596391 hasConceptScore W2015596391C2777313579 @default.
• W2015596391 hasConceptScore W2015596391C39944091 @default.
• W2015596391 hasConceptScore W2015596391C41625074 @default.
• W2015596391 hasConceptScore W2015596391C55493867 @default.
• W2015596391 hasConceptScore W2015596391C6492254 @default.
• W2015596391 hasConceptScore W2015596391C86803240 @default.
• W2015596391 hasConceptScore W2015596391C95444343 @default.
• W2015596391 hasIssue "2" @default.
• W2015596391 hasLocation W20155963911 @default.
• W2015596391 hasLocation W20155963912 @default.
• W2015596391 hasLocation W20155963913 @default.
• W2015596391 hasOpenAccess W2015596391 @default.
• W2015596391 hasPrimaryLocation W20155963911 @default.
• W2015596391 hasRelatedWork W110953117 @default.
• W2015596391 hasRelatedWork W1167578656 @default.
• W2015596391 hasRelatedWork W1517334531 @default.
• W2015596391 hasRelatedWork W1561669317 @default.
• W2015596391 hasRelatedWork W171301016 @default.

• next