FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015603774> ?p ?o ?g. }

• W2015603774 endingPage "894" @default.
• W2015603774 startingPage "888" @default.
• W2015603774 abstract "The liver is considered a tolerogenic organ that favors the induction of peripheral tolerance and protects other organs from the same donor from rejection. This has been exploited in combined auxiliary liver-kidney transplantation, where a renal graft is transplanted against a positive crossmatch under the protection of a liver transplanted from the same donor.To elucidate mechanisms behind the liver protective effect, we studied early transcriptional changes of inflammatory mediators in the grafts during combined auxiliary liver-kidney transplantation using microarrays and real-time polymerase chain reaction. The results were correlated to clinical data.Liver and kidney grafts both exhibited an upregulation of the leukocyte-recruiting chemokines CCL2, CCL3, and CCL4. Notably, liver grafts strongly upregulated CCL20, a dendritic cell, and T-cell recruiting chemokine. By comparing the gene expression in liver grafts with the clinical outcome, we found that 14 of 45 investigated inflammatory genes were expressed significantly higher in patients without early rejection when compared with those with early rejections. This included the above-mentioned chemokines and the T-cell-recruiting CX3CL1, NFKB1, and the tolerance-inducing gene indoleamine 2,3-dioxygenase.In this study, the protective role of the liver was associated with a proinflammatory reaction within this organ after ischemia-reperfusion. In particular, we found an increased expression of leukocyte-recruiting chemokines in patients without rejection, indicating a protective role of host inflammatory cells infiltrating the auxiliary liver graft in presensitized patients. Second, gene expression profiling of transplant biopsies shortly after reperfusion predicted the risk of early rejection in these patients." @default.
• W2015603774 created "2016-06-24" @default.
• W2015603774 creator A5022809040 @default.
• W2015603774 creator A5030712482 @default.
• W2015603774 creator A5034978139 @default.
• W2015603774 creator A5042130334 @default.
• W2015603774 creator A5048193083 @default.
• W2015603774 creator A5071217435 @default.
• W2015603774 creator A5079475105 @default.
• W2015603774 date "2011-04-27" @default.
• W2015603774 modified "2023-10-18" @default.
• W2015603774 title "Postischemic Inflammatory Response in an Auxiliary Liver Graft Predicts Renal Graft Outcome in Sensitized Patients" @default.
• W2015603774 cites W1557393597 @default.
• W2015603774 cites W1951483940 @default.
• W2015603774 cites W1992195114 @default.
• W2015603774 cites W1998105299 @default.
• W2015603774 cites W2001505801 @default.
• W2015603774 cites W2006549902 @default.
• W2015603774 cites W2010378562 @default.
• W2015603774 cites W2028653503 @default.
• W2015603774 cites W2030274424 @default.
• W2015603774 cites W2037555606 @default.
• W2015603774 cites W2041452979 @default.
• W2015603774 cites W2047719515 @default.
• W2015603774 cites W2048070434 @default.
• W2015603774 cites W2068763413 @default.
• W2015603774 cites W2072078248 @default.
• W2015603774 cites W2093204555 @default.
• W2015603774 cites W2122285073 @default.
• W2015603774 cites W2132864620 @default.
• W2015603774 cites W2144851189 @default.
• W2015603774 cites W2152857351 @default.
• W2015603774 cites W2158500407 @default.
• W2015603774 cites W4313333699 @default.
• W2015603774 doi "https://doi.org/10.1097/tp.0b013e3182100f19" @default.
• W2015603774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21494202" @default.
• W2015603774 hasPublicationYear "2011" @default.
• W2015603774 type Work @default.
• W2015603774 sameAs 2015603774 @default.
• W2015603774 citedByCount "20" @default.
• W2015603774 countsByYear W20156037742012 @default.
• W2015603774 countsByYear W20156037742013 @default.
• W2015603774 countsByYear W20156037742014 @default.
• W2015603774 countsByYear W20156037742015 @default.
• W2015603774 countsByYear W20156037742016 @default.
• W2015603774 countsByYear W20156037742017 @default.
• W2015603774 countsByYear W20156037742018 @default.
• W2015603774 countsByYear W20156037742019 @default.
• W2015603774 countsByYear W20156037742020 @default.
• W2015603774 countsByYear W20156037742022 @default.
• W2015603774 crossrefType "journal-article" @default.
• W2015603774 hasAuthorship W2015603774A5022809040 @default.
• W2015603774 hasAuthorship W2015603774A5030712482 @default.
• W2015603774 hasAuthorship W2015603774A5034978139 @default.
• W2015603774 hasAuthorship W2015603774A5042130334 @default.
• W2015603774 hasAuthorship W2015603774A5048193083 @default.
• W2015603774 hasAuthorship W2015603774A5071217435 @default.
• W2015603774 hasAuthorship W2015603774A5079475105 @default.
• W2015603774 hasConcept C101666144 @default.
• W2015603774 hasConcept C104317684 @default.
• W2015603774 hasConcept C110015553 @default.
• W2015603774 hasConcept C126322002 @default.
• W2015603774 hasConcept C127561419 @default.
• W2015603774 hasConcept C12823836 @default.
• W2015603774 hasConcept C13373296 @default.
• W2015603774 hasConcept C164027704 @default.
• W2015603774 hasConcept C203014093 @default.
• W2015603774 hasConcept C2776914184 @default.
• W2015603774 hasConcept C2779609443 @default.
• W2015603774 hasConcept C2780091579 @default.
• W2015603774 hasConcept C2911091166 @default.
• W2015603774 hasConcept C55493867 @default.
• W2015603774 hasConcept C71924100 @default.
• W2015603774 hasConcept C83360876 @default.
• W2015603774 hasConcept C86803240 @default.
• W2015603774 hasConceptScore W2015603774C101666144 @default.
• W2015603774 hasConceptScore W2015603774C104317684 @default.
• W2015603774 hasConceptScore W2015603774C110015553 @default.
• W2015603774 hasConceptScore W2015603774C126322002 @default.
• W2015603774 hasConceptScore W2015603774C127561419 @default.
• W2015603774 hasConceptScore W2015603774C12823836 @default.
• W2015603774 hasConceptScore W2015603774C13373296 @default.
• W2015603774 hasConceptScore W2015603774C164027704 @default.
• W2015603774 hasConceptScore W2015603774C203014093 @default.
• W2015603774 hasConceptScore W2015603774C2776914184 @default.
• W2015603774 hasConceptScore W2015603774C2779609443 @default.
• W2015603774 hasConceptScore W2015603774C2780091579 @default.
• W2015603774 hasConceptScore W2015603774C2911091166 @default.
• W2015603774 hasConceptScore W2015603774C55493867 @default.
• W2015603774 hasConceptScore W2015603774C71924100 @default.
• W2015603774 hasConceptScore W2015603774C83360876 @default.
• W2015603774 hasConceptScore W2015603774C86803240 @default.
• W2015603774 hasIssue "8" @default.
• W2015603774 hasLocation W20156037741 @default.
• W2015603774 hasLocation W20156037742 @default.
• W2015603774 hasOpenAccess W2015603774 @default.
• W2015603774 hasPrimaryLocation W20156037741 @default.
• W2015603774 hasRelatedWork W1979435024 @default.

• next