Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015606965> ?p ?o ?g. }
- W2015606965 endingPage "605" @default.
- W2015606965 startingPage "605" @default.
- W2015606965 abstract "The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of genomic integrity. Inherited mutations in these genes are associated with the development of cancer in multiple organs including the breast and ovary. Mutations of BRCA1/2 genes greatly increase lifetime risk to develop breast and ovarian cancer and these mutations are frequently observed in hereditary breast and ovarian cancers. In addition, misregulation and altered expressions of BRCA1/2 proteins potentiate sporadic forms of breast cancer. In particular, both genes contribute to DNA repair and transcriptional regulation in response to DNA damage. Thus, deficiencies of BRCA1/2 functions lead to the accumulation of genetic alterations and ultimately influence the development of cancer. Studies since identification of both BRCA1 and BRCA2 have provided strong evidences for their tumor suppressor activities specifically for breast and ovarian cancer and this article aims to review the current state of knowledge regarding the BRCAs and associated cancer risk." @default.
- W2015606965 created "2016-06-24" @default.
- W2015606965 creator A5050470588 @default.
- W2015606965 date "2014-01-01" @default.
- W2015606965 modified "2023-09-30" @default.
- W2015606965 title "The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers" @default.
- W2015606965 cites W123399785 @default.
- W2015606965 cites W1487538033 @default.
- W2015606965 cites W1518015545 @default.
- W2015606965 cites W1576826397 @default.
- W2015606965 cites W1605474609 @default.
- W2015606965 cites W1640093800 @default.
- W2015606965 cites W1898353313 @default.
- W2015606965 cites W1902704112 @default.
- W2015606965 cites W1961774825 @default.
- W2015606965 cites W1963605606 @default.
- W2015606965 cites W1964579258 @default.
- W2015606965 cites W1965012270 @default.
- W2015606965 cites W1966479600 @default.
- W2015606965 cites W1966947732 @default.
- W2015606965 cites W1969150779 @default.
- W2015606965 cites W1971322560 @default.
- W2015606965 cites W1971673692 @default.
- W2015606965 cites W1972103684 @default.
- W2015606965 cites W1972152765 @default.
- W2015606965 cites W1972710550 @default.
- W2015606965 cites W1973268287 @default.
- W2015606965 cites W1976385056 @default.
- W2015606965 cites W1976960697 @default.
- W2015606965 cites W1977558343 @default.
- W2015606965 cites W1979256255 @default.
- W2015606965 cites W1981864085 @default.
- W2015606965 cites W1986627314 @default.
- W2015606965 cites W1986671812 @default.
- W2015606965 cites W1986926802 @default.
- W2015606965 cites W1989841784 @default.
- W2015606965 cites W1992121629 @default.
- W2015606965 cites W1993797093 @default.
- W2015606965 cites W1997117872 @default.
- W2015606965 cites W1997487041 @default.
- W2015606965 cites W1998492363 @default.
- W2015606965 cites W1999002383 @default.
- W2015606965 cites W2000161680 @default.
- W2015606965 cites W2000437208 @default.
- W2015606965 cites W2000820980 @default.
- W2015606965 cites W2001537741 @default.
- W2015606965 cites W2002555966 @default.
- W2015606965 cites W2004351764 @default.
- W2015606965 cites W2005284058 @default.
- W2015606965 cites W2009007206 @default.
- W2015606965 cites W2010939704 @default.
- W2015606965 cites W2011658104 @default.
- W2015606965 cites W2011692660 @default.
- W2015606965 cites W2014140511 @default.
- W2015606965 cites W2014178540 @default.
- W2015606965 cites W2015918164 @default.
- W2015606965 cites W2016406151 @default.
- W2015606965 cites W2016760769 @default.
- W2015606965 cites W2017714068 @default.
- W2015606965 cites W2018625286 @default.
- W2015606965 cites W2019205168 @default.
- W2015606965 cites W2019727578 @default.
- W2015606965 cites W2022176772 @default.
- W2015606965 cites W2024131694 @default.
- W2015606965 cites W2024503639 @default.
- W2015606965 cites W2025370752 @default.
- W2015606965 cites W2028154024 @default.
- W2015606965 cites W2028498265 @default.
- W2015606965 cites W2032294980 @default.
- W2015606965 cites W2032298890 @default.
- W2015606965 cites W2032878080 @default.
- W2015606965 cites W2034317592 @default.
- W2015606965 cites W2034434851 @default.
- W2015606965 cites W2036245489 @default.
- W2015606965 cites W2036546668 @default.
- W2015606965 cites W2037191150 @default.
- W2015606965 cites W2037954444 @default.
- W2015606965 cites W2038275315 @default.
- W2015606965 cites W2039135884 @default.
- W2015606965 cites W2039211343 @default.
- W2015606965 cites W2042970469 @default.
- W2015606965 cites W2043739672 @default.
- W2015606965 cites W2044713924 @default.
- W2015606965 cites W2046598241 @default.
- W2015606965 cites W2047460928 @default.
- W2015606965 cites W2047985441 @default.
- W2015606965 cites W2048345378 @default.
- W2015606965 cites W2048619264 @default.
- W2015606965 cites W2048867718 @default.
- W2015606965 cites W2049572301 @default.
- W2015606965 cites W2049598883 @default.
- W2015606965 cites W2050061987 @default.
- W2015606965 cites W2051409228 @default.
- W2015606965 cites W2055250905 @default.
- W2015606965 cites W2057620850 @default.
- W2015606965 cites W2057626690 @default.
- W2015606965 cites W2057949133 @default.
- W2015606965 cites W2059000312 @default.