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• W2015612902 abstract "The HpxO enzyme from Klebsiella pneumoniae was recently proposed, on the basis of genetic studies, to catalyze the hydroxylation of uric acid to 5-hydroxyisourate as part of the purine catabolic pathway. Its primary sequence suggests that the HpxO catalytic activity depends on a flavin cofactor (FAD), contrasting with all previously studied urate oxidase enzymes, which have no cofactor requirement. Here we demonstrate biochemically that HpxO is an FAD-dependent urate oxidase. Our data are consistent with the proposal that HpxO-bound flavin hydroperoxide is the hydroxylating species. These results confirm the existence of a novel mechanistic paradigm in purine catabolism." @default.
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• W2015612902 date "2009-03-20" @default.
• W2015612902 modified "2023-09-28" @default.
• W2015612902 title "Biochemical Characterization of the HpxO Enzyme from <i>Klebsiella pneumoniae</i>, a Novel FAD-Dependent Urate Oxidase" @default.
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• W2015612902 doi "https://doi.org/10.1021/bi900160b" @default.
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