Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015614056> ?p ?o ?g. }
- W2015614056 endingPage "11293" @default.
- W2015614056 startingPage "11275" @default.
- W2015614056 abstract "Transplantation of mesenchymal stem cells (MSC) improves functional recovery in experimental models of spinal cord injury (SCI); however, the mechanisms underlying this effect are not completely understood. We investigated the effect of intrathecal implantation of human MSC on functional recovery, astrogliosis and levels of inflammatory cytokines in rats using balloon-induced spinal cord compression lesions. Transplanted cells did not survive at the lesion site of the spinal cord; however, functional recovery was enhanced in the MSC-treated group as was confirmed by the Basso, Beattie, and Bresnahan (BBB) and the flat beam test. Morphometric analysis showed a significantly higher amount of remaining white matter in the cranial part of the lesioned spinal cords. Immunohistochemical analysis of the lesions indicated the rearrangement of the glial scar in MSC-treated animals. Real-time PCR analysis revealed an increased expression of Irf5, Mrc1, Fgf2, Gap43 and Gfap. Transplantation of MSCs into a lesioned spinal cord reduced TNFα, IL-4, IL-1β, IL-2, IL-6 and IL-12 and increased the levels of MIP-1α and RANTES when compared to saline-treated controls. Intrathecal implantation of MSCs reduces the inflammatory reaction and apoptosis, improves functional recovery and modulates glial scar formation after SCI, regardless of cell survival. Therefore, repeated applications may prolong the beneficial effects induced by MSC application." @default.
- W2015614056 created "2016-06-24" @default.
- W2015614056 creator A5000968218 @default.
- W2015614056 creator A5004335610 @default.
- W2015614056 creator A5007470850 @default.
- W2015614056 creator A5025520471 @default.
- W2015614056 creator A5065203934 @default.
- W2015614056 creator A5067795929 @default.
- W2015614056 creator A5070295349 @default.
- W2015614056 creator A5081252742 @default.
- W2015614056 creator A5081690507 @default.
- W2015614056 creator A5084647623 @default.
- W2015614056 date "2014-06-25" @default.
- W2015614056 modified "2023-10-18" @default.
- W2015614056 title "Human Mesenchymal Stem Cells Modulate Inflammatory Cytokines after Spinal Cord Injury in Rat" @default.
- W2015614056 cites W1546774597 @default.
- W2015614056 cites W1964772955 @default.
- W2015614056 cites W1967369695 @default.
- W2015614056 cites W1970024238 @default.
- W2015614056 cites W1982309486 @default.
- W2015614056 cites W1984612292 @default.
- W2015614056 cites W1988375959 @default.
- W2015614056 cites W1998779047 @default.
- W2015614056 cites W2010788195 @default.
- W2015614056 cites W2015116639 @default.
- W2015614056 cites W2016744980 @default.
- W2015614056 cites W2022964751 @default.
- W2015614056 cites W2026087788 @default.
- W2015614056 cites W2029561126 @default.
- W2015614056 cites W2034726354 @default.
- W2015614056 cites W2045701198 @default.
- W2015614056 cites W2046079188 @default.
- W2015614056 cites W2047003893 @default.
- W2015614056 cites W2062366535 @default.
- W2015614056 cites W20647727 @default.
- W2015614056 cites W2069399162 @default.
- W2015614056 cites W2078457923 @default.
- W2015614056 cites W2080260073 @default.
- W2015614056 cites W2080950947 @default.
- W2015614056 cites W2091585271 @default.
- W2015614056 cites W2093709488 @default.
- W2015614056 cites W2096785977 @default.
- W2015614056 cites W2106647511 @default.
- W2015614056 cites W2113860368 @default.
- W2015614056 cites W2119621864 @default.
- W2015614056 cites W2123292162 @default.
- W2015614056 cites W2124704309 @default.
- W2015614056 cites W2136319115 @default.
- W2015614056 cites W2136658778 @default.
- W2015614056 cites W2156969855 @default.
- W2015614056 cites W2169406173 @default.
- W2015614056 cites W2170645579 @default.
- W2015614056 cites W2317235122 @default.
- W2015614056 doi "https://doi.org/10.3390/ijms150711275" @default.
- W2015614056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4139782" @default.
- W2015614056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24968269" @default.
- W2015614056 hasPublicationYear "2014" @default.
- W2015614056 type Work @default.
- W2015614056 sameAs 2015614056 @default.
- W2015614056 citedByCount "93" @default.
- W2015614056 countsByYear W20156140562014 @default.
- W2015614056 countsByYear W20156140562015 @default.
- W2015614056 countsByYear W20156140562016 @default.
- W2015614056 countsByYear W20156140562017 @default.
- W2015614056 countsByYear W20156140562018 @default.
- W2015614056 countsByYear W20156140562019 @default.
- W2015614056 countsByYear W20156140562020 @default.
- W2015614056 countsByYear W20156140562021 @default.
- W2015614056 countsByYear W20156140562022 @default.
- W2015614056 countsByYear W20156140562023 @default.
- W2015614056 crossrefType "journal-article" @default.
- W2015614056 hasAuthorship W2015614056A5000968218 @default.
- W2015614056 hasAuthorship W2015614056A5004335610 @default.
- W2015614056 hasAuthorship W2015614056A5007470850 @default.
- W2015614056 hasAuthorship W2015614056A5025520471 @default.
- W2015614056 hasAuthorship W2015614056A5065203934 @default.
- W2015614056 hasAuthorship W2015614056A5067795929 @default.
- W2015614056 hasAuthorship W2015614056A5070295349 @default.
- W2015614056 hasAuthorship W2015614056A5081252742 @default.
- W2015614056 hasAuthorship W2015614056A5081690507 @default.
- W2015614056 hasAuthorship W2015614056A5084647623 @default.
- W2015614056 hasBestOaLocation W20156140561 @default.
- W2015614056 hasConcept C118552586 @default.
- W2015614056 hasConcept C126322002 @default.
- W2015614056 hasConcept C141071460 @default.
- W2015614056 hasConcept C142724271 @default.
- W2015614056 hasConcept C171056886 @default.
- W2015614056 hasConcept C198826908 @default.
- W2015614056 hasConcept C2777594495 @default.
- W2015614056 hasConcept C2778334475 @default.
- W2015614056 hasConcept C2779965356 @default.
- W2015614056 hasConcept C2780775167 @default.
- W2015614056 hasConcept C28328180 @default.
- W2015614056 hasConcept C2911091166 @default.
- W2015614056 hasConcept C529278444 @default.
- W2015614056 hasConcept C71924100 @default.
- W2015614056 hasConcept C86803240 @default.
- W2015614056 hasConcept C95444343 @default.