FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015617985> ?p ?o ?g. }

• W2015617985 endingPage "175" @default.
• W2015617985 startingPage "165" @default.
• W2015617985 abstract "Graft-versus-host disease (GVHD) is the most common complication after hematopoietic stem cell transplantation. To clarify the role of Toll-like receptor 4 (TLR4), which is a major receptor for bacterial lipopolysaccharides (LPS), in the development of acute GVHD, we used a TLR4-knockout (TLR4−/−) mouse GVHD model and analyzed the underlying immunological mechanisms. When TLR4−/− mice were used as bone marrow and splenocyte cell graft donors or recipients, GVHD symptom occurrence and mortality were delayed compared to wild-type (TLR4+/+) mice. In addition, histopathological analyses revealed that in TLR4−/−→BALB/c chimeras, liver and small intestine tissue damage was reduced with minimal lymphocytic infiltration. In contrast to TLR4+/+, TLR4−/− mice dendritic cells did not express CD80, CD86, CD40, MHC-II or IL-12 during LPS induction and remained in an immature state. Furthermore, the ability of TLR4−/− mice spleen dendritic cells to promote allogeneic T-cell proliferation and, in particular, T-helper cell 1 (Th1) development was obviously attenuated compared with TLR4+/+ mice dendritic cells, and the levels of interferon-γ (IFN-γ) and IL-10, Th2-cell specific cytokines, were significantly higher in the serum of TLR4−/−→BALB/c than in TLR4+/+→BALB/c chimeric mice. Overall, our data revealed that TLR4 may play a role in the pathogenesis of GVHD and that targeted TLR4 gene therapy might provide a new treatment approach to reduce the risk of GVHD." @default.
• W2015617985 created "2016-06-24" @default.
• W2015617985 creator A5014466817 @default.
• W2015617985 creator A5017242310 @default.
• W2015617985 creator A5019315614 @default.
• W2015617985 creator A5019681762 @default.
• W2015617985 creator A5023378337 @default.
• W2015617985 creator A5039161381 @default.
• W2015617985 creator A5049692788 @default.
• W2015617985 creator A5072588823 @default.
• W2015617985 creator A5073435344 @default.
• W2015617985 creator A5076516025 @default.
• W2015617985 creator A5080823558 @default.
• W2015617985 creator A5082780539 @default.
• W2015617985 creator A5089639451 @default.
• W2015617985 creator A5089986341 @default.
• W2015617985 date "2012-12-24" @default.
• W2015617985 modified "2023-10-12" @default.
• W2015617985 title "TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantation" @default.
• W2015617985 cites W1507468159 @default.
• W2015617985 cites W1544331058 @default.
• W2015617985 cites W1577886890 @default.
• W2015617985 cites W1966948793 @default.
• W2015617985 cites W1968927930 @default.
• W2015617985 cites W1972295901 @default.
• W2015617985 cites W1972835435 @default.
• W2015617985 cites W1975310253 @default.
• W2015617985 cites W1975655698 @default.
• W2015617985 cites W1977665068 @default.
• W2015617985 cites W1978926805 @default.
• W2015617985 cites W1986652997 @default.
• W2015617985 cites W2004657695 @default.
• W2015617985 cites W2006865619 @default.
• W2015617985 cites W2010438746 @default.
• W2015617985 cites W2015784912 @default.
• W2015617985 cites W2024015921 @default.
• W2015617985 cites W2024702107 @default.
• W2015617985 cites W2033384515 @default.
• W2015617985 cites W2034952320 @default.
• W2015617985 cites W2039817295 @default.
• W2015617985 cites W2043317121 @default.
• W2015617985 cites W2050444114 @default.
• W2015617985 cites W2054124482 @default.
• W2015617985 cites W2055808408 @default.
• W2015617985 cites W2062835892 @default.
• W2015617985 cites W2063871323 @default.
• W2015617985 cites W2066232478 @default.
• W2015617985 cites W2067308312 @default.
• W2015617985 cites W2085927114 @default.
• W2015617985 cites W2087372329 @default.
• W2015617985 cites W2094840790 @default.
• W2015617985 cites W2099601953 @default.
• W2015617985 cites W2109439232 @default.
• W2015617985 cites W2110760781 @default.
• W2015617985 cites W2112163076 @default.
• W2015617985 cites W2121797213 @default.
• W2015617985 cites W2132999369 @default.
• W2015617985 cites W2138651252 @default.
• W2015617985 cites W2160978572 @default.
• W2015617985 cites W2321580288 @default.
• W2015617985 doi "https://doi.org/10.1038/cmi.2012.58" @default.
• W2015617985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4003043" @default.
• W2015617985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23262974" @default.
• W2015617985 hasPublicationYear "2012" @default.
• W2015617985 type Work @default.
• W2015617985 sameAs 2015617985 @default.
• W2015617985 citedByCount "36" @default.
• W2015617985 countsByYear W20156179852014 @default.
• W2015617985 countsByYear W20156179852015 @default.
• W2015617985 countsByYear W20156179852016 @default.
• W2015617985 countsByYear W20156179852017 @default.
• W2015617985 countsByYear W20156179852018 @default.
• W2015617985 countsByYear W20156179852019 @default.
• W2015617985 countsByYear W20156179852020 @default.
• W2015617985 countsByYear W20156179852021 @default.
• W2015617985 countsByYear W20156179852022 @default.
• W2015617985 countsByYear W20156179852023 @default.
• W2015617985 crossrefType "journal-article" @default.
• W2015617985 hasAuthorship W2015617985A5014466817 @default.
• W2015617985 hasAuthorship W2015617985A5017242310 @default.
• W2015617985 hasAuthorship W2015617985A5019315614 @default.
• W2015617985 hasAuthorship W2015617985A5019681762 @default.
• W2015617985 hasAuthorship W2015617985A5023378337 @default.
• W2015617985 hasAuthorship W2015617985A5039161381 @default.
• W2015617985 hasAuthorship W2015617985A5049692788 @default.
• W2015617985 hasAuthorship W2015617985A5072588823 @default.
• W2015617985 hasAuthorship W2015617985A5073435344 @default.
• W2015617985 hasAuthorship W2015617985A5076516025 @default.
• W2015617985 hasAuthorship W2015617985A5080823558 @default.
• W2015617985 hasAuthorship W2015617985A5082780539 @default.
• W2015617985 hasAuthorship W2015617985A5089639451 @default.
• W2015617985 hasAuthorship W2015617985A5089986341 @default.
• W2015617985 hasBestOaLocation W20156179851 @default.
• W2015617985 hasConcept C126322002 @default.
• W2015617985 hasConcept C154317977 @default.
• W2015617985 hasConcept C202751555 @default.
• W2015617985 hasConcept C203014093 @default.
• W2015617985 hasConcept C2776070231 @default.

• next