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• W2015626410 endingPage "15" @default.
• W2015626410 startingPage "1" @default.
• W2015626410 abstract "Immunosuppressive agents are used for treatment of a variety of autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosis (SLE), and psoriasis, as well as for prevention of tissue rejection after organ transplantation. Recrudescence of herpesvirus infections, and increased risk of carcinogenesis from herpesvirus-associated tumors are related with immunosuppressive therapy in humans. Post-transplant lymphoproliferative disorder (PTLD), a condition characterized by development of Epstein Barr Virus (EBV)-associated B-lymphocyte lymphoma, and Kaposi’s Sarcoma (KS), a dermal tumor associated with Kaposi Sarcoma-associated virus (KSHV), may develop in solid organ transplant patients. KS also occurs in immunosuppressed Acquired Immunodeficiency (AIDS) patients. Kaposi Sarcoma-associated virus (KSHV) is a herpes virus genetically related to EBV. Murine gammaherpes-virus-68 (MHV-68) is proposed as a mouse model of gammaherpesvirus infection and recrudescence and may potentially have relevance for herpesvirus-associated neoplasia. The pathogenesis of MHV-68 infection in mice mimics EBV/KSHV infection in humans with acute lytic viral replication followed by dissemination and establishment of persistent latency. MHV-68-infected mice may develop lymphoproliferative disease that is accelerated by disruption of the immune system. This manuscript first presents an overview of gammaherpesvirus pathogenesis and immunology as well as factors involved in viral recrudescence. A description of different types of immunodeficiency then follows, with particular focus on viral association with lymphomagenesis after immunosuppression. Finally, this review discusses different gammaherpesvirus animal models and describes a proposed MHV-68 model to further examine the interplay of immunomodulatory agents and gammaherpesvirus-associated neoplasia." @default.
• W2015626410 created "2016-06-24" @default.
• W2015626410 creator A5014150213 @default.
• W2015626410 creator A5029344452 @default.
• W2015626410 creator A5035283317 @default.
• W2015626410 creator A5058372115 @default.
• W2015626410 date "2014-02-10" @default.
• W2015626410 modified "2023-09-30" @default.
• W2015626410 title "Is murine gammaherpesvirus-68 (MHV-68) a suitable immunotoxicological model for examining immunomodulatory drug-associated viral recrudescence?" @default.
• W2015626410 cites W141770798 @default.
• W2015626410 cites W1486561977 @default.
• W2015626410 cites W1530958543 @default.
• W2015626410 cites W1551986531 @default.
• W2015626410 cites W1568866013 @default.
• W2015626410 cites W1609504261 @default.
• W2015626410 cites W1633682654 @default.
• W2015626410 cites W1637768343 @default.
• W2015626410 cites W1667673594 @default.
• W2015626410 cites W1754574375 @default.
• W2015626410 cites W1891937459 @default.
• W2015626410 cites W1935097178 @default.
• W2015626410 cites W1946172505 @default.
• W2015626410 cites W1964899178 @default.
• W2015626410 cites W1965555285 @default.
• W2015626410 cites W1969498816 @default.
• W2015626410 cites W1969530715 @default.
• W2015626410 cites W1974186490 @default.
• W2015626410 cites W1976337084 @default.
• W2015626410 cites W1976701849 @default.
• W2015626410 cites W1977728770 @default.
• W2015626410 cites W1978001038 @default.
• W2015626410 cites W1979401674 @default.
• W2015626410 cites W1979601249 @default.
• W2015626410 cites W1983386156 @default.
• W2015626410 cites W1986191687 @default.
• W2015626410 cites W1987658986 @default.
• W2015626410 cites W1988279733 @default.
• W2015626410 cites W1988472957 @default.
• W2015626410 cites W1988795205 @default.
• W2015626410 cites W1991140047 @default.
• W2015626410 cites W1994887878 @default.
• W2015626410 cites W1999253174 @default.
• W2015626410 cites W2000061210 @default.
• W2015626410 cites W2002277984 @default.
• W2015626410 cites W2005081501 @default.
• W2015626410 cites W2007400424 @default.
• W2015626410 cites W2008570169 @default.
• W2015626410 cites W2008697983 @default.
• W2015626410 cites W2010586398 @default.
• W2015626410 cites W2012258036 @default.
• W2015626410 cites W2013041881 @default.
• W2015626410 cites W2014697836 @default.
• W2015626410 cites W2016711597 @default.
• W2015626410 cites W2017413052 @default.
• W2015626410 cites W2022659649 @default.
• W2015626410 cites W2024185937 @default.
• W2015626410 cites W2026565646 @default.
• W2015626410 cites W2028292318 @default.
• W2015626410 cites W2029107624 @default.
• W2015626410 cites W2032438721 @default.
• W2015626410 cites W2034605649 @default.
• W2015626410 cites W2038328664 @default.
• W2015626410 cites W2038782272 @default.
• W2015626410 cites W2039627762 @default.
• W2015626410 cites W2040839183 @default.
• W2015626410 cites W2045431047 @default.
• W2015626410 cites W2047288254 @default.
• W2015626410 cites W2053508150 @default.
• W2015626410 cites W2053737559 @default.
• W2015626410 cites W2053880113 @default.
• W2015626410 cites W2058268968 @default.
• W2015626410 cites W2065866793 @default.
• W2015626410 cites W2066610233 @default.
• W2015626410 cites W2067736783 @default.
• W2015626410 cites W2072047081 @default.
• W2015626410 cites W2074033973 @default.
• W2015626410 cites W2074372927 @default.
• W2015626410 cites W2075084453 @default.
• W2015626410 cites W2075665989 @default.
• W2015626410 cites W2076665646 @default.
• W2015626410 cites W2077210336 @default.
• W2015626410 cites W2078057624 @default.
• W2015626410 cites W2080542109 @default.
• W2015626410 cites W2081651119 @default.
• W2015626410 cites W2081920416 @default.
• W2015626410 cites W2083891617 @default.
• W2015626410 cites W2085483635 @default.
• W2015626410 cites W2086517030 @default.
• W2015626410 cites W2088428578 @default.
• W2015626410 cites W2089470376 @default.
• W2015626410 cites W2094144752 @default.
• W2015626410 cites W2097174115 @default.
• W2015626410 cites W2100106672 @default.
• W2015626410 cites W2101363646 @default.
• W2015626410 cites W2102274616 @default.
• W2015626410 cites W2102323376 @default.
• W2015626410 cites W2102512316 @default.
• W2015626410 cites W2103717331 @default.

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