Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015638452> ?p ?o ?g. }
- W2015638452 endingPage "189" @default.
- W2015638452 startingPage "182" @default.
- W2015638452 abstract "Acute fatty liver of pregnancy (AFLP) and the syndrome of hemolysis, elevated liver enzymes, and low platelets (the HELLP syndrome) are serious disorders of the third trimester with high maternal and perinatal morbidity and mortality. Over the past decade, several clinical observations have demonstrated an association between these maternal syndromes and a recessively inherited fatty acid oxidation disorder, long chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency. Many women who carried LCHAD-deficient fetuses developed maternal liver disease. Over the past few years, we and others have made significant progress in understanding the molecular basis for this fetal-maternal interaction. Here, we review the studies in literature that led to the establishment of this causative association with particular emphasis on the molecular analysis that delineated the molecular basis of this association. The likely mechanisms for the genotype-phenotype correlations in pediatric LCHAD deficiency and the fetal-maternal interaction are discussed. Finally, the potential implications of our current knowledge for families with pediatric LCHAD deficiency and for women who develop AFLP and HELLP syndrome are discussed." @default.
- W2015638452 created "2016-06-24" @default.
- W2015638452 creator A5031711759 @default.
- W2015638452 creator A5046089256 @default.
- W2015638452 creator A5071225626 @default.
- W2015638452 date "2000-09-01" @default.
- W2015638452 modified "2023-10-15" @default.
- W2015638452 title "Liver Disease in Pregnancy and Fetal Fatty Acid Oxidation Defects" @default.
- W2015638452 cites W1510158417 @default.
- W2015638452 cites W1724708078 @default.
- W2015638452 cites W1967757221 @default.
- W2015638452 cites W1968853872 @default.
- W2015638452 cites W1972986664 @default.
- W2015638452 cites W1982573346 @default.
- W2015638452 cites W1993127448 @default.
- W2015638452 cites W1997031349 @default.
- W2015638452 cites W2003397776 @default.
- W2015638452 cites W2003661489 @default.
- W2015638452 cites W2004559376 @default.
- W2015638452 cites W2009017468 @default.
- W2015638452 cites W2009388851 @default.
- W2015638452 cites W2023165455 @default.
- W2015638452 cites W2028409024 @default.
- W2015638452 cites W2030403616 @default.
- W2015638452 cites W2030802624 @default.
- W2015638452 cites W2031780611 @default.
- W2015638452 cites W2037461784 @default.
- W2015638452 cites W2038207656 @default.
- W2015638452 cites W2050100823 @default.
- W2015638452 cites W2054334375 @default.
- W2015638452 cites W2055397215 @default.
- W2015638452 cites W2063668518 @default.
- W2015638452 cites W2071481043 @default.
- W2015638452 cites W2073703809 @default.
- W2015638452 cites W2074435742 @default.
- W2015638452 cites W2075694342 @default.
- W2015638452 cites W2077975666 @default.
- W2015638452 cites W2083753177 @default.
- W2015638452 cites W2092077589 @default.
- W2015638452 cites W2093820518 @default.
- W2015638452 cites W2100153998 @default.
- W2015638452 cites W2104262874 @default.
- W2015638452 cites W2114245152 @default.
- W2015638452 cites W2123209943 @default.
- W2015638452 cites W2150710988 @default.
- W2015638452 cites W2158807341 @default.
- W2015638452 cites W2337873021 @default.
- W2015638452 cites W4245637767 @default.
- W2015638452 doi "https://doi.org/10.1006/mgme.2000.3065" @default.
- W2015638452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11001809" @default.
- W2015638452 hasPublicationYear "2000" @default.
- W2015638452 type Work @default.
- W2015638452 sameAs 2015638452 @default.
- W2015638452 citedByCount "100" @default.
- W2015638452 countsByYear W20156384522012 @default.
- W2015638452 countsByYear W20156384522013 @default.
- W2015638452 countsByYear W20156384522014 @default.
- W2015638452 countsByYear W20156384522015 @default.
- W2015638452 countsByYear W20156384522016 @default.
- W2015638452 countsByYear W20156384522017 @default.
- W2015638452 countsByYear W20156384522018 @default.
- W2015638452 countsByYear W20156384522019 @default.
- W2015638452 countsByYear W20156384522021 @default.
- W2015638452 countsByYear W20156384522022 @default.
- W2015638452 countsByYear W20156384522023 @default.
- W2015638452 crossrefType "journal-article" @default.
- W2015638452 hasAuthorship W2015638452A5031711759 @default.
- W2015638452 hasAuthorship W2015638452A5046089256 @default.
- W2015638452 hasAuthorship W2015638452A5071225626 @default.
- W2015638452 hasConcept C126322002 @default.
- W2015638452 hasConcept C131872663 @default.
- W2015638452 hasConcept C172680121 @default.
- W2015638452 hasConcept C2777218350 @default.
- W2015638452 hasConcept C2777774211 @default.
- W2015638452 hasConcept C2778772119 @default.
- W2015638452 hasConcept C2779134260 @default.
- W2015638452 hasConcept C2779234561 @default.
- W2015638452 hasConcept C2779902561 @default.
- W2015638452 hasConcept C2780537801 @default.
- W2015638452 hasConcept C42407357 @default.
- W2015638452 hasConcept C54355233 @default.
- W2015638452 hasConcept C71924100 @default.
- W2015638452 hasConcept C86803240 @default.
- W2015638452 hasConceptScore W2015638452C126322002 @default.
- W2015638452 hasConceptScore W2015638452C131872663 @default.
- W2015638452 hasConceptScore W2015638452C172680121 @default.
- W2015638452 hasConceptScore W2015638452C2777218350 @default.
- W2015638452 hasConceptScore W2015638452C2777774211 @default.
- W2015638452 hasConceptScore W2015638452C2778772119 @default.
- W2015638452 hasConceptScore W2015638452C2779134260 @default.
- W2015638452 hasConceptScore W2015638452C2779234561 @default.
- W2015638452 hasConceptScore W2015638452C2779902561 @default.
- W2015638452 hasConceptScore W2015638452C2780537801 @default.
- W2015638452 hasConceptScore W2015638452C42407357 @default.
- W2015638452 hasConceptScore W2015638452C54355233 @default.
- W2015638452 hasConceptScore W2015638452C71924100 @default.
- W2015638452 hasConceptScore W2015638452C86803240 @default.
- W2015638452 hasIssue "1-2" @default.