FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015640010> ?p ?o ?g. }

• W2015640010 abstract "Cardiomyocytic apoptosis occurs after cardiopulmonary bypass (CPB) despite the use of perfusion techniques and cardioplegic solutions. Reactive oxygen species (ROS) cause single-strand DNA breaks and activate nuclear poly(ADP-ribose) polymerase (PARP), which leads to cellular damage. Therefore, the inhibition of PARP might protect cardiomyocytes from oxidative injuries. In this study, experiments were designed to determine whether a PARP inhibitor could decrease the myocardial ischemia/reperfusion injury after cardioplegia-induced global cardiac arrest under CPB, attenuate the appearance of cardiomyocytic apoptosis, and decrease damage from ROS. New Zealand white rabbits (10 in each group) were subjected to total CPB. Rabbits were weaned from CPB and reperfused for 4 h before the hearts were harvested. 3-Aminobenzamide and/or 3-aminobenzoic acid was added to the cardioplegic solution. The ascending aorta was cross-clamped for 60 min while intermittent cold crystalloid cardioplegic solution was infused into the aortic root every 20 min. The reperfused hearts were harvested and studied for evidence of apoptosis using the TUNEL method and Western blot analyses. The oxidative insults were checked using ELISA to detect plasma isoprostane and cytokines levels. The occurrence of cardiomyocytic apoptosis was significantly less in PARP inhibitor recipients than in PARP-inhibitor-naive controls. Plasma isoprostane and various cytokines were significantly elevated in PARP-inhibitor-naive controls but significantly reduced in PARP inhibitor recipients. Western blot analysis revealed similar patterns. PARP inhibitor-supplemented crystalloid cardioplegic solution diminished postischemic cardiomyocytic apoptosis and ROS-mediated injuries after global cardiac arrest under CPB, possibly via inhibiting both caspase-dependent and -independent apoptotic pathways, which also preserved postischemic myocardial contractility." @default.
• W2015640010 created "2016-06-24" @default.
• W2015640010 creator A5010799034 @default.
• W2015640010 creator A5015757803 @default.
• W2015640010 creator A5028715974 @default.
• W2015640010 creator A5030223507 @default.
• W2015640010 creator A5040346411 @default.
• W2015640010 creator A5089055123 @default.
• W2015640010 date "2006-02-01" @default.
• W2015640010 modified "2023-10-17" @default.
• W2015640010 title "INHIBITION OF POLY(ADP-RIBOSE) POLYMERASE REDUCES CARDIOMYOCYTIC APOPTOSIS AFTER GLOBAL CARDIAC ARREST UNDER CARDIOPULMONARY BYPASS" @default.
• W2015640010 cites W1574945736 @default.
• W2015640010 cites W1904882776 @default.
• W2015640010 cites W1966928113 @default.
• W2015640010 cites W1970964516 @default.
• W2015640010 cites W1974725853 @default.
• W2015640010 cites W1975255909 @default.
• W2015640010 cites W1978844772 @default.
• W2015640010 cites W1992476369 @default.
• W2015640010 cites W1996180957 @default.
• W2015640010 cites W2016568695 @default.
• W2015640010 cites W2019278298 @default.
• W2015640010 cites W2033079929 @default.
• W2015640010 cites W2040107240 @default.
• W2015640010 cites W2046816386 @default.
• W2015640010 cites W2050614205 @default.
• W2015640010 cites W2052855638 @default.
• W2015640010 cites W2066459570 @default.
• W2015640010 cites W2067581325 @default.
• W2015640010 cites W2075454634 @default.
• W2015640010 cites W2078849576 @default.
• W2015640010 cites W2093814798 @default.
• W2015640010 cites W2096741239 @default.
• W2015640010 cites W2099883737 @default.
• W2015640010 cites W2099904057 @default.
• W2015640010 cites W2102150242 @default.
• W2015640010 cites W2116118256 @default.
• W2015640010 cites W2135386592 @default.
• W2015640010 cites W2136956854 @default.
• W2015640010 cites W2137834530 @default.
• W2015640010 cites W2157016693 @default.
• W2015640010 cites W2159181061 @default.
• W2015640010 cites W2159650080 @default.
• W2015640010 cites W2165010546 @default.
• W2015640010 cites W2166250944 @default.
• W2015640010 cites W31767841 @default.
• W2015640010 cites W4234971544 @default.
• W2015640010 cites W4249393610 @default.
• W2015640010 doi "https://doi.org/10.1097/01.shk.0000188709.04777.48" @default.
• W2015640010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16525356" @default.
• W2015640010 hasPublicationYear "2006" @default.
• W2015640010 type Work @default.
• W2015640010 sameAs 2015640010 @default.
• W2015640010 citedByCount "15" @default.
• W2015640010 countsByYear W20156400102015 @default.
• W2015640010 countsByYear W20156400102017 @default.
• W2015640010 countsByYear W20156400102020 @default.
• W2015640010 countsByYear W20156400102021 @default.
• W2015640010 crossrefType "journal-article" @default.
• W2015640010 hasAuthorship W2015640010A5010799034 @default.
• W2015640010 hasAuthorship W2015640010A5015757803 @default.
• W2015640010 hasAuthorship W2015640010A5028715974 @default.
• W2015640010 hasAuthorship W2015640010A5030223507 @default.
• W2015640010 hasAuthorship W2015640010A5040346411 @default.
• W2015640010 hasAuthorship W2015640010A5089055123 @default.
• W2015640010 hasConcept C104317684 @default.
• W2015640010 hasConcept C126322002 @default.
• W2015640010 hasConcept C182979987 @default.
• W2015640010 hasConcept C185592680 @default.
• W2015640010 hasConcept C190283241 @default.
• W2015640010 hasConcept C196795494 @default.
• W2015640010 hasConcept C2776151105 @default.
• W2015640010 hasConcept C2776415932 @default.
• W2015640010 hasConcept C2778881276 @default.
• W2015640010 hasConcept C42219234 @default.
• W2015640010 hasConcept C48349386 @default.
• W2015640010 hasConcept C55493867 @default.
• W2015640010 hasConcept C71924100 @default.
• W2015640010 hasConcept C82381507 @default.
• W2015640010 hasConcept C98274493 @default.
• W2015640010 hasConceptScore W2015640010C104317684 @default.
• W2015640010 hasConceptScore W2015640010C126322002 @default.
• W2015640010 hasConceptScore W2015640010C182979987 @default.
• W2015640010 hasConceptScore W2015640010C185592680 @default.
• W2015640010 hasConceptScore W2015640010C190283241 @default.
• W2015640010 hasConceptScore W2015640010C196795494 @default.
• W2015640010 hasConceptScore W2015640010C2776151105 @default.
• W2015640010 hasConceptScore W2015640010C2776415932 @default.
• W2015640010 hasConceptScore W2015640010C2778881276 @default.
• W2015640010 hasConceptScore W2015640010C42219234 @default.
• W2015640010 hasConceptScore W2015640010C48349386 @default.
• W2015640010 hasConceptScore W2015640010C55493867 @default.
• W2015640010 hasConceptScore W2015640010C71924100 @default.
• W2015640010 hasConceptScore W2015640010C82381507 @default.
• W2015640010 hasConceptScore W2015640010C98274493 @default.
• W2015640010 hasLocation W20156400101 @default.
• W2015640010 hasLocation W20156400102 @default.
• W2015640010 hasOpenAccess W2015640010 @default.
• W2015640010 hasPrimaryLocation W20156400101 @default.
• W2015640010 hasRelatedWork W2023082526 @default.

• next