FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015647110> ?p ?o ?g. }

• W2015647110 endingPage "2026" @default.
• W2015647110 startingPage "2017" @default.
• W2015647110 abstract "The herpes simplex virus (HSV) amplicon vector is a powerful gene delivery vehicle that can accommodate up to 150 kilobase of exogenous DNA. However, amplicon-mediated transgene expression is often transient outside the nervous system. In order to define the role of host immune responses in silencing amplicon-encoded transgenes, we evaluated the kinetics of cytokine-/chemokine-expression after tail-vein injection of a luciferase-encoding amplicon into mice. Type I interferons (IFNs) were induced earliest, within an hour after injection, and several other cytokines/chemokines were subsequently upregulated in the livers of wild-type (WT) mice. When the same experiment was performed in signal transducers and activators of transcription 1 (STAT1)-knockout (KO) mice, the levels of type I IFN expression were significantly lower and chemokine induction was almost non-existent. Importantly, STAT1-KO mice exhibited significantly higher and more sustained luciferase activity than did the WT mice, which is attributable to increased transcriptional activity rather than increased copy numbers of luciferase-encoding vector DNA. Further studies using primary cultured fibroblasts derived from WT and STAT1-KO mice revealed the significance of STAT1 signaling in transcriptional silencing of the amplicon-encoded transgene in vitro. Our results indicate that type I IFNs induced by systemic delivery of HSV amplicon vectors initiate a cascade of immune responses and suppress transgene expression at the transcriptional level by activation of STAT1." @default.
• W2015647110 created "2016-06-24" @default.
• W2015647110 creator A5033917464 @default.
• W2015647110 creator A5065678645 @default.
• W2015647110 creator A5070498790 @default.
• W2015647110 date "2007-11-01" @default.
• W2015647110 modified "2023-10-16" @default.
• W2015647110 title "Early STAT1 Activation After Systemic Delivery of HSV Amplicon Vectors Suppresses Transcription of The Vector-encoded Transgene" @default.
• W2015647110 cites W1523770800 @default.
• W2015647110 cites W1566038373 @default.
• W2015647110 cites W1583992601 @default.
• W2015647110 cites W1778677407 @default.
• W2015647110 cites W1964340993 @default.
• W2015647110 cites W1968788087 @default.
• W2015647110 cites W1970551361 @default.
• W2015647110 cites W1976555683 @default.
• W2015647110 cites W1981369720 @default.
• W2015647110 cites W1990235635 @default.
• W2015647110 cites W1991711092 @default.
• W2015647110 cites W1996916131 @default.
• W2015647110 cites W2004101061 @default.
• W2015647110 cites W2004465286 @default.
• W2015647110 cites W2015221134 @default.
• W2015647110 cites W2028645756 @default.
• W2015647110 cites W2036887222 @default.
• W2015647110 cites W2048162805 @default.
• W2015647110 cites W2049685571 @default.
• W2015647110 cites W2054891682 @default.
• W2015647110 cites W2063511353 @default.
• W2015647110 cites W2068976846 @default.
• W2015647110 cites W2072421057 @default.
• W2015647110 cites W2074238518 @default.
• W2015647110 cites W2079357798 @default.
• W2015647110 cites W2088534886 @default.
• W2015647110 cites W2091658754 @default.
• W2015647110 cites W2104045882 @default.
• W2015647110 cites W2105118305 @default.
• W2015647110 cites W2109366007 @default.
• W2015647110 cites W2118519588 @default.
• W2015647110 cites W2123073376 @default.
• W2015647110 cites W2139405922 @default.
• W2015647110 cites W2140902312 @default.
• W2015647110 cites W2155334466 @default.
• W2015647110 cites W2158562032 @default.
• W2015647110 cites W2789734241 @default.
• W2015647110 doi "https://doi.org/10.1038/sj.mt.6300273" @default.
• W2015647110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17653098" @default.
• W2015647110 hasPublicationYear "2007" @default.
• W2015647110 type Work @default.
• W2015647110 sameAs 2015647110 @default.
• W2015647110 citedByCount "22" @default.
• W2015647110 countsByYear W20156471102012 @default.
• W2015647110 countsByYear W20156471102013 @default.
• W2015647110 countsByYear W20156471102014 @default.
• W2015647110 countsByYear W20156471102017 @default.
• W2015647110 countsByYear W20156471102022 @default.
• W2015647110 crossrefType "journal-article" @default.
• W2015647110 hasAuthorship W2015647110A5033917464 @default.
• W2015647110 hasAuthorship W2015647110A5065678645 @default.
• W2015647110 hasAuthorship W2015647110A5070498790 @default.
• W2015647110 hasBestOaLocation W20156471101 @default.
• W2015647110 hasConcept C102230213 @default.
• W2015647110 hasConcept C104317684 @default.
• W2015647110 hasConcept C111335760 @default.
• W2015647110 hasConcept C119056186 @default.
• W2015647110 hasConcept C13373296 @default.
• W2015647110 hasConcept C138885662 @default.
• W2015647110 hasConcept C153911025 @default.
• W2015647110 hasConcept C179926584 @default.
• W2015647110 hasConcept C203014093 @default.
• W2015647110 hasConcept C2777003663 @default.
• W2015647110 hasConcept C32470452 @default.
• W2015647110 hasConcept C40767141 @default.
• W2015647110 hasConcept C41895202 @default.
• W2015647110 hasConcept C49105822 @default.
• W2015647110 hasConcept C54009773 @default.
• W2015647110 hasConcept C54355233 @default.
• W2015647110 hasConcept C62478195 @default.
• W2015647110 hasConcept C8185291 @default.
• W2015647110 hasConcept C86803240 @default.
• W2015647110 hasConcept C8891405 @default.
• W2015647110 hasConcept C95444343 @default.
• W2015647110 hasConceptScore W2015647110C102230213 @default.
• W2015647110 hasConceptScore W2015647110C104317684 @default.
• W2015647110 hasConceptScore W2015647110C111335760 @default.
• W2015647110 hasConceptScore W2015647110C119056186 @default.
• W2015647110 hasConceptScore W2015647110C13373296 @default.
• W2015647110 hasConceptScore W2015647110C138885662 @default.
• W2015647110 hasConceptScore W2015647110C153911025 @default.
• W2015647110 hasConceptScore W2015647110C179926584 @default.
• W2015647110 hasConceptScore W2015647110C203014093 @default.
• W2015647110 hasConceptScore W2015647110C2777003663 @default.
• W2015647110 hasConceptScore W2015647110C32470452 @default.
• W2015647110 hasConceptScore W2015647110C40767141 @default.
• W2015647110 hasConceptScore W2015647110C41895202 @default.
• W2015647110 hasConceptScore W2015647110C49105822 @default.
• W2015647110 hasConceptScore W2015647110C54009773 @default.
• W2015647110 hasConceptScore W2015647110C54355233 @default.

• next