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• W2015650257 abstract "Dihydropyrazino-quinazolinedione chemotypes are complex and structurally challenging structures of biological interest, being found in the marine alkaloids such as brevianamide M–N and fumiquinazolines A–C. Herein we report the synthesis of this tricyclic system in three synthetic operations by means of an Ugi multi-component reaction (MCR) followed by a tandem N-acyliminium ion cyclization-intramolecular nucleophilic addition reaction sequence. Additional structural diversification for further library enrichment was also accomplished via sequential N-alkylation and N-acylation/sulfonation." @default.
• W2015650257 created "2016-06-24" @default.
• W2015650257 creator A5032601962 @default.
• W2015650257 creator A5087134189 @default.
• W2015650257 date "2013-08-01" @default.
• W2015650257 modified "2023-09-23" @default.
• W2015650257 title "Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade" @default.
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• W2015650257 doi "https://doi.org/10.1016/j.tetlet.2013.06.042" @default.
• W2015650257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3755472" @default.
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