FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015651116> ?p ?o ?g. }

• W2015651116 endingPage "L785" @default.
• W2015651116 startingPage "L775" @default.
• W2015651116 abstract "Maturation of newly formed vessels is a multistep phenomenon during which functional endothelial barriers are established. Disruption of vessel integrity is an important feature in many physiological and pathological processes. We previously reported that lymphoblastic leukemia-derived sequence 1 (LYL1) is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. In this study, we show that LYL1 is also required during the formation of the mature endothelial barrier in the lungs of adult mice. Specifically, LYL1 knockdown in human endothelial cells downregulated the expression of ARHGAP21 and ARHGAP24, which encode two Rho GTPase-activating proteins, and this was correlated with increased RhoA activity and reorganization of the actin cytoskeleton into stress fibers. Importantly, in lungs of Lyl1-deficient mice, both vascular endothelial (VE)-cadherin and p120-catenin were poorly recruited to endothelial adherens junctions, indicative of defective cell-cell junctions. Consistent with this, higher Evans blue dye extravasation, edema, and leukocyte infiltration in the lung parenchyma of Lyl1-/- mice than in wild-type littermates confirmed that lung vascular permeability is constitutively elevated in Lyl1-/- adult mice. Our data show that LYL1 acts as a stabilizing signal for adherens junction formation by operating upstream of VE-cadherin and of the two GTPases Rap1 and RhoA. As increased vascular permeability is a key feature and a major mechanism of acute respiratory distress syndrome, molecules that regulate LYL1 activity could represent additional tools to modify the endothelial barrier permeability." @default.
• W2015651116 created "2016-06-24" @default.
• W2015651116 creator A5000921685 @default.
• W2015651116 creator A5007369201 @default.
• W2015651116 creator A5011162346 @default.
• W2015651116 creator A5021661270 @default.
• W2015651116 creator A5057203729 @default.
• W2015651116 creator A5071473214 @default.
• W2015651116 creator A5074464314 @default.
• W2015651116 creator A5080011731 @default.
• W2015651116 creator A5091508287 @default.
• W2015651116 date "2014-04-15" @default.
• W2015651116 modified "2023-10-18" @default.
• W2015651116 title "Lung endothelial barrier disruption in <i>Lyl1</i>-deficient mice" @default.
• W2015651116 cites W1583843945 @default.
• W2015651116 cites W1934202741 @default.
• W2015651116 cites W1963665728 @default.
• W2015651116 cites W1965660329 @default.
• W2015651116 cites W1968325292 @default.
• W2015651116 cites W1971826305 @default.
• W2015651116 cites W1981448346 @default.
• W2015651116 cites W1982584027 @default.
• W2015651116 cites W2010045296 @default.
• W2015651116 cites W2012690842 @default.
• W2015651116 cites W2028000765 @default.
• W2015651116 cites W2031610918 @default.
• W2015651116 cites W2035176010 @default.
• W2015651116 cites W2040210675 @default.
• W2015651116 cites W2041351060 @default.
• W2015651116 cites W2042570069 @default.
• W2015651116 cites W2050334374 @default.
• W2015651116 cites W2057253189 @default.
• W2015651116 cites W2057663938 @default.
• W2015651116 cites W2060504290 @default.
• W2015651116 cites W2065290189 @default.
• W2015651116 cites W2065433187 @default.
• W2015651116 cites W2067006419 @default.
• W2015651116 cites W2070309863 @default.
• W2015651116 cites W2072042116 @default.
• W2015651116 cites W2072889522 @default.
• W2015651116 cites W2078960496 @default.
• W2015651116 cites W2080157614 @default.
• W2015651116 cites W2081596239 @default.
• W2015651116 cites W2084147384 @default.
• W2015651116 cites W2085179400 @default.
• W2015651116 cites W2104198848 @default.
• W2015651116 cites W2105822318 @default.
• W2015651116 cites W2112281734 @default.
• W2015651116 cites W2116628576 @default.
• W2015651116 cites W2119227653 @default.
• W2015651116 cites W2121134435 @default.
• W2015651116 cites W2121914422 @default.
• W2015651116 cites W2122341732 @default.
• W2015651116 cites W2130136843 @default.
• W2015651116 cites W2146633546 @default.
• W2015651116 cites W2154785597 @default.
• W2015651116 cites W2163740123 @default.
• W2015651116 cites W2167078220 @default.
• W2015651116 cites W2170605386 @default.
• W2015651116 cites W2171003437 @default.
• W2015651116 cites W2240765188 @default.
• W2015651116 cites W2261467449 @default.
• W2015651116 cites W2316495406 @default.
• W2015651116 cites W4239031027 @default.
• W2015651116 doi "https://doi.org/10.1152/ajplung.00200.2013" @default.
• W2015651116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24532287" @default.
• W2015651116 hasPublicationYear "2014" @default.
• W2015651116 type Work @default.
• W2015651116 sameAs 2015651116 @default.
• W2015651116 citedByCount "17" @default.
• W2015651116 countsByYear W20156511162014 @default.
• W2015651116 countsByYear W20156511162015 @default.
• W2015651116 countsByYear W20156511162016 @default.
• W2015651116 countsByYear W20156511162017 @default.
• W2015651116 countsByYear W20156511162018 @default.
• W2015651116 countsByYear W20156511162020 @default.
• W2015651116 countsByYear W20156511162021 @default.
• W2015651116 countsByYear W20156511162022 @default.
• W2015651116 countsByYear W20156511162023 @default.
• W2015651116 crossrefType "journal-article" @default.
• W2015651116 hasAuthorship W2015651116A5000921685 @default.
• W2015651116 hasAuthorship W2015651116A5007369201 @default.
• W2015651116 hasAuthorship W2015651116A5011162346 @default.
• W2015651116 hasAuthorship W2015651116A5021661270 @default.
• W2015651116 hasAuthorship W2015651116A5057203729 @default.
• W2015651116 hasAuthorship W2015651116A5071473214 @default.
• W2015651116 hasAuthorship W2015651116A5074464314 @default.
• W2015651116 hasAuthorship W2015651116A5080011731 @default.
• W2015651116 hasAuthorship W2015651116A5091508287 @default.
• W2015651116 hasConcept C113045295 @default.
• W2015651116 hasConcept C123012128 @default.
• W2015651116 hasConcept C134018914 @default.
• W2015651116 hasConcept C142669718 @default.
• W2015651116 hasConcept C142724271 @default.
• W2015651116 hasConcept C1491633281 @default.
• W2015651116 hasConcept C149402561 @default.
• W2015651116 hasConcept C201508349 @default.
• W2015651116 hasConcept C202751555 @default.

• next