Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015653203> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2015653203 endingPage "539" @default.
- W2015653203 startingPage "535" @default.
- W2015653203 abstract "The present study was designed to investigate the effect of food and of a raised intragastric pH on the bioavailability of two prodrug beta-lactam, antibiotics, namely bacampicillin and cefuroxime axetil. Six healthy volunteers participated in an intraindividual comparison of absorption of (a) prodrug, (b) breakfast, followed by prodrug, (c) breakfast, ranitidine and sodium bicarbonate followed by prodrug, and (d) ranitidine and sodium bicarbonate, followed by prodrug. All volunteers were dosed with both bacampicillin and cefuroxime axetil under the above regimens. The drug-free periods between trials were 7 days. Blood samples were obtained before and 20, 40, 60, 90, 120, 150, 180, 210 min and 4, 5, 6, 8 and 10 h after administration. The urine was collected for a period of 10 h after dosing with the antibiotic. An estimation of the relative bioavailability of the drugs under the various regimens was made by comparing the average areas under the serum concentration time curves and also the amounts recovered in the urine. Both food and reduced gastric acidity decreased the bioavailability of bacampicillin (as ampicillin) and these variables had an additive lowering effect on the AUC and percentage urinary recovery. Possibly this ester becomes partially hydrolyzed prior to absorption on raising the intragastric pH. Adsorption onto food components or complexing with proteins may also play a role in the reduced bioavailability of bacampicillin in the presence of food. In contrast, the absorption of the cefuroxime ester was enhanced postprandially. This may be rationalized in terms of delayed gastric emptying and gastrointestinal transit which allows more complete dissolution or prolonged residence at the most favourable site of absorption in the intestine.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2015653203 created "2016-06-24" @default.
- W2015653203 creator A5018750189 @default.
- W2015653203 creator A5043723178 @default.
- W2015653203 creator A5059321966 @default.
- W2015653203 creator A5061953005 @default.
- W2015653203 date "1984-10-01" @default.
- W2015653203 modified "2023-10-14" @default.
- W2015653203 title "Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil." @default.
- W2015653203 cites W1954628149 @default.
- W2015653203 cites W1977082184 @default.
- W2015653203 cites W1978979619 @default.
- W2015653203 cites W1980766303 @default.
- W2015653203 cites W1986562893 @default.
- W2015653203 cites W2030318306 @default.
- W2015653203 cites W2043541709 @default.
- W2015653203 cites W2093555201 @default.
- W2015653203 cites W2408900839 @default.
- W2015653203 doi "https://doi.org/10.1111/j.1365-2125.1984.tb02501.x" @default.
- W2015653203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1463630" @default.
- W2015653203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6091711" @default.
- W2015653203 hasPublicationYear "1984" @default.
- W2015653203 type Work @default.
- W2015653203 sameAs 2015653203 @default.
- W2015653203 citedByCount "79" @default.
- W2015653203 countsByYear W20156532032012 @default.
- W2015653203 countsByYear W20156532032013 @default.
- W2015653203 countsByYear W20156532032014 @default.
- W2015653203 countsByYear W20156532032015 @default.
- W2015653203 countsByYear W20156532032016 @default.
- W2015653203 countsByYear W20156532032017 @default.
- W2015653203 countsByYear W20156532032018 @default.
- W2015653203 countsByYear W20156532032019 @default.
- W2015653203 countsByYear W20156532032020 @default.
- W2015653203 countsByYear W20156532032022 @default.
- W2015653203 crossrefType "journal-article" @default.
- W2015653203 hasAuthorship W2015653203A5018750189 @default.
- W2015653203 hasAuthorship W2015653203A5043723178 @default.
- W2015653203 hasAuthorship W2015653203A5059321966 @default.
- W2015653203 hasAuthorship W2015653203A5061953005 @default.
- W2015653203 hasBestOaLocation W20156532031 @default.
- W2015653203 hasConcept C108215921 @default.
- W2015653203 hasConcept C112705442 @default.
- W2015653203 hasConcept C147789679 @default.
- W2015653203 hasConcept C181389837 @default.
- W2015653203 hasConcept C185592680 @default.
- W2015653203 hasConcept C2776420369 @default.
- W2015653203 hasConcept C2777056448 @default.
- W2015653203 hasConcept C2777514703 @default.
- W2015653203 hasConcept C2779422922 @default.
- W2015653203 hasConcept C2780026642 @default.
- W2015653203 hasConcept C3020479747 @default.
- W2015653203 hasConcept C501593827 @default.
- W2015653203 hasConcept C55493867 @default.
- W2015653203 hasConcept C71924100 @default.
- W2015653203 hasConcept C77281830 @default.
- W2015653203 hasConcept C98274493 @default.
- W2015653203 hasConceptScore W2015653203C108215921 @default.
- W2015653203 hasConceptScore W2015653203C112705442 @default.
- W2015653203 hasConceptScore W2015653203C147789679 @default.
- W2015653203 hasConceptScore W2015653203C181389837 @default.
- W2015653203 hasConceptScore W2015653203C185592680 @default.
- W2015653203 hasConceptScore W2015653203C2776420369 @default.
- W2015653203 hasConceptScore W2015653203C2777056448 @default.
- W2015653203 hasConceptScore W2015653203C2777514703 @default.
- W2015653203 hasConceptScore W2015653203C2779422922 @default.
- W2015653203 hasConceptScore W2015653203C2780026642 @default.
- W2015653203 hasConceptScore W2015653203C3020479747 @default.
- W2015653203 hasConceptScore W2015653203C501593827 @default.
- W2015653203 hasConceptScore W2015653203C55493867 @default.
- W2015653203 hasConceptScore W2015653203C71924100 @default.
- W2015653203 hasConceptScore W2015653203C77281830 @default.
- W2015653203 hasConceptScore W2015653203C98274493 @default.
- W2015653203 hasIssue "4" @default.
- W2015653203 hasLocation W20156532031 @default.
- W2015653203 hasLocation W20156532032 @default.
- W2015653203 hasLocation W20156532033 @default.
- W2015653203 hasLocation W20156532034 @default.
- W2015653203 hasOpenAccess W2015653203 @default.
- W2015653203 hasPrimaryLocation W20156532031 @default.
- W2015653203 hasRelatedWork W1796348015 @default.
- W2015653203 hasRelatedWork W1970331292 @default.
- W2015653203 hasRelatedWork W2001333918 @default.
- W2015653203 hasRelatedWork W2012134758 @default.
- W2015653203 hasRelatedWork W2061323067 @default.
- W2015653203 hasRelatedWork W2086460393 @default.
- W2015653203 hasRelatedWork W2314489661 @default.
- W2015653203 hasRelatedWork W2317627837 @default.
- W2015653203 hasRelatedWork W2414263157 @default.
- W2015653203 hasRelatedWork W88005891 @default.
- W2015653203 hasVolume "18" @default.
- W2015653203 isParatext "false" @default.
- W2015653203 isRetracted "false" @default.
- W2015653203 magId "2015653203" @default.
- W2015653203 workType "article" @default.