FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015654015> ?p ?o ?g. }

• W2015654015 endingPage "1464" @default.
• W2015654015 startingPage "1457" @default.
• W2015654015 abstract "Restoration of functional endothelium is a requirement for preventing late stent thrombosis. We propose a novel method for targeted delivery of stem cells to a site of arterial injury using ultrasound-generated acoustic radiation force. Mesenchymal stem cells (MSCs) were surface-coated electrostatically with cationic gas-filled lipid microbubbles (mb-MSC). mb-MSC was characterized microscopically and by flow cytometry. The effect of ultrasound (5 MHz) on directing mb-MSC movement toward the vessel wall under physiologic flow conditions was tested in vitro in a vessel phantom. In vivo testing of acoustic radiation force-mediated delivery of mb-MSCs to balloon-injured aorta was performed in rabbits using intravascular ultrasound (1.7 MHz) during intra-aortic infusion of mb-MSCs. Application of ultrasound led to marginalization and adhesion of mb-MSCs to the vessel phantom wall, whereas no effect was observed on mb-MSCs in the absence of ultrasound. The effect was maximal when there were 7±1 microbubbles/cell (n=6). In rabbits (n=6), adherent MSCs were observed in the ultrasound-treated aortic segment 20 min after the injection (334±137 MSCs/cm(2)), whereas minimal adhesion was observed in control segments not exposed to ultrasound (2±1 MSCs/cm(2), p<0.05). At 24 h after mb-MSC injection and ultrasound treatment, the engrafted MSCs persisted and spread out on the luminal surface of the artery. The data demonstrate proof of principle that acoustic radiation force can target delivery of therapeutic cells to a specific endovascular treatment site. This approach may be used for endoluminal cellular paving and could provide a powerful tool for cell-based re-endothelialization of injured arterial segments." @default.
• W2015654015 created "2016-06-24" @default.
• W2015654015 creator A5005790287 @default.
• W2015654015 creator A5020075785 @default.
• W2015654015 creator A5028485276 @default.
• W2015654015 creator A5034024284 @default.
• W2015654015 creator A5034957689 @default.
• W2015654015 creator A5038506540 @default.
• W2015654015 creator A5045386624 @default.
• W2015654015 creator A5055020670 @default.
• W2015654015 creator A5057301071 @default.
• W2015654015 creator A5077353591 @default.
• W2015654015 creator A5077714526 @default.
• W2015654015 creator A5081374337 @default.
• W2015654015 creator A5081571713 @default.
• W2015654015 date "2011-05-01" @default.
• W2015654015 modified "2023-10-14" @default.
• W2015654015 title "Vascular Endoluminal Delivery of Mesenchymal Stem Cells Using Acoustic Radiation Force" @default.
• W2015654015 cites W1965539044 @default.
• W2015654015 cites W1995344483 @default.
• W2015654015 cites W1998476547 @default.
• W2015654015 cites W2003996125 @default.
• W2015654015 cites W2015230404 @default.
• W2015654015 cites W2025215537 @default.
• W2015654015 cites W2031485366 @default.
• W2015654015 cites W2044991253 @default.
• W2015654015 cites W2060648309 @default.
• W2015654015 cites W2061556888 @default.
• W2015654015 cites W207673420 @default.
• W2015654015 cites W2081956075 @default.
• W2015654015 cites W2091209385 @default.
• W2015654015 cites W2092566704 @default.
• W2015654015 cites W2114222046 @default.
• W2015654015 cites W2119470649 @default.
• W2015654015 cites W2119947454 @default.
• W2015654015 cites W2123957603 @default.
• W2015654015 cites W2133164437 @default.
• W2015654015 cites W2138946470 @default.
• W2015654015 cites W2144577699 @default.
• W2015654015 cites W2145901145 @default.
• W2015654015 cites W2148024435 @default.
• W2015654015 cites W2328852314 @default.
• W2015654015 doi "https://doi.org/10.1089/ten.tea.2010.0539" @default.
• W2015654015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3079165" @default.
• W2015654015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21247343" @default.
• W2015654015 hasPublicationYear "2011" @default.
• W2015654015 type Work @default.
• W2015654015 sameAs 2015654015 @default.
• W2015654015 citedByCount "29" @default.
• W2015654015 countsByYear W20156540152012 @default.
• W2015654015 countsByYear W20156540152013 @default.
• W2015654015 countsByYear W20156540152014 @default.
• W2015654015 countsByYear W20156540152015 @default.
• W2015654015 countsByYear W20156540152016 @default.
• W2015654015 countsByYear W20156540152017 @default.
• W2015654015 countsByYear W20156540152018 @default.
• W2015654015 countsByYear W20156540152019 @default.
• W2015654015 countsByYear W20156540152021 @default.
• W2015654015 countsByYear W20156540152022 @default.
• W2015654015 countsByYear W20156540152023 @default.
• W2015654015 crossrefType "journal-article" @default.
• W2015654015 hasAuthorship W2015654015A5005790287 @default.
• W2015654015 hasAuthorship W2015654015A5020075785 @default.
• W2015654015 hasAuthorship W2015654015A5028485276 @default.
• W2015654015 hasAuthorship W2015654015A5034024284 @default.
• W2015654015 hasAuthorship W2015654015A5034957689 @default.
• W2015654015 hasAuthorship W2015654015A5038506540 @default.
• W2015654015 hasAuthorship W2015654015A5045386624 @default.
• W2015654015 hasAuthorship W2015654015A5055020670 @default.
• W2015654015 hasAuthorship W2015654015A5057301071 @default.
• W2015654015 hasAuthorship W2015654015A5077353591 @default.
• W2015654015 hasAuthorship W2015654015A5077714526 @default.
• W2015654015 hasAuthorship W2015654015A5081374337 @default.
• W2015654015 hasAuthorship W2015654015A5081571713 @default.
• W2015654015 hasBestOaLocation W20156540152 @default.
• W2015654015 hasConcept C104293457 @default.
• W2015654015 hasConcept C126838900 @default.
• W2015654015 hasConcept C136229726 @default.
• W2015654015 hasConcept C142724271 @default.
• W2015654015 hasConcept C143753070 @default.
• W2015654015 hasConcept C150903083 @default.
• W2015654015 hasConcept C198826908 @default.
• W2015654015 hasConcept C207001950 @default.
• W2015654015 hasConcept C2781325599 @default.
• W2015654015 hasConcept C64012434 @default.
• W2015654015 hasConcept C71924100 @default.
• W2015654015 hasConcept C86803240 @default.
• W2015654015 hasConceptScore W2015654015C104293457 @default.
• W2015654015 hasConceptScore W2015654015C126838900 @default.
• W2015654015 hasConceptScore W2015654015C136229726 @default.
• W2015654015 hasConceptScore W2015654015C142724271 @default.
• W2015654015 hasConceptScore W2015654015C143753070 @default.
• W2015654015 hasConceptScore W2015654015C150903083 @default.
• W2015654015 hasConceptScore W2015654015C198826908 @default.
• W2015654015 hasConceptScore W2015654015C207001950 @default.
• W2015654015 hasConceptScore W2015654015C2781325599 @default.
• W2015654015 hasConceptScore W2015654015C64012434 @default.
• W2015654015 hasConceptScore W2015654015C71924100 @default.

• next