FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015659076> ?p ?o ?g. }

• W2015659076 endingPage "10" @default.
• W2015659076 startingPage "5" @default.
• W2015659076 abstract "Objective There are few validated relapse prediction biomarkers for epithelial ovarian cancer (EOC). We have shown progranulin (PGRN) and secretory leukocyte protease inhibitor (SLPI) are up regulated, overexpressed survival factors in EOC. We hypothesized they would predict presence of occult EOC. Method PGRN, SLPI, and the known biomarker HE4 were measured in EOC patient plasma samples, prospectively collected every 3 months from initial remission until relapse. Clinical data and CA125 results were incorporated into statistical analyses. Exploratory Kaplan–Meier estimates, dividing markers at median values, evaluated association with progression-free survival (PFS) and overall survival (OS). Area-under-the-curve (AUC) statistics were computed from receiver operating characteristic (ROC) curves to evaluate discrimination ability. A Cox proportional hazards model assessed the association between PFS, OS, and biomarkers, adjusting for clinical prognostic factors. Results Samples from 23 advanced stage EOC patients were evaluated. PGRN at 3 months was the only biomarker independently associated with PFS (P<0.0001) and OS (P<0.003). When used to predict progression by 18 months, sensitivity and specificity were 93% and 100%, respectively, with AUC=0.944. The Cox model hazard ratio for PFS, divided at 59 ng/ml by ROC analysis and adjusted for clinical factors, was 23.5 (95% CI: 2.49–220). Combinations with SLPI, HE4, and/or CA125 did not improve the model. Conclusions We report pilot data indicating a potential independent association of PGRN on EOC patient PFS and OS. A validation study will be required to confirm this finding and to inform whether PGRN warrants evaluation as a potential screening biomarker." @default.
• W2015659076 created "2016-06-24" @default.
• W2015659076 creator A5005621340 @default.
• W2015659076 creator A5017631832 @default.
• W2015659076 creator A5044239219 @default.
• W2015659076 creator A5059967384 @default.
• W2015659076 creator A5080434743 @default.
• W2015659076 date "2011-01-01" @default.
• W2015659076 modified "2023-09-22" @default.
• W2015659076 title "Progranulin is a potential prognostic biomarker in advanced epithelial ovarian cancers" @default.
• W2015659076 cites W1964265994 @default.
• W2015659076 cites W1966726942 @default.
• W2015659076 cites W1991770526 @default.
• W2015659076 cites W2020719670 @default.
• W2015659076 cites W2023428079 @default.
• W2015659076 cites W2038115045 @default.
• W2015659076 cites W2038328856 @default.
• W2015659076 cites W2046700952 @default.
• W2015659076 cites W2054553540 @default.
• W2015659076 cites W2075493427 @default.
• W2015659076 cites W2076140261 @default.
• W2015659076 cites W2087157867 @default.
• W2015659076 cites W2092068698 @default.
• W2015659076 cites W2093252833 @default.
• W2015659076 cites W2094933428 @default.
• W2015659076 cites W2095129820 @default.
• W2015659076 cites W2095973840 @default.
• W2015659076 cites W2100029286 @default.
• W2015659076 cites W2101995865 @default.
• W2015659076 cites W2127477679 @default.
• W2015659076 cites W2141115416 @default.
• W2015659076 cites W2148495545 @default.
• W2015659076 cites W2152107283 @default.
• W2015659076 cites W2162779707 @default.
• W2015659076 cites W2165628351 @default.
• W2015659076 cites W2166310305 @default.
• W2015659076 cites W2167006237 @default.
• W2015659076 cites W2167649358 @default.
• W2015659076 cites W2168803496 @default.
• W2015659076 cites W2590143643 @default.
• W2015659076 doi "https://doi.org/10.1016/j.ygyno.2010.09.006" @default.
• W2015659076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2997933" @default.
• W2015659076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20950846" @default.
• W2015659076 hasPublicationYear "2011" @default.
• W2015659076 type Work @default.
• W2015659076 sameAs 2015659076 @default.
• W2015659076 citedByCount "52" @default.
• W2015659076 countsByYear W20156590762012 @default.
• W2015659076 countsByYear W20156590762013 @default.
• W2015659076 countsByYear W20156590762014 @default.
• W2015659076 countsByYear W20156590762015 @default.
• W2015659076 countsByYear W20156590762016 @default.
• W2015659076 countsByYear W20156590762017 @default.
• W2015659076 countsByYear W20156590762018 @default.
• W2015659076 countsByYear W20156590762019 @default.
• W2015659076 countsByYear W20156590762020 @default.
• W2015659076 countsByYear W20156590762021 @default.
• W2015659076 countsByYear W20156590762022 @default.
• W2015659076 countsByYear W20156590762023 @default.
• W2015659076 crossrefType "journal-article" @default.
• W2015659076 hasAuthorship W2015659076A5005621340 @default.
• W2015659076 hasAuthorship W2015659076A5017631832 @default.
• W2015659076 hasAuthorship W2015659076A5044239219 @default.
• W2015659076 hasAuthorship W2015659076A5059967384 @default.
• W2015659076 hasAuthorship W2015659076A5080434743 @default.
• W2015659076 hasBestOaLocation W20156590762 @default.
• W2015659076 hasConcept C121608353 @default.
• W2015659076 hasConcept C126322002 @default.
• W2015659076 hasConcept C143998085 @default.
• W2015659076 hasConcept C146357865 @default.
• W2015659076 hasConcept C151730666 @default.
• W2015659076 hasConcept C185592680 @default.
• W2015659076 hasConcept C207103383 @default.
• W2015659076 hasConcept C2780427987 @default.
• W2015659076 hasConcept C2781197716 @default.
• W2015659076 hasConcept C2992773878 @default.
• W2015659076 hasConcept C44249647 @default.
• W2015659076 hasConcept C50382708 @default.
• W2015659076 hasConcept C55493867 @default.
• W2015659076 hasConcept C58471807 @default.
• W2015659076 hasConcept C71924100 @default.
• W2015659076 hasConcept C86803240 @default.
• W2015659076 hasConceptScore W2015659076C121608353 @default.
• W2015659076 hasConceptScore W2015659076C126322002 @default.
• W2015659076 hasConceptScore W2015659076C143998085 @default.
• W2015659076 hasConceptScore W2015659076C146357865 @default.
• W2015659076 hasConceptScore W2015659076C151730666 @default.
• W2015659076 hasConceptScore W2015659076C185592680 @default.
• W2015659076 hasConceptScore W2015659076C207103383 @default.
• W2015659076 hasConceptScore W2015659076C2780427987 @default.
• W2015659076 hasConceptScore W2015659076C2781197716 @default.
• W2015659076 hasConceptScore W2015659076C2992773878 @default.
• W2015659076 hasConceptScore W2015659076C44249647 @default.
• W2015659076 hasConceptScore W2015659076C50382708 @default.
• W2015659076 hasConceptScore W2015659076C55493867 @default.
• W2015659076 hasConceptScore W2015659076C58471807 @default.
• W2015659076 hasConceptScore W2015659076C71924100 @default.
• W2015659076 hasConceptScore W2015659076C86803240 @default.

• next