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• W2015662032 abstract "Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis. We have previously shown that homocysteine can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes in vitro. In the present study, we investigated whether redox factor-1 (Ref-1) is involved in HHcy-accelerated atherosclerosis. We used a mild HHcy animal model, aortic roots and peritoneal macrophages were isolated for immunohistochemistry and Western blotting, from apoE−/− and C57BL/6J mice fed a high Hcy diet (1.8 g/L) for 4 or 12 weeks. Four-week HHcy apoE−/− mice showed more plaques and significantly increased immunostaining of Ref-1 and MCP-1 in foam cells, and HHcy mice showed enhanced Ref-1 expression in peritoneal macrophages. To explore the mediating mechanism, incubation with Hcy (100 μM) increased Ref-1 protein level and translocation in human monocytes in vitro. In addition, Hcy-induced NADPH oxidase activity mediated the upregulation of Ref-1. Furthermore, overexpressed Ref-1 upregulated NF-κB and MCP-1 promoter activity, and antisense Ref-1 reduced Hcy-induced NF-κB DNA-binding activity and MCP-1 secretion. These data indicate that Hcy-induced ROS upregulate the expression and translocation of Ref-1 via NADPH oxidase, and then Ref-1 increases NF-κB activity and MCP-1 secretion in human monocytes/macrophages, which may accelerate the development of atherosclerosis." @default.
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• W2015662032 date "2006-11-01" @default.
• W2015662032 modified "2023-10-16" @default.
• W2015662032 title "Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis" @default.
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• W2015662032 doi "https://doi.org/10.1016/j.freeradbiomed.2006.08.020" @default.
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