FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015663762> ?p ?o ?g. }

• W2015663762 endingPage "3968" @default.
• W2015663762 startingPage "3958" @default.
• W2015663762 abstract "Influenza is a common and highly contagious viral pathogen, yet its effects on the structure and function of the CNS remain largely unknown. Although there is evidence that influenza strains that infect the brain can lead to altered cognitive and emotional behaviors, it is unknown whether a viral strain that is not neurotropic (A/PR/8/34) can result in a central inflammatory response, neuronal damage, and neurobehavioral effects. We hypothesized that neuroinflammation and alterations in hippocampal neuron morphology may parallel cognitive dysfunction following peripheral infection with live influenza virus. Here, we show that influenza-infected mice exhibited cognitive deficits in a reversal learning version of the Morris water maze. At the same time point in which cognitive impairment was evident, proinflammatory cytokines (IL-1β, IL-6, TNF-α, IFN-α) and microglial reactivity were increased, while neurotrophic (BDNF, NGF) and immunomodulatory (CD200, CX3CL1) factors were decreased in the hippocampus of infected mice. In addition, influenza induced architectural changes to hippocampal neurons in the CA1 and dentate gyrus, with the most profound effects on dentate granule cells in the innermost portion of the granule cell layer. Overall, these data provide the first evidence that neuroinflammation and changes in hippocampal structural plasticity may underlie cognitive dysfunction associated with influenza infection. In addition, the heightened inflammatory state concurrent with reduced neurotrophic support could leave the brain vulnerable to subsequent insult following influenza infection. A better understanding of how influenza impacts the brain and behavior may provide insight for preventing inflammation and neuronal damage during peripheral viral infection." @default.
• W2015663762 created "2016-06-24" @default.
• W2015663762 creator A5012476537 @default.
• W2015663762 creator A5038827888 @default.
• W2015663762 creator A5049285623 @default.
• W2015663762 date "2012-03-21" @default.
• W2015663762 modified "2023-10-10" @default.
• W2015663762 title "Influenza Infection Induces Neuroinflammation, Alters Hippocampal Neuron Morphology, and Impairs Cognition in Adult Mice" @default.
• W2015663762 cites W1553210510 @default.
• W2015663762 cites W1585088309 @default.
• W2015663762 cites W1792389655 @default.
• W2015663762 cites W1956591954 @default.
• W2015663762 cites W1962355416 @default.
• W2015663762 cites W1962474939 @default.
• W2015663762 cites W1964041350 @default.
• W2015663762 cites W1966810593 @default.
• W2015663762 cites W1967061503 @default.
• W2015663762 cites W1971681588 @default.
• W2015663762 cites W1983226940 @default.
• W2015663762 cites W1984854704 @default.
• W2015663762 cites W1988016557 @default.
• W2015663762 cites W1989369404 @default.
• W2015663762 cites W1990596248 @default.
• W2015663762 cites W1994580609 @default.
• W2015663762 cites W1999419270 @default.
• W2015663762 cites W2002734542 @default.
• W2015663762 cites W2002963207 @default.
• W2015663762 cites W2002980831 @default.
• W2015663762 cites W2003123811 @default.
• W2015663762 cites W2003665687 @default.
• W2015663762 cites W2003674452 @default.
• W2015663762 cites W2004349171 @default.
• W2015663762 cites W2008329588 @default.
• W2015663762 cites W2011672325 @default.
• W2015663762 cites W2012423618 @default.
• W2015663762 cites W2015851283 @default.
• W2015663762 cites W2016153276 @default.
• W2015663762 cites W2027464472 @default.
• W2015663762 cites W2029341006 @default.
• W2015663762 cites W2029906813 @default.
• W2015663762 cites W2032928022 @default.
• W2015663762 cites W2036091553 @default.
• W2015663762 cites W2036956824 @default.
• W2015663762 cites W2039242833 @default.
• W2015663762 cites W2041796079 @default.
• W2015663762 cites W2042551985 @default.
• W2015663762 cites W2045392948 @default.
• W2015663762 cites W2045864910 @default.
• W2015663762 cites W2050186422 @default.
• W2015663762 cites W2053176712 @default.
• W2015663762 cites W2054594878 @default.
• W2015663762 cites W2059256003 @default.
• W2015663762 cites W2059310590 @default.
• W2015663762 cites W2063139961 @default.
• W2015663762 cites W2064815909 @default.
• W2015663762 cites W2066809700 @default.
• W2015663762 cites W2068402255 @default.
• W2015663762 cites W2069465895 @default.
• W2015663762 cites W2073170210 @default.
• W2015663762 cites W2073234751 @default.
• W2015663762 cites W2078343139 @default.
• W2015663762 cites W2083340656 @default.
• W2015663762 cites W2087146795 @default.
• W2015663762 cites W2087771052 @default.
• W2015663762 cites W2088185033 @default.
• W2015663762 cites W2094544368 @default.
• W2015663762 cites W2094660330 @default.
• W2015663762 cites W2095547457 @default.
• W2015663762 cites W2099347739 @default.
• W2015663762 cites W2104730345 @default.
• W2015663762 cites W2109759840 @default.
• W2015663762 cites W2110887671 @default.
• W2015663762 cites W2111004700 @default.
• W2015663762 cites W2112880160 @default.
• W2015663762 cites W2113107925 @default.
• W2015663762 cites W2113359046 @default.
• W2015663762 cites W2114570899 @default.
• W2015663762 cites W2121782636 @default.
• W2015663762 cites W2126795224 @default.
• W2015663762 cites W2128752949 @default.
• W2015663762 cites W2137220106 @default.
• W2015663762 cites W2145709603 @default.
• W2015663762 cites W2149223457 @default.
• W2015663762 cites W2154849519 @default.
• W2015663762 cites W2157353633 @default.
• W2015663762 cites W2158506678 @default.
• W2015663762 cites W2159744102 @default.
• W2015663762 cites W2159984141 @default.
• W2015663762 cites W2164815751 @default.
• W2015663762 cites W2168610467 @default.
• W2015663762 cites W2169473035 @default.
• W2015663762 cites W2294869278 @default.
• W2015663762 cites W76162558 @default.
• W2015663762 doi "https://doi.org/10.1523/jneurosci.6389-11.2012" @default.
• W2015663762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3353809" @default.
• W2015663762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22442063" @default.
• W2015663762 hasPublicationYear "2012" @default.
• W2015663762 type Work @default.

• next