FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015663834> ?p ?o ?g. }

• W2015663834 endingPage "64" @default.
• W2015663834 startingPage "55" @default.
• W2015663834 abstract "The potent bacterial mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]- furanone) (MX), which is formed during chlorination of drinking water and accounts for about one third of the Ames mutagenicity of tap water, has been studied with respect to its genotoxicity in vitro and in vivo. Treatment with 30-300 microM MX (1 h) induced DNA damage in a concentration-dependent manner in suspensions of rat hepatocytes, as measured by an automated alkaline elution system. The effect was similar in hepatocytes from PCB-induced and uninduced rats. DNA damage was induced in V79 Chinese hamster cells and in isolated rat testicular cells, at the same concentration level as in hepatocytes. Pretreating testicular cells with diethylmaleate, which depletes 85% of cellular glutathione, had no significant effect on the DNA damage induced by MX. The treatment conditions used in the alkaline elution experiments were not cytotoxic to any of the cell types used, as determined by trypan blue exclusion. V79 cells exposed to 2-5 microM MX (2 h) showed an increased frequency of sister-chromatid exchanges (SCE) whereas no significant effect on HGPRT mutation induction was observed. Higher concentrations (greater than 10 microM, 2 h) apparently blocked cell division. The data indicate that MX can react directly with DNA or that MX is metabolized to an ultimate mutagen via some enzyme which is common in mammalian cells. The in vivo experiments showed no evidence of genotoxicity after intraperitoneal (18 mg/kg, 1 h) or oral (18, 63 or 125 mg/kg, 1 h) administration of MX, as measured by alkaline elution, in any of the following organs: the pyloric part of the stomach, the duodenum, colon ascendens, liver, kidney, lung, bone marrow, urinary bladder and the testes. In conclusion, MX is a direct-acting genotoxicant in vitro but no in vivo genotoxicity was detected." @default.
• W2015663834 created "2016-06-24" @default.
• W2015663834 creator A5011676965 @default.
• W2015663834 creator A5014466291 @default.
• W2015663834 creator A5046745340 @default.
• W2015663834 creator A5056877683 @default.
• W2015663834 creator A5066023889 @default.
• W2015663834 creator A5070817334 @default.
• W2015663834 creator A5090704530 @default.
• W2015663834 date "1991-05-01" @default.
• W2015663834 modified "2023-10-16" @default.
• W2015663834 title "Genotoxic effects of the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) in mammalian cells in vitro and in rats in vivo" @default.
• W2015663834 cites W1490154674 @default.
• W2015663834 cites W1970760230 @default.
• W2015663834 cites W1977327746 @default.
• W2015663834 cites W1985214527 @default.
• W2015663834 cites W1992113844 @default.
• W2015663834 cites W2002174532 @default.
• W2015663834 cites W2002335651 @default.
• W2015663834 cites W2018452213 @default.
• W2015663834 cites W2025723655 @default.
• W2015663834 cites W2026991016 @default.
• W2015663834 cites W2033800046 @default.
• W2015663834 cites W2035760808 @default.
• W2015663834 cites W2051591343 @default.
• W2015663834 cites W2073021146 @default.
• W2015663834 cites W2077303224 @default.
• W2015663834 cites W2078564648 @default.
• W2015663834 cites W2081540562 @default.
• W2015663834 cites W2084261443 @default.
• W2015663834 cites W2088150569 @default.
• W2015663834 cites W2092080967 @default.
• W2015663834 cites W2343724130 @default.
• W2015663834 cites W4292230194 @default.
• W2015663834 doi "https://doi.org/10.1016/0165-1218(91)90080-6" @default.
• W2015663834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1902909" @default.
• W2015663834 hasPublicationYear "1991" @default.
• W2015663834 type Work @default.
• W2015663834 sameAs 2015663834 @default.
• W2015663834 citedByCount "70" @default.
• W2015663834 countsByYear W20156638342012 @default.
• W2015663834 countsByYear W20156638342018 @default.
• W2015663834 countsByYear W20156638342019 @default.
• W2015663834 countsByYear W20156638342020 @default.
• W2015663834 crossrefType "journal-article" @default.
• W2015663834 hasAuthorship W2015663834A5011676965 @default.
• W2015663834 hasAuthorship W2015663834A5014466291 @default.
• W2015663834 hasAuthorship W2015663834A5046745340 @default.
• W2015663834 hasAuthorship W2015663834A5056877683 @default.
• W2015663834 hasAuthorship W2015663834A5066023889 @default.
• W2015663834 hasAuthorship W2015663834A5070817334 @default.
• W2015663834 hasAuthorship W2015663834A5090704530 @default.
• W2015663834 hasConcept C117632636 @default.
• W2015663834 hasConcept C143425029 @default.
• W2015663834 hasConcept C153911025 @default.
• W2015663834 hasConcept C178790620 @default.
• W2015663834 hasConcept C181199279 @default.
• W2015663834 hasConcept C185592680 @default.
• W2015663834 hasConcept C202751555 @default.
• W2015663834 hasConcept C207001950 @default.
• W2015663834 hasConcept C2776200302 @default.
• W2015663834 hasConcept C2776639595 @default.
• W2015663834 hasConcept C2777755551 @default.
• W2015663834 hasConcept C2778575167 @default.
• W2015663834 hasConcept C2778959862 @default.
• W2015663834 hasConcept C2779071816 @default.
• W2015663834 hasConcept C2780070996 @default.
• W2015663834 hasConcept C2781065037 @default.
• W2015663834 hasConcept C2781422964 @default.
• W2015663834 hasConcept C29730261 @default.
• W2015663834 hasConcept C523546767 @default.
• W2015663834 hasConcept C538909803 @default.
• W2015663834 hasConcept C54355233 @default.
• W2015663834 hasConcept C552990157 @default.
• W2015663834 hasConcept C55493867 @default.
• W2015663834 hasConcept C86803240 @default.
• W2015663834 hasConceptScore W2015663834C117632636 @default.
• W2015663834 hasConceptScore W2015663834C143425029 @default.
• W2015663834 hasConceptScore W2015663834C153911025 @default.
• W2015663834 hasConceptScore W2015663834C178790620 @default.
• W2015663834 hasConceptScore W2015663834C181199279 @default.
• W2015663834 hasConceptScore W2015663834C185592680 @default.
• W2015663834 hasConceptScore W2015663834C202751555 @default.
• W2015663834 hasConceptScore W2015663834C207001950 @default.
• W2015663834 hasConceptScore W2015663834C2776200302 @default.
• W2015663834 hasConceptScore W2015663834C2776639595 @default.
• W2015663834 hasConceptScore W2015663834C2777755551 @default.
• W2015663834 hasConceptScore W2015663834C2778575167 @default.
• W2015663834 hasConceptScore W2015663834C2778959862 @default.
• W2015663834 hasConceptScore W2015663834C2779071816 @default.
• W2015663834 hasConceptScore W2015663834C2780070996 @default.
• W2015663834 hasConceptScore W2015663834C2781065037 @default.
• W2015663834 hasConceptScore W2015663834C2781422964 @default.
• W2015663834 hasConceptScore W2015663834C29730261 @default.
• W2015663834 hasConceptScore W2015663834C523546767 @default.
• W2015663834 hasConceptScore W2015663834C538909803 @default.
• W2015663834 hasConceptScore W2015663834C54355233 @default.
• W2015663834 hasConceptScore W2015663834C552990157 @default.

• next