Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015665763> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2015665763 endingPage "190" @default.
- W2015665763 startingPage "187" @default.
- W2015665763 abstract "Neurological improvement in braintumor patients treated with dexamethasone (DEX) precedes a reduction in peritumor brain edema. In the study reported here, levels of noradrenaline (NA), dopamine (DA) and 5-hydroxytryptamine (5-HT), homovanillic acid (HVA) and 5-hydroxyindole-3-acetic acid (5-HIAA) and tissue water content were measured in grey and white matter adjacent to a 9L glioma in the cat to study DEX-neurotransmitter interactions as possible mechanisms for the acute neurological effects of DEX. Tumor-bearing and control cats were treated or not treated with DEX (0.25 mg/kg IV, 0.25 mg/kg IM) with 0.25 mg/kg IM repeated once (DEX 1) or 3 times (DEX 2) 6 hr apart. In control animals DEX 1 treatment led to significant decreases in concentration of DOPAC; DEX 2 treatment led to increases in HVA and 5-HIAA. Peritumor grey matter from untreated tumor-bearing animals had decreased levels of NA and DA and the metabolite DOPAC with no changes in 5-HT and 5-HIAA. DEX 2 but not DEX 1 resulted in a normalization (increase) in peritumor levels of DA and DOPAC. Neither dose of DEX reduced white matter edema. These findings suggest that the acute beneficial effect of DEX on neurological status may be due to alleviation of neurotransmitter amine and metabolite depletion." @default.
- W2015665763 created "2016-06-24" @default.
- W2015665763 creator A5060693324 @default.
- W2015665763 creator A5071218514 @default.
- W2015665763 creator A5088403251 @default.
- W2015665763 date "1989-02-01" @default.
- W2015665763 modified "2023-09-26" @default.
- W2015665763 title "Effect of dexamethasone on monoamine and metabolite levels in a brain-tumor model" @default.
- W2015665763 cites W144483470 @default.
- W2015665763 cites W1549940398 @default.
- W2015665763 cites W1999101268 @default.
- W2015665763 cites W2030659813 @default.
- W2015665763 cites W2031772071 @default.
- W2015665763 cites W2050667075 @default.
- W2015665763 cites W2053928188 @default.
- W2015665763 cites W2054212569 @default.
- W2015665763 cites W2078198452 @default.
- W2015665763 cites W2081922493 @default.
- W2015665763 cites W2083256719 @default.
- W2015665763 cites W2097912113 @default.
- W2015665763 cites W2139947638 @default.
- W2015665763 cites W2155574556 @default.
- W2015665763 cites W2288910275 @default.
- W2015665763 cites W2395802931 @default.
- W2015665763 cites W2406063163 @default.
- W2015665763 cites W2408069902 @default.
- W2015665763 cites W2885085881 @default.
- W2015665763 doi "https://doi.org/10.1016/0361-9230(89)90041-5" @default.
- W2015665763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2468398" @default.
- W2015665763 hasPublicationYear "1989" @default.
- W2015665763 type Work @default.
- W2015665763 sameAs 2015665763 @default.
- W2015665763 citedByCount "1" @default.
- W2015665763 crossrefType "journal-article" @default.
- W2015665763 hasAuthorship W2015665763A5060693324 @default.
- W2015665763 hasAuthorship W2015665763A5071218514 @default.
- W2015665763 hasAuthorship W2015665763A5088403251 @default.
- W2015665763 hasConcept C126322002 @default.
- W2015665763 hasConcept C126838900 @default.
- W2015665763 hasConcept C134018914 @default.
- W2015665763 hasConcept C143409427 @default.
- W2015665763 hasConcept C170493617 @default.
- W2015665763 hasConcept C185592680 @default.
- W2015665763 hasConcept C187714386 @default.
- W2015665763 hasConcept C2775841634 @default.
- W2015665763 hasConcept C2775864247 @default.
- W2015665763 hasConcept C2776219046 @default.
- W2015665763 hasConcept C2777477808 @default.
- W2015665763 hasConcept C2778013878 @default.
- W2015665763 hasConcept C2780401358 @default.
- W2015665763 hasConcept C2781192897 @default.
- W2015665763 hasConcept C513476851 @default.
- W2015665763 hasConcept C529278444 @default.
- W2015665763 hasConcept C71924100 @default.
- W2015665763 hasConcept C98274493 @default.
- W2015665763 hasConceptScore W2015665763C126322002 @default.
- W2015665763 hasConceptScore W2015665763C126838900 @default.
- W2015665763 hasConceptScore W2015665763C134018914 @default.
- W2015665763 hasConceptScore W2015665763C143409427 @default.
- W2015665763 hasConceptScore W2015665763C170493617 @default.
- W2015665763 hasConceptScore W2015665763C185592680 @default.
- W2015665763 hasConceptScore W2015665763C187714386 @default.
- W2015665763 hasConceptScore W2015665763C2775841634 @default.
- W2015665763 hasConceptScore W2015665763C2775864247 @default.
- W2015665763 hasConceptScore W2015665763C2776219046 @default.
- W2015665763 hasConceptScore W2015665763C2777477808 @default.
- W2015665763 hasConceptScore W2015665763C2778013878 @default.
- W2015665763 hasConceptScore W2015665763C2780401358 @default.
- W2015665763 hasConceptScore W2015665763C2781192897 @default.
- W2015665763 hasConceptScore W2015665763C513476851 @default.
- W2015665763 hasConceptScore W2015665763C529278444 @default.
- W2015665763 hasConceptScore W2015665763C71924100 @default.
- W2015665763 hasConceptScore W2015665763C98274493 @default.
- W2015665763 hasIssue "2" @default.
- W2015665763 hasLocation W20156657631 @default.
- W2015665763 hasLocation W20156657632 @default.
- W2015665763 hasOpenAccess W2015665763 @default.
- W2015665763 hasPrimaryLocation W20156657631 @default.
- W2015665763 hasRelatedWork W2013576534 @default.
- W2015665763 hasRelatedWork W2015665763 @default.
- W2015665763 hasRelatedWork W2018972664 @default.
- W2015665763 hasRelatedWork W2055262758 @default.
- W2015665763 hasRelatedWork W2064806863 @default.
- W2015665763 hasRelatedWork W2073440898 @default.
- W2015665763 hasRelatedWork W2112684472 @default.
- W2015665763 hasRelatedWork W2171454471 @default.
- W2015665763 hasRelatedWork W2341478320 @default.
- W2015665763 hasRelatedWork W2390113950 @default.
- W2015665763 hasVolume "22" @default.
- W2015665763 isParatext "false" @default.
- W2015665763 isRetracted "false" @default.
- W2015665763 magId "2015665763" @default.
- W2015665763 workType "article" @default.