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• W2015666721 abstract "Clinical Practice Points •Renal medullary carcinoma (RMC) is a rare and extremely aggressive tumor that is almost exclusively found in African American patients in the setting of sickle cell hemoglobinopathies. Most patients have evidence of metastatic disease at the time of presentation, with an average reported length of survival in various case reports is 15 weeks from the time of diagnosis. There currently is no standard of care for RMC, and the long-term responses to previously mentioned chemotherapy regimens such as MVAC (methotrexate, vinblastine, doxorubicin, and cisplatin) have largely been disappointing. •The new findings from our study include carboplatin and paclitaxel combination chemotherapy delivered at 3-week intervals, which demonstrated clinical response in both of our patients. One patient achieved partial radiologic resolution of disease, and the other patient had clinical stability of the disease, thus increasing the survival period. Our patients' postnephrectomy survival was approximately 11 and 15 months, respectively, which is comparable with the 16-month survival for high-dose-intensity MVAC and has exceeded that provided by other regimens, such as less-intense MVAC (12 months) or gemcitabine and paclitaxel (11 months). •Given the extremely aggressive nature and dismal prognosis of RMC, it is imperative that all possible avenues for treatment be investigated. Response of RMC to carboplatin and paclitaxel chemotherapy regimen supports the findings of effectiveness of this drug combination. It may provide a less toxic and more effective treatment option for this deadly malignancy in the setting of a currently limited pharmacologic armamentarium. •Renal medullary carcinoma (RMC) is a rare and extremely aggressive tumor that is almost exclusively found in African American patients in the setting of sickle cell hemoglobinopathies. Most patients have evidence of metastatic disease at the time of presentation, with an average reported length of survival in various case reports is 15 weeks from the time of diagnosis. There currently is no standard of care for RMC, and the long-term responses to previously mentioned chemotherapy regimens such as MVAC (methotrexate, vinblastine, doxorubicin, and cisplatin) have largely been disappointing. •The new findings from our study include carboplatin and paclitaxel combination chemotherapy delivered at 3-week intervals, which demonstrated clinical response in both of our patients. One patient achieved partial radiologic resolution of disease, and the other patient had clinical stability of the disease, thus increasing the survival period. Our patients' postnephrectomy survival was approximately 11 and 15 months, respectively, which is comparable with the 16-month survival for high-dose-intensity MVAC and has exceeded that provided by other regimens, such as less-intense MVAC (12 months) or gemcitabine and paclitaxel (11 months). •Given the extremely aggressive nature and dismal prognosis of RMC, it is imperative that all possible avenues for treatment be investigated. Response of RMC to carboplatin and paclitaxel chemotherapy regimen supports the findings of effectiveness of this drug combination. It may provide a less toxic and more effective treatment option for this deadly malignancy in the setting of a currently limited pharmacologic armamentarium." @default.
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• W2015666721 date "2012-06-01" @default.
• W2015666721 modified "2023-10-18" @default.
• W2015666721 title "Response of Metastatic Renal Medullary Carcinoma to Carboplatinum and Paclitaxel Chemotherapy" @default.
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• W2015666721 doi "https://doi.org/10.1016/j.clgc.2012.01.003" @default.
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