Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015668814> ?p ?o ?g. }
- W2015668814 endingPage "173" @default.
- W2015668814 startingPage "164" @default.
- W2015668814 abstract "Repeated low-dose morphine treatment facilitates delayed-escape behaviour of hippocampus-dependent Morris water maze and morphine withdrawal influences hippocampal NMDA receptor-dependent synaptic plasticity. Here, we examined whether and how morphine withdrawal influenced delayed-escape behaviour and NR2A/2B expression ratio of hippocampal synaptosomes. We found that both delayed-escape behaviour and NR2A/2B expression ratio showed an inverted-U curve and peaked on 4-day withdrawal during a 20-day withdrawal period. Furthermore, treatment of the glucocorticoid receptor antagonist RU38486 for 3 days reduced delayed-escape behaviour and NR2A/2B ratio on 4-day withdrawal to a level similar to those of 18-h withdrawal. In contrast, elevated-platform stress enabled delayed-escape behaviour of 18-h withdrawal to a higher level similar to that of 4-day withdrawal, but had no significant effect on the NR2A/2B ratio. Similar behavioural effects were also found after intrahippocampal infusions of the NMDAR antagonist AP-5 or NR2B-containing NMDAR antagonist Ro25-6981 for 3 days. These findings suggest that delayed-escape behaviour enabled by repeated low-dose morphine treatment may be a useful and simple rat model for studying addictive memories to be retrieved by stress exposure." @default.
- W2015668814 created "2016-06-24" @default.
- W2015668814 creator A5005520140 @default.
- W2015668814 creator A5009216477 @default.
- W2015668814 creator A5009267853 @default.
- W2015668814 creator A5017101764 @default.
- W2015668814 creator A5037102607 @default.
- W2015668814 creator A5046054643 @default.
- W2015668814 creator A5068417707 @default.
- W2015668814 creator A5071289091 @default.
- W2015668814 creator A5080465353 @default.
- W2015668814 creator A5086996757 @default.
- W2015668814 date "2008-05-01" @default.
- W2015668814 modified "2023-10-17" @default.
- W2015668814 title "Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio" @default.
- W2015668814 cites W1583309920 @default.
- W2015668814 cites W1709379088 @default.
- W2015668814 cites W1724698019 @default.
- W2015668814 cites W1948495312 @default.
- W2015668814 cites W1965875323 @default.
- W2015668814 cites W1968338376 @default.
- W2015668814 cites W1971110401 @default.
- W2015668814 cites W1982606706 @default.
- W2015668814 cites W1992704051 @default.
- W2015668814 cites W1998033984 @default.
- W2015668814 cites W2001567401 @default.
- W2015668814 cites W2006492271 @default.
- W2015668814 cites W2008301967 @default.
- W2015668814 cites W2009102686 @default.
- W2015668814 cites W2011275122 @default.
- W2015668814 cites W2017169966 @default.
- W2015668814 cites W2017392594 @default.
- W2015668814 cites W2021113234 @default.
- W2015668814 cites W2026986199 @default.
- W2015668814 cites W2028594041 @default.
- W2015668814 cites W2033505470 @default.
- W2015668814 cites W2047628284 @default.
- W2015668814 cites W2049253079 @default.
- W2015668814 cites W2049511526 @default.
- W2015668814 cites W2049796382 @default.
- W2015668814 cites W2059035573 @default.
- W2015668814 cites W2085155996 @default.
- W2015668814 cites W2088939071 @default.
- W2015668814 cites W2089525660 @default.
- W2015668814 cites W2090931660 @default.
- W2015668814 cites W2093005961 @default.
- W2015668814 cites W2104608731 @default.
- W2015668814 cites W2110724392 @default.
- W2015668814 cites W2112354679 @default.
- W2015668814 cites W2113734838 @default.
- W2015668814 cites W2113962949 @default.
- W2015668814 cites W2148389554 @default.
- W2015668814 cites W2151340091 @default.
- W2015668814 cites W2170298556 @default.
- W2015668814 cites W2171100953 @default.
- W2015668814 cites W2336514795 @default.
- W2015668814 cites W4247458622 @default.
- W2015668814 doi "https://doi.org/10.1016/j.brainres.2008.02.055" @default.
- W2015668814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18374314" @default.
- W2015668814 hasPublicationYear "2008" @default.
- W2015668814 type Work @default.
- W2015668814 sameAs 2015668814 @default.
- W2015668814 citedByCount "8" @default.
- W2015668814 countsByYear W20156688142013 @default.
- W2015668814 countsByYear W20156688142016 @default.
- W2015668814 countsByYear W20156688142018 @default.
- W2015668814 countsByYear W20156688142020 @default.
- W2015668814 countsByYear W20156688142022 @default.
- W2015668814 crossrefType "journal-article" @default.
- W2015668814 hasAuthorship W2015668814A5005520140 @default.
- W2015668814 hasAuthorship W2015668814A5009216477 @default.
- W2015668814 hasAuthorship W2015668814A5009267853 @default.
- W2015668814 hasAuthorship W2015668814A5017101764 @default.
- W2015668814 hasAuthorship W2015668814A5037102607 @default.
- W2015668814 hasAuthorship W2015668814A5046054643 @default.
- W2015668814 hasAuthorship W2015668814A5068417707 @default.
- W2015668814 hasAuthorship W2015668814A5071289091 @default.
- W2015668814 hasAuthorship W2015668814A5080465353 @default.
- W2015668814 hasAuthorship W2015668814A5086996757 @default.
- W2015668814 hasConcept C100691959 @default.
- W2015668814 hasConcept C126322002 @default.
- W2015668814 hasConcept C134018914 @default.
- W2015668814 hasConcept C148762608 @default.
- W2015668814 hasConcept C15744967 @default.
- W2015668814 hasConcept C169760540 @default.
- W2015668814 hasConcept C170493617 @default.
- W2015668814 hasConcept C24998067 @default.
- W2015668814 hasConcept C2776885963 @default.
- W2015668814 hasConcept C2777389121 @default.
- W2015668814 hasConcept C2780004078 @default.
- W2015668814 hasConcept C2780841215 @default.
- W2015668814 hasConcept C2781161787 @default.
- W2015668814 hasConcept C42219234 @default.
- W2015668814 hasConcept C59493245 @default.
- W2015668814 hasConcept C67018056 @default.
- W2015668814 hasConcept C71924100 @default.
- W2015668814 hasConceptScore W2015668814C100691959 @default.
- W2015668814 hasConceptScore W2015668814C126322002 @default.