Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015670742> ?p ?o ?g. }
- W2015670742 endingPage "717" @default.
- W2015670742 startingPage "705" @default.
- W2015670742 abstract "We previously described a dominant suppressor of the splicing defect conferred by an A→;C intron branchpoint mutation in S. cerevisiae. Suppression occurs by increasing the frequency with which the mutant branchpoint is utilized. We have now cloned the genomic region encoding the prp16-1 suppressor function and have demonstrated that PRP16 is essential for viability. A 1071 amino acid open reading frame contains sequence motifs characteristic of an NTP binding fold and further similarities to a superfamily of proteins that includes members with demonstrated RNA-dependent ATPase activity. A single nucleotide change necessary to confer the prp16-1 suppressor phenotype results in a Tyr→Asp substitution near the “A site” consensus for NTP binding proteins. We propose that PRP16 is an excellent candidate for mediating one of the many ATP-requiring steps of spliceosome assembly and that accuracy of branchpoint recognition may be coupled to ATP binding and/or hydrolysis." @default.
- W2015670742 created "2016-06-24" @default.
- W2015670742 creator A5027032925 @default.
- W2015670742 creator A5071683556 @default.
- W2015670742 creator A5090172616 @default.
- W2015670742 date "1990-03-01" @default.
- W2015670742 modified "2023-10-17" @default.
- W2015670742 title "A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing" @default.
- W2015670742 cites W1156525234 @default.
- W2015670742 cites W124504601 @default.
- W2015670742 cites W1486144458 @default.
- W2015670742 cites W1509448772 @default.
- W2015670742 cites W1524956043 @default.
- W2015670742 cites W1537782690 @default.
- W2015670742 cites W1559327258 @default.
- W2015670742 cites W1590852456 @default.
- W2015670742 cites W1644747357 @default.
- W2015670742 cites W172566245 @default.
- W2015670742 cites W1728967502 @default.
- W2015670742 cites W1832631296 @default.
- W2015670742 cites W1846763343 @default.
- W2015670742 cites W1852181705 @default.
- W2015670742 cites W1855498923 @default.
- W2015670742 cites W1883417851 @default.
- W2015670742 cites W1898875758 @default.
- W2015670742 cites W1903725617 @default.
- W2015670742 cites W1906716273 @default.
- W2015670742 cites W1968223204 @default.
- W2015670742 cites W1968276418 @default.
- W2015670742 cites W1969826188 @default.
- W2015670742 cites W1971478527 @default.
- W2015670742 cites W1975642325 @default.
- W2015670742 cites W1978020758 @default.
- W2015670742 cites W1979028741 @default.
- W2015670742 cites W1980424685 @default.
- W2015670742 cites W1981790879 @default.
- W2015670742 cites W1986121171 @default.
- W2015670742 cites W1995478437 @default.
- W2015670742 cites W1996690481 @default.
- W2015670742 cites W2000955810 @default.
- W2015670742 cites W2003213264 @default.
- W2015670742 cites W2003676968 @default.
- W2015670742 cites W2004140388 @default.
- W2015670742 cites W2012819319 @default.
- W2015670742 cites W2013836961 @default.
- W2015670742 cites W2014669590 @default.
- W2015670742 cites W2018455673 @default.
- W2015670742 cites W2024170620 @default.
- W2015670742 cites W2025873644 @default.
- W2015670742 cites W2029195137 @default.
- W2015670742 cites W2031332665 @default.
- W2015670742 cites W2043583718 @default.
- W2015670742 cites W2046074640 @default.
- W2015670742 cites W2059890422 @default.
- W2015670742 cites W2060578134 @default.
- W2015670742 cites W2061967064 @default.
- W2015670742 cites W2066157608 @default.
- W2015670742 cites W2069110490 @default.
- W2015670742 cites W2080119769 @default.
- W2015670742 cites W2081359387 @default.
- W2015670742 cites W2089796770 @default.
- W2015670742 cites W2091169894 @default.
- W2015670742 cites W2095450147 @default.
- W2015670742 cites W2099047634 @default.
- W2015670742 cites W2100179968 @default.
- W2015670742 cites W2110090133 @default.
- W2015670742 cites W2112590565 @default.
- W2015670742 cites W2113253034 @default.
- W2015670742 cites W2117708081 @default.
- W2015670742 cites W2122427014 @default.
- W2015670742 cites W2125434705 @default.
- W2015670742 cites W2125959590 @default.
- W2015670742 cites W2133687707 @default.
- W2015670742 cites W2150926871 @default.
- W2015670742 cites W2153033225 @default.
- W2015670742 cites W2157589212 @default.
- W2015670742 cites W2253075914 @default.
- W2015670742 cites W2621938426 @default.
- W2015670742 cites W280710876 @default.
- W2015670742 cites W4247079890 @default.
- W2015670742 cites W4254987404 @default.
- W2015670742 cites W89844765 @default.
- W2015670742 doi "https://doi.org/10.1016/0092-8674(90)90086-t" @default.
- W2015670742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2138057" @default.
- W2015670742 hasPublicationYear "1990" @default.
- W2015670742 type Work @default.
- W2015670742 sameAs 2015670742 @default.
- W2015670742 citedByCount "170" @default.
- W2015670742 countsByYear W20156707422012 @default.
- W2015670742 countsByYear W20156707422013 @default.
- W2015670742 countsByYear W20156707422014 @default.
- W2015670742 countsByYear W20156707422015 @default.
- W2015670742 countsByYear W20156707422016 @default.
- W2015670742 countsByYear W20156707422017 @default.
- W2015670742 countsByYear W20156707422019 @default.
- W2015670742 countsByYear W20156707422023 @default.
- W2015670742 crossrefType "journal-article" @default.
- W2015670742 hasAuthorship W2015670742A5027032925 @default.