FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015671306> ?p ?o ?g. }

• W2015671306 endingPage "576" @default.
• W2015671306 startingPage "571" @default.
• W2015671306 abstract "Tim-3 is a member of the TIM family of proteins (T-cell immunoglobulin mucin) involved in the regulation of CD4+ T-cells. Tim-3 is a T(H)1-specific type 1 membrane protein and regulates T(H)1 proliferation and the development of tolerance. Binding of galectin-9 to the extracellular domain of Tim-3 results in apoptosis of T(H)1 cells, but the intracellular pathways involved in the regulatory function of Tim-3 are unknown. Unlike Tim-1, which is expressed in renal epithelia and cancer, Tim-3 has not been described in cells other than neuronal or T-cells. Using RT-PCR we demonstrate that Tim-3 is expressed in malignant and non-malignant epithelial tissues. We have cloned Tim-3 from an immortalized liver cell carcinoma line and identified a highly conserved tyrosine in the intracellular tail of Tim-3 (Y265). We demonstrate that Y265 is specifically phosphorylated in vivo by the interleukin inducible T cell kinase (ITK), a kinase which is located in close proximity of the TIM genes on the allergy susceptibility locus 5q33.3. Stimulation of Tim-3 by its ligand galectin-9 results in increased phosphorylation of Y265, suggesting that this tyrosine residue plays an important role in downstream signalling events regulating T-cell fate. Given the role of TIM proteins in autoimmunity and cancer, the conserved SH2 binding domain surrounding Y265 could represent a possible target site for pharmacological intervention." @default.
• W2015671306 created "2016-06-24" @default.
• W2015671306 creator A5022895539 @default.
• W2015671306 creator A5024059133 @default.
• W2015671306 creator A5048410197 @default.
• W2015671306 creator A5053250157 @default.
• W2015671306 creator A5064203886 @default.
• W2015671306 creator A5089781525 @default.
• W2015671306 date "2006-12-01" @default.
• W2015671306 modified "2023-10-05" @default.
• W2015671306 title "A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9" @default.
• W2015671306 cites W1973879517 @default.
• W2015671306 cites W1983715014 @default.
• W2015671306 cites W1991701428 @default.
• W2015671306 cites W2012198462 @default.
• W2015671306 cites W2013177587 @default.
• W2015671306 cites W2021379322 @default.
• W2015671306 cites W2026271132 @default.
• W2015671306 cites W2028842451 @default.
• W2015671306 cites W2045421375 @default.
• W2015671306 cites W2046809698 @default.
• W2015671306 cites W2047062588 @default.
• W2015671306 cites W2065937821 @default.
• W2015671306 cites W2070631889 @default.
• W2015671306 cites W2071069822 @default.
• W2015671306 cites W2076724835 @default.
• W2015671306 cites W2080881682 @default.
• W2015671306 cites W2085678099 @default.
• W2015671306 cites W2087641723 @default.
• W2015671306 cites W2096840133 @default.
• W2015671306 cites W2099365070 @default.
• W2015671306 cites W2106584734 @default.
• W2015671306 cites W2114335223 @default.
• W2015671306 cites W2122828155 @default.
• W2015671306 cites W2128847715 @default.
• W2015671306 cites W2159436931 @default.
• W2015671306 cites W2164765860 @default.
• W2015671306 cites W2172223853 @default.
• W2015671306 doi "https://doi.org/10.1016/j.bbrc.2006.10.079" @default.
• W2015671306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17069754" @default.
• W2015671306 hasPublicationYear "2006" @default.
• W2015671306 type Work @default.
• W2015671306 sameAs 2015671306 @default.
• W2015671306 citedByCount "157" @default.
• W2015671306 countsByYear W20156713062012 @default.
• W2015671306 countsByYear W20156713062013 @default.
• W2015671306 countsByYear W20156713062014 @default.
• W2015671306 countsByYear W20156713062015 @default.
• W2015671306 countsByYear W20156713062016 @default.
• W2015671306 countsByYear W20156713062017 @default.
• W2015671306 countsByYear W20156713062018 @default.
• W2015671306 countsByYear W20156713062019 @default.
• W2015671306 countsByYear W20156713062020 @default.
• W2015671306 countsByYear W20156713062021 @default.
• W2015671306 countsByYear W20156713062022 @default.
• W2015671306 countsByYear W20156713062023 @default.
• W2015671306 crossrefType "journal-article" @default.
• W2015671306 hasAuthorship W2015671306A5022895539 @default.
• W2015671306 hasAuthorship W2015671306A5024059133 @default.
• W2015671306 hasAuthorship W2015671306A5048410197 @default.
• W2015671306 hasAuthorship W2015671306A5053250157 @default.
• W2015671306 hasAuthorship W2015671306A5064203886 @default.
• W2015671306 hasAuthorship W2015671306A5089781525 @default.
• W2015671306 hasConcept C11960822 @default.
• W2015671306 hasConcept C153911025 @default.
• W2015671306 hasConcept C156293190 @default.
• W2015671306 hasConcept C197153747 @default.
• W2015671306 hasConcept C2777553839 @default.
• W2015671306 hasConcept C42362537 @default.
• W2015671306 hasConcept C62478195 @default.
• W2015671306 hasConcept C86803240 @default.
• W2015671306 hasConcept C95444343 @default.
• W2015671306 hasConceptScore W2015671306C11960822 @default.
• W2015671306 hasConceptScore W2015671306C153911025 @default.
• W2015671306 hasConceptScore W2015671306C156293190 @default.
• W2015671306 hasConceptScore W2015671306C197153747 @default.
• W2015671306 hasConceptScore W2015671306C2777553839 @default.
• W2015671306 hasConceptScore W2015671306C42362537 @default.
• W2015671306 hasConceptScore W2015671306C62478195 @default.
• W2015671306 hasConceptScore W2015671306C86803240 @default.
• W2015671306 hasConceptScore W2015671306C95444343 @default.
• W2015671306 hasIssue "2" @default.
• W2015671306 hasLocation W20156713061 @default.
• W2015671306 hasLocation W20156713062 @default.
• W2015671306 hasOpenAccess W2015671306 @default.
• W2015671306 hasPrimaryLocation W20156713061 @default.
• W2015671306 hasRelatedWork W1969541617 @default.
• W2015671306 hasRelatedWork W2008858913 @default.
• W2015671306 hasRelatedWork W2020851933 @default.
• W2015671306 hasRelatedWork W2046901206 @default.
• W2015671306 hasRelatedWork W2096032969 @default.
• W2015671306 hasRelatedWork W2411955162 @default.
• W2015671306 hasRelatedWork W2412892123 @default.
• W2015671306 hasRelatedWork W2767338046 @default.
• W2015671306 hasRelatedWork W4244477508 @default.
• W2015671306 hasRelatedWork W4247927249 @default.
• W2015671306 hasVolume "351" @default.
• W2015671306 isParatext "false" @default.

• next