FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015674908> ?p ?o ?g. }

• W2015674908 endingPage "1225" @default.
• W2015674908 startingPage "1215" @default.
• W2015674908 abstract "Three-dimensional domain swapping occurs when two or more identical proteins exchange identical parts of their structure to generate an oligomeric unit. It affects proteins with diverse sequences and structures, and is expected to play important roles in evolution, functional regulation and even conformational diseases. Here, we search for traces of domain swapping in the protein sequence, by means of algorithms that predict the structure and stability of proteins using database-derived potentials. Regions whose sequences are not optimal with regard to the stability of the native structure, or showing marked intrinsic preferences for non-native conformations in absence of tertiary interactions are detected in most domain-swapping proteins. These regions are often located in areas crucial in the swapping process and are likely to influence it on a kinetic or thermodynamic level. In addition, cation–π interactions are frequently observed to zip up the edges of the interface between intertwined chains or to involve hinge loop residues, thereby modulating stability. We end by proposing a set of mutations altering the swapping propensities, whose experimental characterization would contribute to refine our in silico derived hypotheses." @default.
• W2015674908 created "2016-06-24" @default.
• W2015674908 creator A5037585501 @default.
• W2015674908 creator A5047671533 @default.
• W2015674908 creator A5068948301 @default.
• W2015674908 creator A5073330873 @default.
• W2015674908 creator A5091466337 @default.
• W2015674908 date "2003-07-01" @default.
• W2015674908 modified "2023-09-23" @default.
• W2015674908 title "Sequence-structure Signals of 3D Domain Swapping in Proteins" @default.
• W2015674908 cites W1485706583 @default.
• W2015674908 cites W1512596284 @default.
• W2015674908 cites W1553900867 @default.
• W2015674908 cites W1590313270 @default.
• W2015674908 cites W1591864042 @default.
• W2015674908 cites W174651672 @default.
• W2015674908 cites W1860073488 @default.
• W2015674908 cites W1965595310 @default.
• W2015674908 cites W1967770898 @default.
• W2015674908 cites W1969651682 @default.
• W2015674908 cites W1970232844 @default.
• W2015674908 cites W1973948008 @default.
• W2015674908 cites W1975425607 @default.
• W2015674908 cites W1978012062 @default.
• W2015674908 cites W1979602468 @default.
• W2015674908 cites W1996023910 @default.
• W2015674908 cites W2005914057 @default.
• W2015674908 cites W2017798666 @default.
• W2015674908 cites W2020542137 @default.
• W2015674908 cites W2023444769 @default.
• W2015674908 cites W2030045733 @default.
• W2015674908 cites W2030827815 @default.
• W2015674908 cites W2046829847 @default.
• W2015674908 cites W2054525948 @default.
• W2015674908 cites W2059907401 @default.
• W2015674908 cites W2061107874 @default.
• W2015674908 cites W2071148453 @default.
• W2015674908 cites W2077405765 @default.
• W2015674908 cites W2088776290 @default.
• W2015674908 cites W2090560276 @default.
• W2015674908 cites W2090799488 @default.
• W2015674908 cites W2103598875 @default.
• W2015674908 cites W2123564787 @default.
• W2015674908 cites W2130479394 @default.
• W2015674908 cites W2136447744 @default.
• W2015674908 cites W2148130200 @default.
• W2015674908 cites W2160082320 @default.
• W2015674908 cites W2171741848 @default.
• W2015674908 doi "https://doi.org/10.1016/s0022-2836(03)00614-4" @default.
• W2015674908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12860140" @default.
• W2015674908 hasPublicationYear "2003" @default.
• W2015674908 type Work @default.
• W2015674908 sameAs 2015674908 @default.
• W2015674908 citedByCount "45" @default.
• W2015674908 countsByYear W20156749082012 @default.
• W2015674908 countsByYear W20156749082013 @default.
• W2015674908 countsByYear W20156749082014 @default.
• W2015674908 countsByYear W20156749082015 @default.
• W2015674908 countsByYear W20156749082016 @default.
• W2015674908 countsByYear W20156749082017 @default.
• W2015674908 countsByYear W20156749082018 @default.
• W2015674908 countsByYear W20156749082019 @default.
• W2015674908 countsByYear W20156749082020 @default.
• W2015674908 countsByYear W20156749082021 @default.
• W2015674908 countsByYear W20156749082023 @default.
• W2015674908 crossrefType "journal-article" @default.
• W2015674908 hasAuthorship W2015674908A5037585501 @default.
• W2015674908 hasAuthorship W2015674908A5047671533 @default.
• W2015674908 hasAuthorship W2015674908A5068948301 @default.
• W2015674908 hasAuthorship W2015674908A5073330873 @default.
• W2015674908 hasAuthorship W2015674908A5091466337 @default.
• W2015674908 hasConcept C104317684 @default.
• W2015674908 hasConcept C112972136 @default.
• W2015674908 hasConcept C119857082 @default.
• W2015674908 hasConcept C134306372 @default.
• W2015674908 hasConcept C144292202 @default.
• W2015674908 hasConcept C177264268 @default.
• W2015674908 hasConcept C185592680 @default.
• W2015674908 hasConcept C186060115 @default.
• W2015674908 hasConcept C199360897 @default.
• W2015674908 hasConcept C2775905019 @default.
• W2015674908 hasConcept C2778112365 @default.
• W2015674908 hasConcept C2988375501 @default.
• W2015674908 hasConcept C33923547 @default.
• W2015674908 hasConcept C36503486 @default.
• W2015674908 hasConcept C41008148 @default.
• W2015674908 hasConcept C47701112 @default.
• W2015674908 hasConcept C54355233 @default.
• W2015674908 hasConcept C55493867 @default.
• W2015674908 hasConcept C70721500 @default.
• W2015674908 hasConcept C8010536 @default.
• W2015674908 hasConcept C86803240 @default.
• W2015674908 hasConceptScore W2015674908C104317684 @default.
• W2015674908 hasConceptScore W2015674908C112972136 @default.
• W2015674908 hasConceptScore W2015674908C119857082 @default.
• W2015674908 hasConceptScore W2015674908C134306372 @default.
• W2015674908 hasConceptScore W2015674908C144292202 @default.
• W2015674908 hasConceptScore W2015674908C177264268 @default.

• next