Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015675338> ?p ?o ?g. }
- W2015675338 endingPage "1118" @default.
- W2015675338 startingPage "1115" @default.
- W2015675338 abstract "The etiology of the autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's thyroiditis (HT) is largely unknown. However, genetic susceptibility is believed to play a major role. The lymphoid tyrosine phosphatase (LYP), encoded by the protein tyrosine phosphatase-22 (PTPN22) gene, is a powerful inhibitor of T cell activation. Recently, a single-nucleotide polymorphism (SNP), encoding a functional arginine to tryptophan residue change at PTPN22 codon 620 in Caucasians has been shown to be associated with GD and other autoimmune diseases. We have used a polymerase chain reaction (PCR)-restriction fragment (XcmI) assay to examine genotypes at the codon 620 polymorphism in 334 unrelated patients with AITD and 179 controls. None of the patients with AITD and controls had the tryptophan allele. These data suggest that the codon 620 polymorphism of the PTPN22 gene does not have a causal role for AITD in the Japanese. However, we cannot exclude the PTPN22 region as harboring another susceptibility locus for AITD in linkage disequilibrium with the Trp/Arg SNP." @default.
- W2015675338 created "2016-06-24" @default.
- W2015675338 creator A5025888553 @default.
- W2015675338 creator A5046505815 @default.
- W2015675338 creator A5050969203 @default.
- W2015675338 creator A5054721877 @default.
- W2015675338 creator A5066608887 @default.
- W2015675338 date "2005-10-01" @default.
- W2015675338 modified "2023-10-16" @default.
- W2015675338 title "The Codon 620 Single Nucleotide Polymorphism of the Protein Tyrosine Phosphatase-22 Gene Does not Contribute to Autoimmune Thyroid Disease Susceptibility in the Japanese" @default.
- W2015675338 cites W1519521580 @default.
- W2015675338 cites W1979482663 @default.
- W2015675338 cites W1981157461 @default.
- W2015675338 cites W1984273763 @default.
- W2015675338 cites W1984756348 @default.
- W2015675338 cites W1987677365 @default.
- W2015675338 cites W1990678679 @default.
- W2015675338 cites W1994402720 @default.
- W2015675338 cites W1998721237 @default.
- W2015675338 cites W2004419343 @default.
- W2015675338 cites W2008649874 @default.
- W2015675338 cites W2016193783 @default.
- W2015675338 cites W2022854964 @default.
- W2015675338 cites W2042076828 @default.
- W2015675338 cites W2046383867 @default.
- W2015675338 cites W2053382138 @default.
- W2015675338 cites W2068040418 @default.
- W2015675338 cites W2068982327 @default.
- W2015675338 cites W2070779422 @default.
- W2015675338 cites W2102872217 @default.
- W2015675338 cites W2103377785 @default.
- W2015675338 cites W2105243482 @default.
- W2015675338 cites W2124725638 @default.
- W2015675338 cites W2135167801 @default.
- W2015675338 cites W2138240417 @default.
- W2015675338 cites W2142155452 @default.
- W2015675338 cites W2142551674 @default.
- W2015675338 cites W2160847592 @default.
- W2015675338 cites W4243890801 @default.
- W2015675338 cites W4246260688 @default.
- W2015675338 cites W4252510257 @default.
- W2015675338 cites W4253786505 @default.
- W2015675338 cites W4361807026 @default.
- W2015675338 doi "https://doi.org/10.1089/thy.2005.15.1115" @default.
- W2015675338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16279843" @default.
- W2015675338 hasPublicationYear "2005" @default.
- W2015675338 type Work @default.
- W2015675338 sameAs 2015675338 @default.
- W2015675338 citedByCount "73" @default.
- W2015675338 countsByYear W20156753382012 @default.
- W2015675338 countsByYear W20156753382013 @default.
- W2015675338 countsByYear W20156753382014 @default.
- W2015675338 countsByYear W20156753382015 @default.
- W2015675338 countsByYear W20156753382016 @default.
- W2015675338 countsByYear W20156753382017 @default.
- W2015675338 countsByYear W20156753382018 @default.
- W2015675338 countsByYear W20156753382019 @default.
- W2015675338 countsByYear W20156753382020 @default.
- W2015675338 countsByYear W20156753382021 @default.
- W2015675338 countsByYear W20156753382022 @default.
- W2015675338 countsByYear W20156753382023 @default.
- W2015675338 crossrefType "journal-article" @default.
- W2015675338 hasAuthorship W2015675338A5025888553 @default.
- W2015675338 hasAuthorship W2015675338A5046505815 @default.
- W2015675338 hasAuthorship W2015675338A5050969203 @default.
- W2015675338 hasAuthorship W2015675338A5054721877 @default.
- W2015675338 hasAuthorship W2015675338A5066608887 @default.
- W2015675338 hasConcept C104317684 @default.
- W2015675338 hasConcept C11960822 @default.
- W2015675338 hasConcept C135763542 @default.
- W2015675338 hasConcept C153209595 @default.
- W2015675338 hasConcept C2779356809 @default.
- W2015675338 hasConcept C54355233 @default.
- W2015675338 hasConcept C85528070 @default.
- W2015675338 hasConcept C86803240 @default.
- W2015675338 hasConceptScore W2015675338C104317684 @default.
- W2015675338 hasConceptScore W2015675338C11960822 @default.
- W2015675338 hasConceptScore W2015675338C135763542 @default.
- W2015675338 hasConceptScore W2015675338C153209595 @default.
- W2015675338 hasConceptScore W2015675338C2779356809 @default.
- W2015675338 hasConceptScore W2015675338C54355233 @default.
- W2015675338 hasConceptScore W2015675338C85528070 @default.
- W2015675338 hasConceptScore W2015675338C86803240 @default.
- W2015675338 hasIssue "10" @default.
- W2015675338 hasLocation W20156753381 @default.
- W2015675338 hasLocation W20156753382 @default.
- W2015675338 hasOpenAccess W2015675338 @default.
- W2015675338 hasPrimaryLocation W20156753381 @default.
- W2015675338 hasRelatedWork W2002128513 @default.
- W2015675338 hasRelatedWork W2015700707 @default.
- W2015675338 hasRelatedWork W2155138739 @default.
- W2015675338 hasRelatedWork W2163417107 @default.
- W2015675338 hasRelatedWork W2325064685 @default.
- W2015675338 hasRelatedWork W2557087691 @default.
- W2015675338 hasRelatedWork W2612613273 @default.
- W2015675338 hasRelatedWork W2978396170 @default.
- W2015675338 hasRelatedWork W3135014740 @default.
- W2015675338 hasRelatedWork W2183907856 @default.