FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015678334> ?p ?o ?g. }

• W2015678334 endingPage "410" @default.
• W2015678334 startingPage "404" @default.
• W2015678334 abstract "Vaccine adjuvants stimulate the innate immune system and determine the outcome of the immune response induced. A better understanding of their action is therefore crucial to the development of new and safer vaccines. Monophosphoryl lipid A (MPL), a ‘detoxified’ version of lipolysaccharide, is a promising new adjuvant component in human vaccines. The present study uses an ovine lymphatic cannulation model to study cell recruitment and antigen transport from the injection site into the afferent lymph, and how this is modulated by co‐injection with MPL. Compared with saline, MPL injections caused only minor variations in lymph flow and no difference in cell number migrating into the lymph. MPL did, however, cause a significantly increased recruitment of neutrophils and monocytes, but not dendritic cells (DC) into the lymph for the first 12 h. Soluble ovalbumin (OVA) antigen flowed freely into the lymph over a 24‐h period and was slightly reduced at 6–9 h in the MPL‐injected sites. OVA‐coated fluorescent 1‐μ beads were initially transported predominantly by neutrophils and, from 24 to 72 h, by DC. MPL induced an increased and more sustained transport of beads by neutrophils and monocytes although it did not increase the phagocytic capacity of these cells. In contrast to aluminium adjuvant, MPL did not increase bead transport by DC at the later time point. These studies provide important new insights in the in vivo action of different adjuvants and the initial events that set up an immune response after vaccination." @default.
• W2015678334 created "2016-06-24" @default.
• W2015678334 creator A5006196924 @default.
• W2015678334 creator A5022966422 @default.
• W2015678334 creator A5067969485 @default.
• W2015678334 creator A5088496687 @default.
• W2015678334 creator A5088543531 @default.
• W2015678334 date "2011-06-07" @default.
• W2015678334 modified "2023-09-26" @default.
• W2015678334 title "Modulation of soluble and particulate antigen transport in afferent lymph by monophosphoryl lipid A" @default.
• W2015678334 cites W134775047 @default.
• W2015678334 cites W1977171479 @default.
• W2015678334 cites W1979872218 @default.
• W2015678334 cites W1991701295 @default.
• W2015678334 cites W1995073019 @default.
• W2015678334 cites W2005631373 @default.
• W2015678334 cites W2022890571 @default.
• W2015678334 cites W2023491212 @default.
• W2015678334 cites W2025904060 @default.
• W2015678334 cites W2029373703 @default.
• W2015678334 cites W2037380046 @default.
• W2015678334 cites W2041982399 @default.
• W2015678334 cites W2049062183 @default.
• W2015678334 cites W2056927031 @default.
• W2015678334 cites W2061178426 @default.
• W2015678334 cites W2086829937 @default.
• W2015678334 cites W2096729904 @default.
• W2015678334 cites W2098084836 @default.
• W2015678334 cites W2099388162 @default.
• W2015678334 cites W2118627537 @default.
• W2015678334 cites W2121859555 @default.
• W2015678334 cites W2123223407 @default.
• W2015678334 cites W2130989367 @default.
• W2015678334 cites W2135720956 @default.
• W2015678334 cites W2135721651 @default.
• W2015678334 cites W2169324807 @default.
• W2015678334 cites W4313377092 @default.
• W2015678334 doi "https://doi.org/10.1038/icb.2011.53" @default.
• W2015678334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21647169" @default.
• W2015678334 hasPublicationYear "2011" @default.
• W2015678334 type Work @default.
• W2015678334 sameAs 2015678334 @default.
• W2015678334 citedByCount "17" @default.
• W2015678334 countsByYear W20156783342013 @default.
• W2015678334 countsByYear W20156783342014 @default.
• W2015678334 countsByYear W20156783342015 @default.
• W2015678334 countsByYear W20156783342016 @default.
• W2015678334 countsByYear W20156783342018 @default.
• W2015678334 crossrefType "journal-article" @default.
• W2015678334 hasAuthorship W2015678334A5006196924 @default.
• W2015678334 hasAuthorship W2015678334A5022966422 @default.
• W2015678334 hasAuthorship W2015678334A5067969485 @default.
• W2015678334 hasAuthorship W2015678334A5088496687 @default.
• W2015678334 hasAuthorship W2015678334A5088543531 @default.
• W2015678334 hasConcept C142724271 @default.
• W2015678334 hasConcept C144464004 @default.
• W2015678334 hasConcept C147483822 @default.
• W2015678334 hasConcept C181152851 @default.
• W2015678334 hasConcept C185592680 @default.
• W2015678334 hasConcept C202751555 @default.
• W2015678334 hasConcept C203014093 @default.
• W2015678334 hasConcept C26291073 @default.
• W2015678334 hasConcept C2776946954 @default.
• W2015678334 hasConcept C2777863537 @default.
• W2015678334 hasConcept C2778170410 @default.
• W2015678334 hasConcept C2778754761 @default.
• W2015678334 hasConcept C2779720271 @default.
• W2015678334 hasConcept C55493867 @default.
• W2015678334 hasConcept C71924100 @default.
• W2015678334 hasConcept C86803240 @default.
• W2015678334 hasConcept C8891405 @default.
• W2015678334 hasConcept C98274493 @default.
• W2015678334 hasConceptScore W2015678334C142724271 @default.
• W2015678334 hasConceptScore W2015678334C144464004 @default.
• W2015678334 hasConceptScore W2015678334C147483822 @default.
• W2015678334 hasConceptScore W2015678334C181152851 @default.
• W2015678334 hasConceptScore W2015678334C185592680 @default.
• W2015678334 hasConceptScore W2015678334C202751555 @default.
• W2015678334 hasConceptScore W2015678334C203014093 @default.
• W2015678334 hasConceptScore W2015678334C26291073 @default.
• W2015678334 hasConceptScore W2015678334C2776946954 @default.
• W2015678334 hasConceptScore W2015678334C2777863537 @default.
• W2015678334 hasConceptScore W2015678334C2778170410 @default.
• W2015678334 hasConceptScore W2015678334C2778754761 @default.
• W2015678334 hasConceptScore W2015678334C2779720271 @default.
• W2015678334 hasConceptScore W2015678334C55493867 @default.
• W2015678334 hasConceptScore W2015678334C71924100 @default.
• W2015678334 hasConceptScore W2015678334C86803240 @default.
• W2015678334 hasConceptScore W2015678334C8891405 @default.
• W2015678334 hasConceptScore W2015678334C98274493 @default.
• W2015678334 hasIssue "4" @default.
• W2015678334 hasLocation W20156783341 @default.
• W2015678334 hasLocation W20156783342 @default.
• W2015678334 hasOpenAccess W2015678334 @default.
• W2015678334 hasPrimaryLocation W20156783341 @default.
• W2015678334 hasRelatedWork W1983325185 @default.
• W2015678334 hasRelatedWork W2033998433 @default.
• W2015678334 hasRelatedWork W2093242067 @default.

• next