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- W2015680329 abstract "The function of T cell antigen receptor (TCR) specificity in thymic regulatory T cell development is controversial. Hsieh and colleagues show that this development is a 'TCR-instructive' process that depends on a small selecting niche Because the deletion of self-reactive T cells is incomplete, thymic development of natural Foxp3+CD4+ regulatory T cells (Treg cells) is required for preventing autoimmunity. However, the function of T cell antigen receptor (TCR) specificity in thymic Treg cell development remains controversial. To address this issue, we generated a transgenic line expressing a naturally occurring Treg cell–derived TCR. Unexpectedly, we found that efficient thymic Treg cell development occurred only when the antigen-specific Treg cell precursors were present at low clonal frequency (<1%) in a normal thymus. Using retroviral vectors and bone marrow chimeras, we observed similar activity with two other Treg cell–derived TCRs. Our data demonstrate that thymic Treg cell development is a 'TCR-instructive' process involving a niche that can be saturable at much lower clonal frequencies than is the niche for positive selection." @default.
- W2015680329 created "2016-06-24" @default.
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- W2015680329 date "2009-05-10" @default.
- W2015680329 modified "2023-10-17" @default.
- W2015680329 title "Intraclonal competition limits the fate determination of regulatory T cells in the thymus" @default.
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- W2015680329 doi "https://doi.org/10.1038/ni.1739" @default.
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