FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015682764> ?p ?o ?g. }

• W2015682764 endingPage "294" @default.
• W2015682764 startingPage "285" @default.
• W2015682764 abstract "A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent protective responses. By contrast, type 2 Th (Th2) cells produce IL-4, IL-5, IL-10, and IL-13, which are responsible for strong antibody production, eosinophil activation, and inhibition of several macrophage functions, thus providing phagocyte-independent protective responses. Th1 cells mainly develop following infections by intracellular bacteria and some viruses, whereas Th2 cells predominate in response to infestations by gastrointestinal nematodes. Polarized Th1 and Th2 cells not only exhibit different functional properties, but also show the preferential expression of some activation markers and distinct transcription factors. Several mechanisms may influence the Th cell differentiation, which include the cytokine profile of natural immunity evoked by different offending agents, the nature of the peptide ligand, as well as the activity of some costimulatory molecules and microenvironmentally secreted hormones, in the context of the individual genetic background. In addition to playing different roles in protection, polarized Th1-type and Th2-type responses are also responsible for different types of immunopathological reactions. Th1 cells are involved in the pathogenesis of organ-specific autoimmune disorders, Crohn's disease, Helicobacter pylori-induced peptic ulcer, acute kidney allograft rejection, and unexplained recurrent abortions. In contrast, allergen-specific Th2 responses are responsible for atopic disorders in genetically susceptible individuals. Moreover, Th2 responses against still unknown antigens predominate in Omenn's syndrome, idiopathic pulmonary fibrosis, and progressive systemic sclerosis. Finally, the prevalence of Th2 responses may play some role in a more rapid evolution of human immunodeficiency virus infection to the full-blown disease. The Th1/Th2 paradigm also provides the rationale for the development of new types of vaccines against infectious agents and of novel strategies for the therapy of allergic and autoimmune disorders." @default.
• W2015682764 created "2016-06-24" @default.
• W2015682764 creator A5082999407 @default.
• W2015682764 date "1999-11-01" @default.
• W2015682764 modified "2023-10-17" @default.
• W2015682764 title "Th1/Th2 Cells" @default.
• W2015682764 cites W1590191111 @default.
• W2015682764 cites W1597170724 @default.
• W2015682764 cites W1648671938 @default.
• W2015682764 cites W1898357572 @default.
• W2015682764 cites W1946088674 @default.
• W2015682764 cites W1966679064 @default.
• W2015682764 cites W1972922050 @default.
• W2015682764 cites W1976186260 @default.
• W2015682764 cites W1979514172 @default.
• W2015682764 cites W1980000158 @default.
• W2015682764 cites W1982005094 @default.
• W2015682764 cites W1982857233 @default.
• W2015682764 cites W1983895762 @default.
• W2015682764 cites W1988707760 @default.
• W2015682764 cites W1990197546 @default.
• W2015682764 cites W1990214233 @default.
• W2015682764 cites W1997335202 @default.
• W2015682764 cites W1997638368 @default.
• W2015682764 cites W1999641867 @default.
• W2015682764 cites W2000887422 @default.
• W2015682764 cites W2001713238 @default.
• W2015682764 cites W2002186586 @default.
• W2015682764 cites W2003310898 @default.
• W2015682764 cites W2004313295 @default.
• W2015682764 cites W2005992769 @default.
• W2015682764 cites W2007661898 @default.
• W2015682764 cites W2011038290 @default.
• W2015682764 cites W2017336448 @default.
• W2015682764 cites W2018106173 @default.
• W2015682764 cites W2020977425 @default.
• W2015682764 cites W2021566548 @default.
• W2015682764 cites W2022760428 @default.
• W2015682764 cites W2024931925 @default.
• W2015682764 cites W2026161448 @default.
• W2015682764 cites W2027180323 @default.
• W2015682764 cites W2027388989 @default.
• W2015682764 cites W2027699993 @default.
• W2015682764 cites W2029860358 @default.
• W2015682764 cites W2031501484 @default.
• W2015682764 cites W2032189068 @default.
• W2015682764 cites W2032260549 @default.
• W2015682764 cites W2035572849 @default.
• W2015682764 cites W2038894130 @default.
• W2015682764 cites W2042282764 @default.
• W2015682764 cites W2042952724 @default.
• W2015682764 cites W2045204229 @default.
• W2015682764 cites W2048634881 @default.
• W2015682764 cites W2053560001 @default.
• W2015682764 cites W2055753399 @default.
• W2015682764 cites W2056958245 @default.
• W2015682764 cites W2058091324 @default.
• W2015682764 cites W2064793834 @default.
• W2015682764 cites W2067049479 @default.
• W2015682764 cites W2067548078 @default.
• W2015682764 cites W2067714902 @default.
• W2015682764 cites W2076742348 @default.
• W2015682764 cites W2084129498 @default.
• W2015682764 cites W2085114981 @default.
• W2015682764 cites W2085396070 @default.
• W2015682764 cites W2087372329 @default.
• W2015682764 cites W2087717265 @default.
• W2015682764 cites W2088461720 @default.
• W2015682764 cites W2091301099 @default.
• W2015682764 cites W2091813006 @default.
• W2015682764 cites W2095351296 @default.
• W2015682764 cites W2098721048 @default.
• W2015682764 cites W2102440756 @default.
• W2015682764 cites W2102927493 @default.
• W2015682764 cites W2108257606 @default.
• W2015682764 cites W2109338978 @default.
• W2015682764 cites W2109506765 @default.
• W2015682764 cites W2117040776 @default.
• W2015682764 cites W2117342688 @default.
• W2015682764 cites W2117761826 @default.
• W2015682764 cites W2119631902 @default.
• W2015682764 cites W2119751920 @default.
• W2015682764 cites W2122892658 @default.
• W2015682764 cites W2124116262 @default.
• W2015682764 cites W2126068224 @default.
• W2015682764 cites W2140066663 @default.
• W2015682764 cites W2140096667 @default.
• W2015682764 cites W2141289657 @default.
• W2015682764 cites W2143885071 @default.
• W2015682764 cites W2144281476 @default.
• W2015682764 cites W2145721468 @default.
• W2015682764 cites W2147627497 @default.
• W2015682764 cites W2150488197 @default.
• W2015682764 cites W2157605618 @default.
• W2015682764 cites W2161485037 @default.
• W2015682764 cites W2168115358 @default.
• W2015682764 cites W2170206314 @default.
• W2015682764 cites W2172466148 @default.

• next