FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015687515> ?p ?o ?g. }

• W2015687515 endingPage "2451" @default.
• W2015687515 startingPage "2442" @default.
• W2015687515 abstract "In CLL data from chromosome banding analysis (CBA) have been scarce due to the low proliferative activity of CLL cells in vitro. We improved the cultivation technique using an immunostimulatory CpG-oligonucleotide DSP30 and IL-2. A total of 506 CLL samples were analysed with CBA and interphase FISH using probes for the detection of trisomy 12, IgH rearrangements and deletions of 6q21, 11q22.3 (ATM), 13q14 (D13S25 and D13S319) and 17p13 (TP53). A total of 500 of 506 (98.8%) cases were successfully stimulated for metaphase generation and are subject to this study. Aberrations were detected in 415 of 500 (83.0%) cases by CBA and in 392 of 500 (78.4%) cases by FISH. CBA detected 832 abnormalities and FISH only 502. Therefore, CBA offers important information in addition to FISH. (1) CLL is characterized mainly by genomic imbalances and reciprocal translocations are rare. (2) A subgroup with complex aberrant karyotype (16.4%) is identified which is associated with an unmutated IgVH status and CD38 expression (P=0.034 and 0.02, respectively). (3) Additional abnormalities are detectable providing new biological insights into different CLL subclasses revealing a much more heterogeneous pattern of cytogenetic abnormalities as assumed so far based on FISH data only. Therefore, prospective clinical trials should evaluate the prognostic impact of newly available CBA data." @default.
• W2015687515 created "2016-06-24" @default.
• W2015687515 creator A5021480569 @default.
• W2015687515 creator A5023137678 @default.
• W2015687515 creator A5043414993 @default.
• W2015687515 creator A5048388170 @default.
• W2015687515 creator A5082454763 @default.
• W2015687515 date "2007-09-06" @default.
• W2015687515 modified "2023-10-15" @default.
• W2015687515 title "Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgVH status and immunophenotyping" @default.
• W2015687515 cites W1243376384 @default.
• W2015687515 cites W1564039428 @default.
• W2015687515 cites W1587836835 @default.
• W2015687515 cites W1832459253 @default.
• W2015687515 cites W187238933 @default.
• W2015687515 cites W1966456937 @default.
• W2015687515 cites W1976814214 @default.
• W2015687515 cites W1981570437 @default.
• W2015687515 cites W2006486191 @default.
• W2015687515 cites W2010342942 @default.
• W2015687515 cites W2011803705 @default.
• W2015687515 cites W2017960943 @default.
• W2015687515 cites W2021964934 @default.
• W2015687515 cites W2022736043 @default.
• W2015687515 cites W2034382420 @default.
• W2015687515 cites W2037798465 @default.
• W2015687515 cites W2039356250 @default.
• W2015687515 cites W2042404701 @default.
• W2015687515 cites W2053895312 @default.
• W2015687515 cites W2057796341 @default.
• W2015687515 cites W2062937743 @default.
• W2015687515 cites W2069792748 @default.
• W2015687515 cites W2074630414 @default.
• W2015687515 cites W2078673385 @default.
• W2015687515 cites W2086637735 @default.
• W2015687515 cites W2107615815 @default.
• W2015687515 cites W2115577067 @default.
• W2015687515 cites W2117617134 @default.
• W2015687515 cites W2133339616 @default.
• W2015687515 cites W2136628513 @default.
• W2015687515 cites W2142741025 @default.
• W2015687515 cites W2150831607 @default.
• W2015687515 cites W2153188399 @default.
• W2015687515 cites W2159880472 @default.
• W2015687515 cites W2265729689 @default.
• W2015687515 cites W2278193989 @default.
• W2015687515 cites W2318327698 @default.
• W2015687515 cites W2318933236 @default.
• W2015687515 cites W2473561901 @default.
• W2015687515 cites W304227101 @default.
• W2015687515 cites W3127670826 @default.
• W2015687515 cites W4231225179 @default.
• W2015687515 doi "https://doi.org/10.1038/sj.leu.2404935" @default.
• W2015687515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17805327" @default.
• W2015687515 hasPublicationYear "2007" @default.
• W2015687515 type Work @default.
• W2015687515 sameAs 2015687515 @default.
• W2015687515 citedByCount "310" @default.
• W2015687515 countsByYear W20156875152012 @default.
• W2015687515 countsByYear W20156875152013 @default.
• W2015687515 countsByYear W20156875152014 @default.
• W2015687515 countsByYear W20156875152015 @default.
• W2015687515 countsByYear W20156875152016 @default.
• W2015687515 countsByYear W20156875152017 @default.
• W2015687515 countsByYear W20156875152018 @default.
• W2015687515 countsByYear W20156875152019 @default.
• W2015687515 countsByYear W20156875152020 @default.
• W2015687515 countsByYear W20156875152021 @default.
• W2015687515 countsByYear W20156875152022 @default.
• W2015687515 countsByYear W20156875152023 @default.
• W2015687515 crossrefType "journal-article" @default.
• W2015687515 hasAuthorship W2015687515A5021480569 @default.
• W2015687515 hasAuthorship W2015687515A5023137678 @default.
• W2015687515 hasAuthorship W2015687515A5043414993 @default.
• W2015687515 hasAuthorship W2015687515A5048388170 @default.
• W2015687515 hasAuthorship W2015687515A5082454763 @default.
• W2015687515 hasBestOaLocation W20156875151 @default.
• W2015687515 hasConcept C10205521 @default.
• W2015687515 hasConcept C104317684 @default.
• W2015687515 hasConcept C138626823 @default.
• W2015687515 hasConcept C153911025 @default.
• W2015687515 hasConcept C159912055 @default.
• W2015687515 hasConcept C174475383 @default.
• W2015687515 hasConcept C196166836 @default.
• W2015687515 hasConcept C203014093 @default.
• W2015687515 hasConcept C206936463 @default.
• W2015687515 hasConcept C2776229224 @default.
• W2015687515 hasConcept C2777938653 @default.
• W2015687515 hasConcept C2778461978 @default.
• W2015687515 hasConcept C28328180 @default.
• W2015687515 hasConcept C30481170 @default.
• W2015687515 hasConcept C53226629 @default.
• W2015687515 hasConcept C54355233 @default.
• W2015687515 hasConcept C553184892 @default.
• W2015687515 hasConcept C70278784 @default.
• W2015687515 hasConcept C86803240 @default.
• W2015687515 hasConceptScore W2015687515C10205521 @default.
• W2015687515 hasConceptScore W2015687515C104317684 @default.

• next