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• W2015687746 abstract "The temporal order of replication of several genes was studied in 10T1/2 cells synchronized by release from confluence-induced arrest of proliferation followed by treatment with 2 μg/mL aphidicolin for 24 h. DNA subjected to bromodeoxyuridine substitution for 1- or 2-h intervals spanning the S phase was separated from the remaining DNA in cesium chloride gradients, filtered onto nitrocellulose in a slot-blot apparatus, and hybridized with various 32P-labeled probes. Ha-ras was among the first genes replicated at the onset of the S phase. The myc proto-oncogene replicated later but within the first hour of the S phase. The replication of Ki-ras, raf, and mos was detected between hour 1 and 2 of the S phase. The dihydrofolate reductase gene replicated early (0–2 h) and the myb proto-oncogene replicated in mid-S phase (2–4 h). An immunoglobulin VH sequence and the β-globin gene replicated late in 10T1/2 cells, 4–6 h after removal of aphidicolin. Replicating DNA is preferentially adducted by chemical carcinogens, and replication of damaged proto-oncogenes before they are repaired may activate their transforming potential. Therefore, the observed replication of protooncogenes during the early S phase may underlie the enhanced sensitivity of 10T1/2 cells to chemically induced transformation at this point in the cell cycle." @default.
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• W2015687746 date "1988-01-01" @default.
• W2015687746 modified "2023-09-25" @default.
• W2015687746 title "Timing of proto-oncogene replication: A possible determinant of early S phase sensitivity of C3H 10T1/2 cells to transformation by chemical carcinogens" @default.
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• W2015687746 doi "https://doi.org/10.1002/mc.2940010110" @default.
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