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- W2015697238 abstract "Revised research criteria for AD include its prodromal stage when dementia is not yet diagnosable. Clinical trials in prodromal AD will require outcome measures that reliably capture the transition to the dementia stage. Currently, this transition is based on clinician's judgement. We hypothesized that ratings and cut points on the Clinical Dementia Rating Scale (CDR) and Functional Assessment Questionaire (FAQ) would be able to capture this transition. 1. To evaluate the relationship between the clinician determined AD transition and levels of impairment on the CDR and FAQ. 2. To determine potential cut points on the CDR and the FAQ that correlate best with clinician determined AD transition. A retrospective analysis from the ADNI data base (Nov 10, 2008) comparing a group of MCI subjects progressing to the dementia phase of AD(MCI-p) within 18 months (n=101) with a group not progressing (MCI-n) (n=209) during this followup. MCI-p was established by the investigator per the ADNI protocol. Descriptive statistics (frequencies, means, standard deviations) were employed with comparisons using t-tests and Fisher's Exact tests. At baseline the MCI-p and MCI-n groups had comparable mean ages (74.9 ± 7.0 vs 74.4 ± 7.4), mean years of education (15.5 ± 2.9, 16.0 ± 2.9), and gender. There were significant differences in Apo E4 + (65% vs 50%, p= 0.01), baseline MMSE (26.5 ± 1.8 vs 27.3 ± 1.7, p<0.001), CDR SOB (2.0 ± 1.0 vs 1.4 ± 0.8, p<0.001), CDR non-cognitive subscore (0.6 ± 0.6 vs 0.4 ± 0.5, p=0.0025) and total FAQ (6.3 ± 5.1 vs 2.8 ± 3.8, p<0.0001). In the overall group, the median value on CDR-SOB was 2.0, CDR non-cognitive subscore 0.5, and total FAQ 5.0. Subjects at or above the overall median values for the MCI-p and MCI-n groups respectively were: CDR SOB (96% vs. 47%, p<0.0001), CDR non cognitive subscore (92% vs. 53%, p<0.0001), total FAQ (89% vs. 35%, p<0.0001). Median cut points on the CDR, its non-cognitive subscore and the FAQ have excellent sensitivity in identifying the clinicians determined transition to AD. However, further research is needed to improve the specificity of these potential cut points." @default.
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- W2015697238 date "2009-07-01" @default.
- W2015697238 modified "2023-10-16" @default.
- W2015697238 title "P3-072: Assessing outcome measures for prodromal AD clinical trials: A retrospective analysis from the ADNI database" @default.
- W2015697238 doi "https://doi.org/10.1016/j.jalz.2009.04.1148" @default.
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