Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015698721> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2015698721 endingPage "215" @default.
- W2015698721 startingPage "209" @default.
- W2015698721 abstract "Translational control is one of the mechanisms that regulate thymidine kinase (TK) expression in the cell cycle. Evidence for the TK mRNA sequence that is involved in its own translation has been lacking. In this report, we show that TK-deficient mouse fibroblasts transfected with pFLAG-TK express a TK mRNA containing the 5'-untranslated region (5'UTR) and produce two polypeptides, FLAG-TK and TK, resulting from an alternative initiation of translation. Most interestingly, the 5'UTR of TK allowed the translation of FLAG-TK mRNA to become cap-independent in an in vitro translation system. Furthermore, this 5'UTR sequence decreased significantly the efficiency of translation from the AUG codon of FLAG when the concentration of FLAG-TK RNA was low. Here, we also show that in normal human IMR-90 fibroblasts the induction of TK polypeptide by serum stimulation is insensitive to rapamycin treatment, which is known to inhibit the translations of transcripts of some growth-controlled genes by affecting the cap-binding efficiency. Taken together, we propose that the 5'UTR in TK mRNA might actually confer a secondary structure to regulate ribosome binding during translation in a cap-independent manner." @default.
- W2015698721 created "2016-06-24" @default.
- W2015698721 creator A5037058330 @default.
- W2015698721 creator A5049073157 @default.
- W2015698721 date "2001-06-01" @default.
- W2015698721 modified "2023-09-24" @default.
- W2015698721 title "Cap-independent translation conferred by the 5′-untranslated region of human thymidine kinase mRNA" @default.
- W2015698721 cites W1516043257 @default.
- W2015698721 cites W1529552889 @default.
- W2015698721 cites W1555689915 @default.
- W2015698721 cites W1591229203 @default.
- W2015698721 cites W1591455649 @default.
- W2015698721 cites W1761872749 @default.
- W2015698721 cites W1803826664 @default.
- W2015698721 cites W1859008192 @default.
- W2015698721 cites W1920555941 @default.
- W2015698721 cites W1949632792 @default.
- W2015698721 cites W1972866924 @default.
- W2015698721 cites W1975830976 @default.
- W2015698721 cites W1979877802 @default.
- W2015698721 cites W1981535645 @default.
- W2015698721 cites W1994500923 @default.
- W2015698721 cites W1999891875 @default.
- W2015698721 cites W2007212263 @default.
- W2015698721 cites W2020251645 @default.
- W2015698721 cites W2020721543 @default.
- W2015698721 cites W2023844393 @default.
- W2015698721 cites W2025763720 @default.
- W2015698721 cites W2050666820 @default.
- W2015698721 cites W2057080108 @default.
- W2015698721 cites W2060809861 @default.
- W2015698721 cites W2086899319 @default.
- W2015698721 cites W2126493366 @default.
- W2015698721 cites W2168847939 @default.
- W2015698721 cites W56813229 @default.
- W2015698721 doi "https://doi.org/10.1016/s0167-4781(01)00241-x" @default.
- W2015698721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11418187" @default.
- W2015698721 hasPublicationYear "2001" @default.
- W2015698721 type Work @default.
- W2015698721 sameAs 2015698721 @default.
- W2015698721 citedByCount "8" @default.
- W2015698721 crossrefType "journal-article" @default.
- W2015698721 hasAuthorship W2015698721A5037058330 @default.
- W2015698721 hasAuthorship W2015698721A5049073157 @default.
- W2015698721 hasConcept C104317684 @default.
- W2015698721 hasConcept C105580179 @default.
- W2015698721 hasConcept C12464233 @default.
- W2015698721 hasConcept C149364088 @default.
- W2015698721 hasConcept C153911025 @default.
- W2015698721 hasConcept C161295673 @default.
- W2015698721 hasConcept C22667442 @default.
- W2015698721 hasConcept C2522874641 @default.
- W2015698721 hasConcept C2775992057 @default.
- W2015698721 hasConcept C2776147627 @default.
- W2015698721 hasConcept C2781196997 @default.
- W2015698721 hasConcept C3675279 @default.
- W2015698721 hasConcept C54355233 @default.
- W2015698721 hasConcept C86803240 @default.
- W2015698721 hasConcept C89604277 @default.
- W2015698721 hasConcept C95444343 @default.
- W2015698721 hasConceptScore W2015698721C104317684 @default.
- W2015698721 hasConceptScore W2015698721C105580179 @default.
- W2015698721 hasConceptScore W2015698721C12464233 @default.
- W2015698721 hasConceptScore W2015698721C149364088 @default.
- W2015698721 hasConceptScore W2015698721C153911025 @default.
- W2015698721 hasConceptScore W2015698721C161295673 @default.
- W2015698721 hasConceptScore W2015698721C22667442 @default.
- W2015698721 hasConceptScore W2015698721C2522874641 @default.
- W2015698721 hasConceptScore W2015698721C2775992057 @default.
- W2015698721 hasConceptScore W2015698721C2776147627 @default.
- W2015698721 hasConceptScore W2015698721C2781196997 @default.
- W2015698721 hasConceptScore W2015698721C3675279 @default.
- W2015698721 hasConceptScore W2015698721C54355233 @default.
- W2015698721 hasConceptScore W2015698721C86803240 @default.
- W2015698721 hasConceptScore W2015698721C89604277 @default.
- W2015698721 hasConceptScore W2015698721C95444343 @default.
- W2015698721 hasIssue "3" @default.
- W2015698721 hasLocation W20156987211 @default.
- W2015698721 hasLocation W20156987212 @default.
- W2015698721 hasOpenAccess W2015698721 @default.
- W2015698721 hasPrimaryLocation W20156987211 @default.
- W2015698721 hasRelatedWork W1998128885 @default.
- W2015698721 hasRelatedWork W2015698721 @default.
- W2015698721 hasRelatedWork W2019400899 @default.
- W2015698721 hasRelatedWork W2063058717 @default.
- W2015698721 hasRelatedWork W2077921152 @default.
- W2015698721 hasRelatedWork W2114859361 @default.
- W2015698721 hasRelatedWork W2132568558 @default.
- W2015698721 hasRelatedWork W2271083769 @default.
- W2015698721 hasRelatedWork W4308517608 @default.
- W2015698721 hasRelatedWork W4313210658 @default.
- W2015698721 hasVolume "1519" @default.
- W2015698721 isParatext "false" @default.
- W2015698721 isRetracted "false" @default.
- W2015698721 magId "2015698721" @default.
- W2015698721 workType "article" @default.