FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015707448> ?p ?o ?g. }

• W2015707448 endingPage "263" @default.
• W2015707448 startingPage "259" @default.
• W2015707448 abstract "The object of this study was to determine if the newly developed phenanthridine derivative, CY 208-243, retains its apparent in vivo preference for dopamine D-1 receptors under conditions of dopamine depletion, as a starting point to understanding why CY 208-243 possesses antiparkinson activity and the selective D-1 agonist SKF 38393 does not. Three hours after receiving reserpine (5 mg/kg), mice were strongly sedated and completely unresponsive to the motor stimulant effects of CY 208-243 (0.1-10 mg/kg) or the selective D-2 agonist RU 24213 (0.5-5 mg/kg) administered alone. After 24 h reserpine, the akinesia was partially and dose-dependent reversed by both CY 208-243 (0.1-10 mg/kg) and RU 24213 (0.5-5 mg/kg) alone. CY 208-243 also stimulated rearing and grooming, while RU 24213 gave rise to strong head-down sniffing. The response to 1 mg/kg CY 208-243 was practically abolished by pretreatment with the D-1 antagonist SCH 23390 (0.2 mg/kg). On the other hand, blocking D-2 receptors with metoclopramide (0.25 mg/kg) unexpectedly facilitated CY 208-243-induced locomotion and rearing, but suppressed grooming. When CY 208-243 (1 mg/kg) was injected together with RU 24213 (0.5-5 mg/kg), the two drugs interacted synergistically to stimulate locomotion at all times after reserpine. These animals also exhibited a greater preponderance of grooming, sniffing, gnawing and oral dyskinesia. Apart from the potentiation of some elements of CY 208-243-stimulated motor behaviour by D-2 blockade, these results are qualitatively indistinguishable from those previously obtained with the prototype D-1 agonist SKF 38393.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2015707448 created "2016-06-24" @default.
• W2015707448 creator A5002921078 @default.
• W2015707448 creator A5003403640 @default.
• W2015707448 creator A5067273679 @default.
• W2015707448 date "1991-02-01" @default.
• W2015707448 modified "2023-09-27" @default.
• W2015707448 title "CY 208–243 behaves as a typical D-1 agonist in the reserpine-treated mouse" @default.
• W2015707448 cites W1559792190 @default.
• W2015707448 cites W1966176551 @default.
• W2015707448 cites W1973512436 @default.
• W2015707448 cites W1976856793 @default.
• W2015707448 cites W1983995864 @default.
• W2015707448 cites W1986090218 @default.
• W2015707448 cites W1986353650 @default.
• W2015707448 cites W1987126397 @default.
• W2015707448 cites W1987193373 @default.
• W2015707448 cites W1987949176 @default.
• W2015707448 cites W1993905365 @default.
• W2015707448 cites W1994769900 @default.
• W2015707448 cites W2008898465 @default.
• W2015707448 cites W2009536591 @default.
• W2015707448 cites W2010299478 @default.
• W2015707448 cites W2011542286 @default.
• W2015707448 cites W2019213325 @default.
• W2015707448 cites W2028697314 @default.
• W2015707448 cites W2033412830 @default.
• W2015707448 cites W2035899528 @default.
• W2015707448 cites W2037497196 @default.
• W2015707448 cites W2042542014 @default.
• W2015707448 cites W2047197446 @default.
• W2015707448 cites W2049368274 @default.
• W2015707448 cites W2050284549 @default.
• W2015707448 cites W2051414078 @default.
• W2015707448 cites W2067901223 @default.
• W2015707448 cites W2069639335 @default.
• W2015707448 cites W2072822407 @default.
• W2015707448 cites W2073586713 @default.
• W2015707448 cites W2086013684 @default.
• W2015707448 cites W2089154427 @default.
• W2015707448 cites W2091813848 @default.
• W2015707448 doi "https://doi.org/10.1016/0091-3057(91)90275-7" @default.
• W2015707448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1676166" @default.
• W2015707448 hasPublicationYear "1991" @default.
• W2015707448 type Work @default.
• W2015707448 sameAs 2015707448 @default.
• W2015707448 citedByCount "21" @default.
• W2015707448 countsByYear W20157074482012 @default.
• W2015707448 countsByYear W20157074482015 @default.
• W2015707448 countsByYear W20157074482016 @default.
• W2015707448 countsByYear W20157074482023 @default.
• W2015707448 crossrefType "journal-article" @default.
• W2015707448 hasAuthorship W2015707448A5002921078 @default.
• W2015707448 hasAuthorship W2015707448A5003403640 @default.
• W2015707448 hasAuthorship W2015707448A5067273679 @default.
• W2015707448 hasConcept C126322002 @default.
• W2015707448 hasConcept C131722271 @default.
• W2015707448 hasConcept C134018914 @default.
• W2015707448 hasConcept C169760540 @default.
• W2015707448 hasConcept C170493617 @default.
• W2015707448 hasConcept C185592680 @default.
• W2015707448 hasConcept C2776885963 @default.
• W2015707448 hasConcept C2777525119 @default.
• W2015707448 hasConcept C2777842393 @default.
• W2015707448 hasConcept C2778479196 @default.
• W2015707448 hasConcept C2778938600 @default.
• W2015707448 hasConcept C2779026782 @default.
• W2015707448 hasConcept C2779134260 @default.
• W2015707448 hasConcept C2779734285 @default.
• W2015707448 hasConcept C2779917531 @default.
• W2015707448 hasConcept C2780304432 @default.
• W2015707448 hasConcept C2780852908 @default.
• W2015707448 hasConcept C2781353949 @default.
• W2015707448 hasConcept C513476851 @default.
• W2015707448 hasConcept C55493867 @default.
• W2015707448 hasConcept C71924100 @default.
• W2015707448 hasConcept C86803240 @default.
• W2015707448 hasConcept C98274493 @default.
• W2015707448 hasConceptScore W2015707448C126322002 @default.
• W2015707448 hasConceptScore W2015707448C131722271 @default.
• W2015707448 hasConceptScore W2015707448C134018914 @default.
• W2015707448 hasConceptScore W2015707448C169760540 @default.
• W2015707448 hasConceptScore W2015707448C170493617 @default.
• W2015707448 hasConceptScore W2015707448C185592680 @default.
• W2015707448 hasConceptScore W2015707448C2776885963 @default.
• W2015707448 hasConceptScore W2015707448C2777525119 @default.
• W2015707448 hasConceptScore W2015707448C2777842393 @default.
• W2015707448 hasConceptScore W2015707448C2778479196 @default.
• W2015707448 hasConceptScore W2015707448C2778938600 @default.
• W2015707448 hasConceptScore W2015707448C2779026782 @default.
• W2015707448 hasConceptScore W2015707448C2779134260 @default.
• W2015707448 hasConceptScore W2015707448C2779734285 @default.
• W2015707448 hasConceptScore W2015707448C2779917531 @default.
• W2015707448 hasConceptScore W2015707448C2780304432 @default.
• W2015707448 hasConceptScore W2015707448C2780852908 @default.
• W2015707448 hasConceptScore W2015707448C2781353949 @default.
• W2015707448 hasConceptScore W2015707448C513476851 @default.
• W2015707448 hasConceptScore W2015707448C55493867 @default.

• next