FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015724488> ?p ?o ?g. }

• W2015724488 endingPage "541" @default.
• W2015724488 startingPage "530" @default.
• W2015724488 abstract "Understanding how the information is coded in large neuronal networks is one of the major challenges for neuroscience. A possible approach to investigate the information processing capabilities of the neuronal ensembles is given by the use of dissociated neuronal cultures coupled to microelectrode arrays (MEAs). Here, we describe a new strategy, based on MEAs, for studying in vitro neuronal network dynamics in interconnected sub-populations of cortical neurons. The rationale is to sub-divide the neuronal network into communicating clusters while preserving a high degree of functional connectivity within each confined sub-population, i.e. to achieve a compromise between a completely random large neuronal population and a patterned network, such as currently used with conventional MEAs. To this end, we have realized and functionally characterized a Pt microelectrode array with an integrated EPON SU-8 clustering structure, allowing to confine five relatively large yet interconnected spontaneously developing neuronal networks (i.e. thousands of cells). The clustering structure consists of five chambers of 3 mm in diameter interconnected via 800 μm long and 300 μm wide microchannels and is integrated on the MEA of 60 thin-film Pt electrodes of 30 μm diameter. Tests of the Pt microelectrodes’ stability under stimulation showed a stable behavior up to 35,000 voltage stimuli and the biocompatibility was assessed with the cultures of dissociated rat's cortical neurons achieving cultures’ viability up to 60 days in vitro. Compared to conventional MEAs, the monitoring of spontaneous and evoked activity and the computation of the Post-Stimulus Time Histogram (PSTH) within the clusters clearly demonstrates: (i) the capability to selectively activate (through poly-synaptic pathways) specific network regions and (ii) the confinement of the network dynamics mainly in the highly connected sub-networks." @default.
• W2015724488 created "2016-06-24" @default.
• W2015724488 creator A5002122862 @default.
• W2015724488 creator A5003681560 @default.
• W2015724488 creator A5010752863 @default.
• W2015724488 creator A5017434251 @default.
• W2015724488 creator A5032855935 @default.
• W2015724488 creator A5039367763 @default.
• W2015724488 creator A5046747801 @default.
• W2015724488 creator A5049123223 @default.
• W2015724488 creator A5057157181 @default.
• W2015724488 creator A5062444354 @default.
• W2015724488 creator A5088983421 @default.
• W2015724488 date "2006-03-01" @default.
• W2015724488 modified "2023-10-18" @default.
• W2015724488 title "A microelectrode array (MEA) integrated with clustering structures for investigating in vitro neurodynamics in confined interconnected sub-populations of neurons" @default.
• W2015724488 cites W1552650364 @default.
• W2015724488 cites W1557721542 @default.
• W2015724488 cites W1566787049 @default.
• W2015724488 cites W1641769423 @default.
• W2015724488 cites W1965381196 @default.
• W2015724488 cites W1966962106 @default.
• W2015724488 cites W1985803833 @default.
• W2015724488 cites W1989118286 @default.
• W2015724488 cites W1989276285 @default.
• W2015724488 cites W1998458595 @default.
• W2015724488 cites W2007580663 @default.
• W2015724488 cites W2011180511 @default.
• W2015724488 cites W2015913853 @default.
• W2015724488 cites W2025772448 @default.
• W2015724488 cites W2028064243 @default.
• W2015724488 cites W2029592532 @default.
• W2015724488 cites W2032519816 @default.
• W2015724488 cites W2036624290 @default.
• W2015724488 cites W2050753656 @default.
• W2015724488 cites W2051131629 @default.
• W2015724488 cites W2056046435 @default.
• W2015724488 cites W2071880755 @default.
• W2015724488 cites W2086037466 @default.
• W2015724488 cites W2093044760 @default.
• W2015724488 cites W2094978516 @default.
• W2015724488 cites W2095292856 @default.
• W2015724488 cites W2100243099 @default.
• W2015724488 cites W2100786548 @default.
• W2015724488 cites W2114079854 @default.
• W2015724488 cites W2116342814 @default.
• W2015724488 cites W2116760959 @default.
• W2015724488 cites W2120604647 @default.
• W2015724488 cites W2131672021 @default.
• W2015724488 cites W2143028346 @default.
• W2015724488 cites W2152529501 @default.
• W2015724488 cites W2171196856 @default.
• W2015724488 cites W4248522847 @default.
• W2015724488 doi "https://doi.org/10.1016/j.snb.2005.04.042" @default.
• W2015724488 hasPublicationYear "2006" @default.
• W2015724488 type Work @default.
• W2015724488 sameAs 2015724488 @default.
• W2015724488 citedByCount "86" @default.
• W2015724488 countsByYear W20157244882012 @default.
• W2015724488 countsByYear W20157244882013 @default.
• W2015724488 countsByYear W20157244882014 @default.
• W2015724488 countsByYear W20157244882015 @default.
• W2015724488 countsByYear W20157244882016 @default.
• W2015724488 countsByYear W20157244882017 @default.
• W2015724488 countsByYear W20157244882018 @default.
• W2015724488 countsByYear W20157244882019 @default.
• W2015724488 countsByYear W20157244882020 @default.
• W2015724488 countsByYear W20157244882021 @default.
• W2015724488 countsByYear W20157244882022 @default.
• W2015724488 countsByYear W20157244882023 @default.
• W2015724488 crossrefType "journal-article" @default.
• W2015724488 hasAuthorship W2015724488A5002122862 @default.
• W2015724488 hasAuthorship W2015724488A5003681560 @default.
• W2015724488 hasAuthorship W2015724488A5010752863 @default.
• W2015724488 hasAuthorship W2015724488A5017434251 @default.
• W2015724488 hasAuthorship W2015724488A5032855935 @default.
• W2015724488 hasAuthorship W2015724488A5039367763 @default.
• W2015724488 hasAuthorship W2015724488A5046747801 @default.
• W2015724488 hasAuthorship W2015724488A5049123223 @default.
• W2015724488 hasAuthorship W2015724488A5057157181 @default.
• W2015724488 hasAuthorship W2015724488A5062444354 @default.
• W2015724488 hasAuthorship W2015724488A5088983421 @default.
• W2015724488 hasConcept C111670793 @default.
• W2015724488 hasConcept C118403218 @default.
• W2015724488 hasConcept C127413603 @default.
• W2015724488 hasConcept C136229726 @default.
• W2015724488 hasConcept C147789679 @default.
• W2015724488 hasConcept C154945302 @default.
• W2015724488 hasConcept C15744967 @default.
• W2015724488 hasConcept C169760540 @default.
• W2015724488 hasConcept C17525397 @default.
• W2015724488 hasConcept C185263204 @default.
• W2015724488 hasConcept C185592680 @default.
• W2015724488 hasConcept C186060115 @default.
• W2015724488 hasConcept C192562407 @default.
• W2015724488 hasConcept C2779918689 @default.
• W2015724488 hasConcept C2908647359 @default.
• W2015724488 hasConcept C2983650178 @default.

• next