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• W2015740911 abstract "We have recently discovered imidazo[1,5-c]imidazol-3-one derivative 1 as a potent, selective, and orally bioavailable factor Xa (FXa) inhibitor. In this study, we have synthesized metabolites of 1 and evaluated their biological activities. As a result, we identified the active metabolites S-5 and 6 with a potent FXa inhibitory activity comparable to 1 and a favorable pharmacokinetic profile in monkeys." @default.
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• W2015740911 date "2009-12-01" @default.
• W2015740911 modified "2023-10-06" @default.
• W2015740911 title "Synthesis and biological evaluation of the metabolites of 2-(1-{3-[(6-chloronaphthalen-2-yl)sulfonyl]propanoyl}piperidin-4-yl)-5-methyl-1,2-dihydro-3H-imidazo[1,5-c]imidazol-3-one" @default.
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• W2015740911 doi "https://doi.org/10.1016/j.bmc.2009.10.009" @default.
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