FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015747109> ?p ?o ?g. }

• W2015747109 endingPage "1739" @default.
• W2015747109 startingPage "1732" @default.
• W2015747109 abstract "ABSTRACT The Escherichia coli outer membrane TonB-dependent transporters for iron complexes and cobalamins recognize their multiple and diverse substrates with high specificity and affinity. The X-ray crystallographic structures of several transporters show that the substrate-binding surfaces are comprised of residues from the internal globular domain and multiple extracellular loops. The extracellular loops on the N-terminal half of the transmembrane beta-barrel of the cobalamin transporter BtuB participate in binding of the cofactor calcium atoms and undergo substantial conformation changes upon substrate binding. The functional relevance of the five C-terminal loops was examined by examining the effects of short in-frame deletions. Each loop contributed in different ways to the binding of BtuB substrates. Deletions in loops 7, 8, 9, and 11 strongly decreased cobalamin binding and transport, whereas deletions in loops 8, 9, and 10 affected binding and entry of phage BF23. None of the loops were essential for the action of colicin E1 or E3, which is consistent with the crystallographic observation that the colicin E3 receptor-binding domain can contact almost all of the loops. A deletion in loop 9 or 11 eliminated the ability of cobalamin to inhibit the action of colicin E1. These phenotypes show that there are multiple independent binding elements and point out similarities and differences in binding properties among the TonB-dependent transporters." @default.
• W2015747109 created "2016-06-24" @default.
• W2015747109 creator A5036398068 @default.
• W2015747109 creator A5065760760 @default.
• W2015747109 date "2005-03-01" @default.
• W2015747109 modified "2023-09-26" @default.
• W2015747109 title "Multiple Extracellular Loops Contribute to Substrate Binding and Transport by the Escherichia coli Cobalamin Transporter BtuB" @default.
• W2015747109 cites W1495533261 @default.
• W2015747109 cites W1508513178 @default.
• W2015747109 cites W1515386059 @default.
• W2015747109 cites W1538296334 @default.
• W2015747109 cites W1572530872 @default.
• W2015747109 cites W1586400700 @default.
• W2015747109 cites W1601331206 @default.
• W2015747109 cites W163411833 @default.
• W2015747109 cites W1644961992 @default.
• W2015747109 cites W1865324261 @default.
• W2015747109 cites W1899247468 @default.
• W2015747109 cites W1981765089 @default.
• W2015747109 cites W1987641460 @default.
• W2015747109 cites W1989329079 @default.
• W2015747109 cites W2006580038 @default.
• W2015747109 cites W2022479853 @default.
• W2015747109 cites W2031546705 @default.
• W2015747109 cites W2039647109 @default.
• W2015747109 cites W2060786140 @default.
• W2015747109 cites W2072871401 @default.
• W2015747109 cites W2076272075 @default.
• W2015747109 cites W2084608838 @default.
• W2015747109 cites W2090880221 @default.
• W2015747109 cites W2108623931 @default.
• W2015747109 cites W2112453200 @default.
• W2015747109 cites W2115511385 @default.
• W2015747109 cites W2120061656 @default.
• W2015747109 cites W2125957234 @default.
• W2015747109 cites W2126776054 @default.
• W2015747109 cites W2132901866 @default.
• W2015747109 cites W2143413132 @default.
• W2015747109 cites W2151319524 @default.
• W2015747109 cites W2152967503 @default.
• W2015747109 cites W2158282653 @default.
• W2015747109 cites W2161819629 @default.
• W2015747109 cites W2169806444 @default.
• W2015747109 cites W2239384431 @default.
• W2015747109 doi "https://doi.org/10.1128/jb.187.5.1732-1739.2005" @default.
• W2015747109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1064007" @default.
• W2015747109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15716445" @default.
• W2015747109 hasPublicationYear "2005" @default.
• W2015747109 type Work @default.
• W2015747109 sameAs 2015747109 @default.
• W2015747109 citedByCount "18" @default.
• W2015747109 countsByYear W20157471092013 @default.
• W2015747109 countsByYear W20157471092019 @default.
• W2015747109 countsByYear W20157471092020 @default.
• W2015747109 crossrefType "journal-article" @default.
• W2015747109 hasAuthorship W2015747109A5036398068 @default.
• W2015747109 hasAuthorship W2015747109A5065760760 @default.
• W2015747109 hasBestOaLocation W20157471092 @default.
• W2015747109 hasConcept C104317684 @default.
• W2015747109 hasConcept C107824862 @default.
• W2015747109 hasConcept C115335371 @default.
• W2015747109 hasConcept C118892022 @default.
• W2015747109 hasConcept C12554922 @default.
• W2015747109 hasConcept C146587185 @default.
• W2015747109 hasConcept C149011108 @default.
• W2015747109 hasConcept C168707992 @default.
• W2015747109 hasConcept C170493617 @default.
• W2015747109 hasConcept C201663137 @default.
• W2015747109 hasConcept C24530287 @default.
• W2015747109 hasConcept C2779750884 @default.
• W2015747109 hasConcept C2779873506 @default.
• W2015747109 hasConcept C2780676250 @default.
• W2015747109 hasConcept C28406088 @default.
• W2015747109 hasConcept C41625074 @default.
• W2015747109 hasConcept C44312359 @default.
• W2015747109 hasConcept C51639874 @default.
• W2015747109 hasConcept C547475151 @default.
• W2015747109 hasConcept C55493867 @default.
• W2015747109 hasConcept C86803240 @default.
• W2015747109 hasConceptScore W2015747109C104317684 @default.
• W2015747109 hasConceptScore W2015747109C107824862 @default.
• W2015747109 hasConceptScore W2015747109C115335371 @default.
• W2015747109 hasConceptScore W2015747109C118892022 @default.
• W2015747109 hasConceptScore W2015747109C12554922 @default.
• W2015747109 hasConceptScore W2015747109C146587185 @default.
• W2015747109 hasConceptScore W2015747109C149011108 @default.
• W2015747109 hasConceptScore W2015747109C168707992 @default.
• W2015747109 hasConceptScore W2015747109C170493617 @default.
• W2015747109 hasConceptScore W2015747109C201663137 @default.
• W2015747109 hasConceptScore W2015747109C24530287 @default.
• W2015747109 hasConceptScore W2015747109C2779750884 @default.
• W2015747109 hasConceptScore W2015747109C2779873506 @default.
• W2015747109 hasConceptScore W2015747109C2780676250 @default.
• W2015747109 hasConceptScore W2015747109C28406088 @default.
• W2015747109 hasConceptScore W2015747109C41625074 @default.
• W2015747109 hasConceptScore W2015747109C44312359 @default.
• W2015747109 hasConceptScore W2015747109C51639874 @default.
• W2015747109 hasConceptScore W2015747109C547475151 @default.

• next