FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015753314> ?p ?o ?g. }

• W2015753314 endingPage "264" @default.
• W2015753314 startingPage "245" @default.
• W2015753314 abstract "Na+/H+ antiports or exchange reactions have been found widely, if not ubiquitously, in prokaryotic and eukaryotic membranes. In any given experimental system, the multiplicity of ion conductance pathways and the absence of specific inhibitors complicate efforts to establish that the antiport observed actually results from the activity of a specific secondary porter which catalyzes coupled exchanged of the two ions. Nevertheless, a large body of evidence suggests that at least some prokaryotes possess a delta psi-dependent, mutable Na+/H+ antiporter which catalyzes Na+ extrusion in exchange for H+; in other bacterial species, the antiporter my function electroneutrally, at least at some external pH values. The bacterial Na+/H+ antiporter constitutes a critical limb of Na+ circulation, functioning to maintain a delta mu Na+ for use by Na+-coupled bioenergetic processes. The prokaryotic antiporter is also involved in pH homeostasis in the alkaline pH range. Studies of mutant strains that are deficient in Na+/H+ antiporter activity also indicate the existence of a relationship, e.g., a common subunit or regulatory factor, between the Na+/H+ antiporter and Na+/solute symporters in several bacterial species. In eukaryotes, an electroneutral, amiloride-sensitive Na+/H+ antiport has been found in a wide variety of cell and tissue types. Generally, the normal direction of the antiport appears to be that of Na+ uptake and H+ extrusion. The activity is thus implicated as part of a complex system for Na+ circulation, e.g., in transepithelial transport, and might have some role in acidification in the renal proximal tubule. In many experimental systems, the Na+/H+ antiport appears to influence intracellular pH. In addition to a role in general pH homeostasis, such Na+-dependent changes in intracellular pH could be part of the early events in a variety of differentiating and proliferative systems. Reconstitution and structural studies, as well as detailed analysis of gene loci and products which affect the antiport activity, are in their very early stages. These studies will be important in further clarification of the precise structural nature and role(s) of the Na+/H+ antiporters. In neither prokaryotes nor eukaryotes systems is there yet incontrovertible evidence that a specific protein carrier, that catalyzes Na+/H+ antiport, is actually responsible for any of the multitude of effects attributed to such antiporters. The Na+-H+ exchange might turn out to be side reactions of other porters or the additive effects of several conductance pathways; or, as appears most likely in at least some bacteria and in renal tissue, the antiporter may be a discrete, complex carr" @default.
• W2015753314 created "2016-06-24" @default.
• W2015753314 creator A5026902813 @default.
• W2015753314 date "1983-12-01" @default.
• W2015753314 modified "2023-09-25" @default.
• W2015753314 title "Na+/H+ antiporters" @default.
• W2015753314 cites W106595354 @default.
• W2015753314 cites W123553014 @default.
• W2015753314 cites W1246495107 @default.
• W2015753314 cites W127330815 @default.
• W2015753314 cites W139870775 @default.
• W2015753314 cites W1444271771 @default.
• W2015753314 cites W144514618 @default.
• W2015753314 cites W147014518 @default.
• W2015753314 cites W1484197352 @default.
• W2015753314 cites W1485594756 @default.
• W2015753314 cites W1489324754 @default.
• W2015753314 cites W1496184314 @default.
• W2015753314 cites W1496382024 @default.
• W2015753314 cites W1508315241 @default.
• W2015753314 cites W1510058062 @default.
• W2015753314 cites W1511891385 @default.
• W2015753314 cites W1513290991 @default.
• W2015753314 cites W1514974310 @default.
• W2015753314 cites W1524232922 @default.
• W2015753314 cites W1524791290 @default.
• W2015753314 cites W1533674371 @default.
• W2015753314 cites W1538137511 @default.
• W2015753314 cites W1539754569 @default.
• W2015753314 cites W1558208511 @default.
• W2015753314 cites W1561036161 @default.
• W2015753314 cites W1568912507 @default.
• W2015753314 cites W1570821412 @default.
• W2015753314 cites W1581663892 @default.
• W2015753314 cites W1584359630 @default.
• W2015753314 cites W1584363878 @default.
• W2015753314 cites W1585268399 @default.
• W2015753314 cites W1590271961 @default.
• W2015753314 cites W1594691483 @default.
• W2015753314 cites W159485169 @default.
• W2015753314 cites W1602344975 @default.
• W2015753314 cites W1607058339 @default.
• W2015753314 cites W1645602382 @default.
• W2015753314 cites W1648567303 @default.
• W2015753314 cites W1652920192 @default.
• W2015753314 cites W1717876213 @default.
• W2015753314 cites W173763223 @default.
• W2015753314 cites W1784665074 @default.
• W2015753314 cites W1788247856 @default.
• W2015753314 cites W1835526604 @default.
• W2015753314 cites W1913357042 @default.
• W2015753314 cites W1947020094 @default.
• W2015753314 cites W1967379109 @default.
• W2015753314 cites W1968427114 @default.
• W2015753314 cites W1969374110 @default.
• W2015753314 cites W1970153582 @default.
• W2015753314 cites W1970178221 @default.
• W2015753314 cites W1973058160 @default.
• W2015753314 cites W1974338244 @default.
• W2015753314 cites W1976903338 @default.
• W2015753314 cites W1978399382 @default.
• W2015753314 cites W1979435339 @default.
• W2015753314 cites W1980051526 @default.
• W2015753314 cites W1981821726 @default.
• W2015753314 cites W1985143147 @default.
• W2015753314 cites W1985637387 @default.
• W2015753314 cites W1994229031 @default.
• W2015753314 cites W1994914337 @default.
• W2015753314 cites W1997654175 @default.
• W2015753314 cites W1999966891 @default.
• W2015753314 cites W2002049568 @default.
• W2015753314 cites W2002306733 @default.
• W2015753314 cites W2008090841 @default.
• W2015753314 cites W2010704664 @default.
• W2015753314 cites W2011747971 @default.
• W2015753314 cites W2011874967 @default.
• W2015753314 cites W2014297207 @default.
• W2015753314 cites W2014760103 @default.
• W2015753314 cites W2020107836 @default.
• W2015753314 cites W2021002736 @default.
• W2015753314 cites W2022459079 @default.
• W2015753314 cites W2026360538 @default.
• W2015753314 cites W2027813302 @default.
• W2015753314 cites W2029613788 @default.
• W2015753314 cites W2030613068 @default.
• W2015753314 cites W2031211208 @default.
• W2015753314 cites W2033524561 @default.
• W2015753314 cites W2035272773 @default.
• W2015753314 cites W2035375296 @default.
• W2015753314 cites W2035576108 @default.
• W2015753314 cites W2037617357 @default.
• W2015753314 cites W2038042676 @default.
• W2015753314 cites W2041363577 @default.
• W2015753314 cites W2042375106 @default.
• W2015753314 cites W2045152842 @default.
• W2015753314 cites W2046239497 @default.
• W2015753314 cites W2046555944 @default.
• W2015753314 cites W204962651 @default.

• next