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- W2015756875 abstract "Tenascin-X (TNX) is a large glycoprotein that appears in extracellular matrices. Previously, we demonstrated that TNX binds to vascular endothelial growth factors A and B (VEGF-A and -B) and that VEGF-B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR-1 receptor. In this study, we investigated the effect of TNX with VEGF-A on the cell proliferation in embryonic mouse heart explants from either wild-type (TNX+/+) or TNX-deficient (TNX−/−) mice. The addition of VEGF-A to the explants from TNX+/+ mice increased cell proliferation by 1.5 fold compared with that in TNX−/− mice, indicating that TNX with VEGF family member plays an important role in the control of endothelial cell proliferation in vivo." @default.
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- W2015756875 date "2001-01-01" @default.
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- W2015756875 title "Effect of Tenascin-X Together with Vascular Endothelial Growth Factor A on Cell Proliferation in Cultured Embryonic Hearts." @default.
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- W2015756875 doi "https://doi.org/10.1248/bpb.24.1320" @default.
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