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- W2015758049 abstract "Previous studies of the effects of chlorpromazine on eating and drinking gave conflicting results: The experiments described here show that chlorpromazine can have a biphasic time-course of action in rats, and that if this is taken into account, some of the apparently discrepant findings can be reconciled. For about 2 hr after administration, all the doses tested reduced food intake, but after that, the same doses stimulated eating. The long-term increases in food-intake seem consistent with most of the clinical literature. Rats given limited amounts of food to eat each day showed less clear stimulant responses than those allowed to eat for limited periods of time each day. Furthermore, records of spontaneous activity suggested that some form of generalized depression of behaviour might partly mask underlying stimulant effects on eating. Complex changes in hunger and thirst may therefore occur for several hours after chlorpromazine is given and these may be particularly important when food and water are used as rewards in experiments involving learning." @default.
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- W2015758049 title "Eating, drinking and spontaneous activity in rats after the administration of chlorpromazine" @default.
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- W2015758049 doi "https://doi.org/10.1016/0028-3908(70)90013-4" @default.
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