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• W2015761261 abstract "The mechanisms that subdivide the endoderm into the discrete primordia that give rise to organs such as the pancreas and liver are not well understood. However, it is known that retinoic acid (RA) signaling is critical for regionalization of the vertebrate embryo: when RA signaling is either prevented or augmented, anteroposterior (AP) patterning of the CNS and mesoderm is altered and major developmental defects occur [1Durston A.J. van der Wees J. Pijnappel W.W. Godsave S.F. Retinoids and related signals in early development of the vertebrate central nervous system.Curr. Top. Dev. Biol. 1998; 40: 111-175Crossref PubMed Google Scholar, 2Blumberg B. Bolado J.J. Moreno T.A. Kintner C. Evans R.M. Papalopulu N. An essential role for retinoid signaling in anteroposterior neural patterning.Development. 1997; 124: 373-379PubMed Google Scholar, 3Kessel M. Gruss P. Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid.Cell. 1991; 67: 89-104Abstract Full Text PDF PubMed Scopus (833) Google Scholar, 4Begemann G. Schilling T.F. Rauch G.J. Geisler R. Ingham P.W. The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain.Development. 2001; 128: 3081-3094Crossref PubMed Google Scholar, 5Dupé V. Ghyselinck N.B. Wendling O. Chambon P. Mark M. Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse.Development. 1999; 126: 5051-5059PubMed Google Scholar, 6Niederreither K. Subbarayan V. Dollé P. Chambon P. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development.Nat. Genet. 1999; 21: 444-448Crossref PubMed Scopus (855) Google Scholar, 7Wendling O. Dennefeld C. Chambon P. Mark M. Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches.Development. 2000; 127: 1553-1562PubMed Google Scholar, 8Wendling O. Ghyselinck N.B. Chambon P. Mark M. Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning.Development. 2001; 128: 2031-2038PubMed Google Scholar]. We have investigated the role of RA signaling in regionalization of the zebrafish endoderm. Using a mutant that prevents RA synthesis [4Begemann G. Schilling T.F. Rauch G.J. Geisler R. Ingham P.W. The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain.Development. 2001; 128: 3081-3094Crossref PubMed Google Scholar] and an antagonist of the RA receptors [7Wendling O. Dennefeld C. Chambon P. Mark M. Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches.Development. 2000; 127: 1553-1562PubMed Google Scholar, 8Wendling O. Ghyselinck N.B. Chambon P. Mark M. Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning.Development. 2001; 128: 2031-2038PubMed Google Scholar, 9Dupé V. Lumsden A. Hindbrain patterning involves graded responses to retinoic acid signaling.Development. 2001; 128: 2199-2208PubMed Google Scholar], we show that specification of both the pancreas and liver requires RA signaling. By contrast, RA signaling is not required for the formation of the endodermal germ layer or for differentiation of other endodermal organs. Timed antagonist and RA treatments show that the RA-dependent step in pancreatic specification occurs at the end of gastrulation, significantly earlier than the expression of known markers of pancreatic progenitors. In addition to being required for pancreatic specification, RA has the capacity to transfate anterior endoderm to a pancreatic fate." @default.
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• W2015761261 date "2002-07-01" @default.
• W2015761261 modified "2023-10-15" @default.
• W2015761261 title "Retinoic Acid Signaling Is Required for a Critical Early Step in Zebrafish Pancreatic Development" @default.
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• W2015761261 doi "https://doi.org/10.1016/s0960-9822(02)00929-6" @default.
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