Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015762721> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2015762721 endingPage "121" @default.
- W2015762721 startingPage "115" @default.
- W2015762721 abstract "We partially purified the glycoproteins prokallikrein and kallikrein from rat plasma. The purification of rat plasma kallikrein may result in two forms: an intact form (alpha, M(r) 84-87 kDa) and a partially degraded form (beta, M(r) 46-51 kDa). The alpha-form is composed of a heavy chain (M(r) 50 kDa) and a light chain (M(r) 34-37 kDa) linked by a disulfide bond. The catalytic site is found on the light chain. The beta-form has a partially degraded heavy chain (M(r) 28 kDa). Using a preparation of exsanguinated and perfused rat liver, we verified that rat plasma prokallikrein is not activated by the liver and that neither the proenzyme nor the light chain is removed by the organ. Both forms (alpha and beta) of the active enzyme are similarly removed from the perfusate. We also observed that the clearance of plasma kallikrein is temperature-dependent, and not affected by substances that inhibit binding to galactosyl-, mannosyl-, fucosyl- or phosphomannosyl-specific lectins, but inhibited by beta-galactosides. We suggest that: (a) the binding site to hepatocytes is latent on prokallikrein and is located on its heavy chain, more specifically on the 28-kDa fragment still present in the beta form of the active enzyme and (b) plasma kallikrein is recognized by an S-type lectin." @default.
- W2015762721 created "2016-06-24" @default.
- W2015762721 creator A5030216930 @default.
- W2015762721 creator A5061943066 @default.
- W2015762721 date "1992-01-01" @default.
- W2015762721 modified "2023-09-29" @default.
- W2015762721 title "The recognition site for hepatic clearance of plasma kallikrein is on its heavy chain and is latent on prokallikrein" @default.
- W2015762721 cites W116229851 @default.
- W2015762721 cites W1490499402 @default.
- W2015762721 cites W1490688374 @default.
- W2015762721 cites W1500508767 @default.
- W2015762721 cites W1513000136 @default.
- W2015762721 cites W1573617710 @default.
- W2015762721 cites W1965293723 @default.
- W2015762721 cites W1976053121 @default.
- W2015762721 cites W1998336764 @default.
- W2015762721 cites W1999620788 @default.
- W2015762721 cites W2041069870 @default.
- W2015762721 cites W2066180317 @default.
- W2015762721 cites W2069728664 @default.
- W2015762721 cites W2091004364 @default.
- W2015762721 cites W2100837269 @default.
- W2015762721 cites W2333160546 @default.
- W2015762721 cites W2394534585 @default.
- W2015762721 cites W4230354809 @default.
- W2015762721 cites W4242208495 @default.
- W2015762721 doi "https://doi.org/10.1016/s0168-8278(05)80103-5" @default.
- W2015762721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1484145" @default.
- W2015762721 hasPublicationYear "1992" @default.
- W2015762721 type Work @default.
- W2015762721 sameAs 2015762721 @default.
- W2015762721 citedByCount "21" @default.
- W2015762721 countsByYear W20157627212012 @default.
- W2015762721 countsByYear W20157627212017 @default.
- W2015762721 countsByYear W20157627212018 @default.
- W2015762721 countsByYear W20157627212023 @default.
- W2015762721 crossrefType "journal-article" @default.
- W2015762721 hasAuthorship W2015762721A5030216930 @default.
- W2015762721 hasAuthorship W2015762721A5061943066 @default.
- W2015762721 hasConcept C108625454 @default.
- W2015762721 hasConcept C153911025 @default.
- W2015762721 hasConcept C159654299 @default.
- W2015762721 hasConcept C181199279 @default.
- W2015762721 hasConcept C185592680 @default.
- W2015762721 hasConcept C203014093 @default.
- W2015762721 hasConcept C36394416 @default.
- W2015762721 hasConcept C52853521 @default.
- W2015762721 hasConcept C55493867 @default.
- W2015762721 hasConcept C71240020 @default.
- W2015762721 hasConcept C86803240 @default.
- W2015762721 hasConceptScore W2015762721C108625454 @default.
- W2015762721 hasConceptScore W2015762721C153911025 @default.
- W2015762721 hasConceptScore W2015762721C159654299 @default.
- W2015762721 hasConceptScore W2015762721C181199279 @default.
- W2015762721 hasConceptScore W2015762721C185592680 @default.
- W2015762721 hasConceptScore W2015762721C203014093 @default.
- W2015762721 hasConceptScore W2015762721C36394416 @default.
- W2015762721 hasConceptScore W2015762721C52853521 @default.
- W2015762721 hasConceptScore W2015762721C55493867 @default.
- W2015762721 hasConceptScore W2015762721C71240020 @default.
- W2015762721 hasConceptScore W2015762721C86803240 @default.
- W2015762721 hasIssue "1-2" @default.
- W2015762721 hasLocation W20157627211 @default.
- W2015762721 hasLocation W20157627212 @default.
- W2015762721 hasOpenAccess W2015762721 @default.
- W2015762721 hasPrimaryLocation W20157627211 @default.
- W2015762721 hasRelatedWork W1495518825 @default.
- W2015762721 hasRelatedWork W1578965502 @default.
- W2015762721 hasRelatedWork W168461730 @default.
- W2015762721 hasRelatedWork W1850986032 @default.
- W2015762721 hasRelatedWork W2015762721 @default.
- W2015762721 hasRelatedWork W2080203695 @default.
- W2015762721 hasRelatedWork W2088095411 @default.
- W2015762721 hasRelatedWork W2093869678 @default.
- W2015762721 hasRelatedWork W2358788700 @default.
- W2015762721 hasRelatedWork W4242974861 @default.
- W2015762721 hasVolume "16" @default.
- W2015762721 isParatext "false" @default.
- W2015762721 isRetracted "false" @default.
- W2015762721 magId "2015762721" @default.
- W2015762721 workType "article" @default.