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• W2015769892 endingPage "390" @default.
• W2015769892 startingPage "371" @default.
• W2015769892 abstract "The quality and performance of a solid oral dosage form depends on the choice of the solid phase, the formulation design, and the manufacturing process. The potential for process-induced solid phase transformations must be evaluated during design and development of formulations and manufacturing processes. This article briefly reviews the basic principles of polymorphism, defines the classes of phase transformation and the underlying transformation mechanisms, and discusses respective kinetic factors. The potential phase transformations associated with common unit operations employed in manufacturing solid oral dosage forms are highlighted. Specific examples are given to illustrate the importance of solid phases, and process-induced phase transitions in formulation and process development." @default.
• W2015769892 created "2016-06-24" @default.
• W2015769892 creator A5008974022 @default.
• W2015769892 creator A5017289651 @default.
• W2015769892 creator A5019910492 @default.
• W2015769892 creator A5088684431 @default.
• W2015769892 date "2004-02-23" @default.
• W2015769892 modified "2023-10-13" @default.
• W2015769892 title "Phase transformation considerations during process development and manufacture of solid oral dosage forms" @default.
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• W2015769892 doi "https://doi.org/10.1016/j.addr.2003.10.009" @default.
• W2015769892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14962587" @default.
• W2015769892 hasPublicationYear "2004" @default.

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