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- W2015772521 abstract "The hamster cheek pouch is an excellent model for the experimental induction of oral tumor by chemical carcinogens. We have previously shown that the cellular oncogene c-erb B1 is overexpressed in the cheek pouch of the Syrian hamster when transformed by the carcinogenic chemical dimethyl-benzanthracene (DMBA). Here we report that this cellular oncogene is amplified in one such chemically-induced oral carcinoma (HCP-T12) and in a cell line (HCPC-1) established from a similarly derived tumor. Furthermore we present preliminary evidence that the gene amplification is most likely through an extrachromosomal pathway. These data together suggest that the amplification of the c-erb B1 oncogene might be responsible for its overexpression in these chemically-induced oral carcinomas." @default.
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- W2015772521 date "1987-01-01" @default.
- W2015772521 modified "2023-09-30" @default.
- W2015772521 title "Amplification of the <i>c-erb B1</i> oncogene in chemically-induced oral carcinomas" @default.
- W2015772521 doi "https://doi.org/10.1093/carcin/8.12.1963" @default.
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