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• W2015774890 abstract "The liver is a unique organ with the potential to regenerate from injury. Hepatic stem cells contribute to liver regeneration when surviving hepatocytes in injured liver are unable to proliferate. To investigate the mechanism of liver regeneration in vitro, we established hepatic stem cell lines named HY1, HY2 and HY3, derived from a healthy liver of adult rat. HY cells showed an expression pattern similar to oval cells, and efficiently induced hepatic differentiation following sequential treatment with type I collagen, transforming growth factor-beta1 (TGF-beta1), and hepatocyte growth factor (HGF) or oncostatin M (OSM). These results suggested that HY cells are liver stem cells representing an excellent tool for in vitro studies on liver regeneration." @default.
• W2015774890 created "2016-06-24" @default.
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• W2015774890 date "2008-10-25" @default.
• W2015774890 modified "2023-10-16" @default.
• W2015774890 title "Establishment and Characterization of Hepatic Stem-like Cell lines from Normal Adult Rat Liver" @default.
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• W2015774890 doi "https://doi.org/10.1093/jb/mvn146" @default.
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